Patents Assigned to Vipergen ApS
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Patent number: 11634835Abstract: Provided is a method for screening an in vitro display library for binding within a cell of a small-molecule chemical compound binding entity of the library to a protein or RNA target of interest in order to identify at least one individual chemical compound binding entity of the library that is capable of binding within the cell to the protein or RNA target of interest.Type: GrantFiled: January 16, 2020Date of Patent: April 25, 2023Assignee: VIPERGEN APSInventors: Nils Jakob Vest Hansen, Jacob Andersen, Ole Kristensen, Allan Beck Christensen, Lars Kolster Petersen
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Publication number: 20220090051Abstract: Provided is a method for screening an in vitro display library for binding within a cell of a small-molecule chemical compound binding entity of the library to a protein or RNA target of interest in order to identify at least one individual chemical compound binding entity of the library that is capable of binding within the cell to the protein or RNA target of interest.Type: ApplicationFiled: January 16, 2020Publication date: March 24, 2022Applicant: VIPERGEN APSInventors: Nils Jakob, Vest HANSEN, Jacob ANDERSEN, Ole KRISTENSEN, Allan Beck CHRISTENSEN, Lars Kolster PETERSEN
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Patent number: 10513700Abstract: A method for making an enriched library comprising specific nucleic acid sequence information allowing to identifying at least one binding entity that binds to at least one target wherein the specific binding entity has been present in an in vitro display library.Type: GrantFiled: November 30, 2016Date of Patent: December 24, 2019Assignee: Vipergen ApSInventors: Nils Jakob Vest Hansen, Allan Beck Christensen, Leif Kongskov Larsen, Frank Abildgaard Slok, Lars Kolster Petersen, Judith Rasmussen-Dietvorst, Peter Blakskjaer, Tara Heitner Hansen, Johan Holmkvist
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Publication number: 20170233726Abstract: A method for making an enriched library comprising specific nucleic acid sequence information allowing to identifying at least one binding entity that binds to at least one target wherein the specific binding entity has been present in an in vitro display library.Type: ApplicationFiled: November 30, 2016Publication date: August 17, 2017Applicant: Vipergen ApSInventors: Nils Jakob Vest Hansen, Allan Beck Christensen, Leif Kongskov Larsen, Frank Abildgaard Slok, Lars Kolster Petersen, Judith Rasmussen-Dietvorst, Peter Blakskjaer, Tara Heitner Hansen, Johan Holmkvist
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Patent number: 9006150Abstract: Disclosed is a composition comprising the nucleic acid and a chemical compound, said composition forming a star structure defining 3 or more stems extending from a reaction center. The stems are formed by a nucleic acid duplex and the chemical compound has been formed in the reaction center as the reaction product of 3 or more chemical groups. The advantage of the composition is that a close proximity is provided between the chemical groups in the reaction center, thereby promoting a reaction. The invention also relates to a method for preparation of the composition. The advantage of the method is that it does not require the pre-synthesis of a large number of templates and that it is not dependent upon codon/anti-codon recognition for an encoded molecule to be formed.Type: GrantFiled: May 17, 2012Date of Patent: April 14, 2015Assignee: Vipergen ApSInventors: Nils Jokob Vest Hansen, Peter Blakskjaer, Margit Haahr Hansen, Lars Kolster Petersen, Tara Renee Heitner
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Publication number: 20130005581Abstract: Disclosed is a composition comprising the nucleic acid and a chemical compound, said composition forming a star structure defining 3 or more stems extending from a reaction center. The stems are formed by a nucleic acid duplex and the chemical compound has been formed in the reaction center as the reaction product of 3 or more chemical groups. The advantage of the composition is that a close proximity is provided between the chemical groups in the reaction center, thereby promoting a reaction. The invention also relates to a method for preparation of the composition. The advantage of the method is that it does not require the pre-synthesis of a large number of templates and that it is not dependent upon codon/anti-codon recognition for an encoded molecule to be formed.Type: ApplicationFiled: May 17, 2012Publication date: January 3, 2013Applicant: VIPERGEN APSInventors: Nils Jokob Vest Hansen, Peter Blakskjaer, Margit Haahr Hansen, Lars Kolster Petersen, Tara Renee Heitner
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Patent number: 8202823Abstract: Disclosed is a composition comprising a nucleic acid and a chemical compound, said composition forming a star structure defining 3 or more stems extending from a reaction center. The stems are formed by a nucleic acid duplex and the chemical compound has been formed in the reaction center as the reaction product of 3 or more chemical groups. The advantage of the composition is that a close proximity is provided between the chemical groups in the reaction center, thereby promoting a reaction. The invention also relates to a method for preparation of the composition. The advantage of the method is that it does not require the pre-synthesis of a large number of templates and that it is not dependent upon codon/anti-codon recognition for an encoded molecule to be formed.Type: GrantFiled: November 8, 2005Date of Patent: June 19, 2012Assignee: Vipergen ApSInventors: Nils Jakob Vest Hansen, Peter Blakskjaer, Margit Haahr Hansen, Lars Kolster Petersen, Tara Renee Heitner
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Publication number: 20090239768Abstract: The present invention provides compositions, compounds and methods for in vitro DNA display technology, allowing display of a variety of molecules, in particular molecules obtained by water incompatible mechanisms. Advantages of such methods are that combinatorial libraries can be constructed comprising molecules which are obtained through water incompatible reactions.Type: ApplicationFiled: May 3, 2007Publication date: September 24, 2009Applicant: VIPERGEN ApSInventors: Nils Jakob Vest Hansen, Peter Blakskjaer, Lars Kolster Petersen