Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton’s tyrosine kinase and which exhibit desirable characteristics for the same.
Type:
Application
Filed:
August 8, 2022
Publication date:
June 8, 2023
Applicants:
Viracta Therapeutics, Inc., Biogen MA Inc., Biogen MA Inc.
Inventors:
Brian T. HOPKINS, Timothy R. CHAN, Tracy J. JENKINS, Patrick CONLON, Xiongwei CAI, Michael HUMORA, Xianglin SHI, Ross A. MILLER, Andrew THOMPSON
Abstract: Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The methods can comprise administering to a subject a viral inducing agent with an antiviral agent, and optionally an additional agent. The viral inducing agent can be a HDAC inhibitor administered orally.
Type:
Application
Filed:
December 8, 2021
Publication date:
August 11, 2022
Applicants:
VIRACTA THERAPEUTICS, INC., TRUSTEES OF BOSTON UNIVERSITY
Abstract: Described herein are certain dosing schedules and amounts that effectively prevent and manage side effects associated with histone deacetylase inhibitor (HDACi) treatment. Optionally, these schedules and dosing regimens include treatment with an antiviral agent.
Type:
Grant
Filed:
July 8, 2020
Date of Patent:
March 23, 2021
Assignee:
VIRACTA THERAPEUTICS INC.
Inventors:
Robert McRae, Gail L. Brown, Xiaohu Deng, David Slack, Marshelle Smith Warren, Richard Trauger
Abstract: Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The methods can comprise administering to a subject a viral inducing agent with an antiviral agent, and optionally an additional agent. The viral inducing agent can be a HDAC inhibitor administered orally.
Type:
Grant
Filed:
April 23, 2018
Date of Patent:
December 8, 2020
Assignees:
TRUSTEES OF BOSTON UNIVERSITY, VIRACTA THERAPEUTICS, INC.
Abstract: Provided are methods and compositions for the treatment of cancer. The methods comprise administering to a subject an HDAC inhibitor and an immunotherapeutic. In certain instances the immunotherapeutic is a chimeric antigen receptor T cell, an antibody or polypeptide that binds a checkpoint inhibitor, or a vaccine.
Abstract: Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The methods can comprise administering to a subject a viral inducing agent with an antiviral agent, and optionally an additional agent. The viral inducing agent can be a HDAC inhibitor administered orally.
Type:
Application
Filed:
April 23, 2018
Publication date:
March 28, 2019
Applicants:
VIRACTA THERAPEUTICS, INC., TRUSTEES OF BOSTON UNIVERSITY