Patents Assigned to Viralytics Limited
  • Method of Treating a Malignancy in a Subject and a Pharmaceutical Composition for Use in Same
    Publication number: 20150037287
    Abstract: There is a disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognising at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Coxsackie A-group viruses have been found to be particularly suitable. The cell adhesion molecule is desirably a member of the immunoglobulin (Ig) superfamily. Typically, the complement regulatory protein will be DAF.
    Type: Application
    Filed: March 31, 2014
    Publication date: February 5, 2015
    Applicant: Viralytics Limited
    Inventor: Darren R. Shafren
  • Methods for treating malignancies using coxsackieviruses
    Patent number: 8722036
    Abstract: There is a disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognising at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Coxsackie A-group viruses have been found to be particularly suitable. The cell adhesion molecule is desirably a member of the immunoglobulin (Ig) superfamily. Typically, the complement regulatory protein will be DAF.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: May 13, 2014
    Assignee: Viralytics Limited
    Inventor: Darren R. Shafren
  • Methods and compositions for treatment of hematologic cancers
    Patent number: 8236298
    Abstract: The present invention relates to oncolytic Picornaviruses and methods and compositions for treating subjects having hematologic cancers. These include methods and compositions for treatment of myeloma, using disclosed Picornavirus such as Coxsackievirus, in methods of direct or indirect administration to subjects and ex vivo purging of malignant cells within auto grafts prior to transplantation.
    Type: Grant
    Filed: August 22, 2005
    Date of Patent: August 7, 2012
    Assignee: Viralytics Limited
    Inventors: Gough Geoffrey Au, Darren Raymond Shafren
  • Modified oncolytic viruses
    Patent number: 8114416
    Abstract: An isolated selected Picornavirus capable of lytically infecting or killing a cell substantially in the absence of intercellular adhesion molecule-1 (ICAM-1).
    Type: Grant
    Filed: January 17, 2005
    Date of Patent: February 14, 2012
    Assignee: Viralytics Limited
    Inventors: Eva Susanne Johansson, Darren Raymond Shafren
  • Method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis
    Patent number: 7485292
    Abstract: There are provided methods for treatment of abnormal cells such as cancer cells in a mammal. The methods involve treating the mammal with virus selected from echoviruses and modified forms and combination thereof, which recognize ?2?1 for infectivity of the cells. There are also provided methods for screening viruses for use in a method of the invention as well as pharmaceutical compositions for use in the methods.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: February 3, 2009
    Assignee: Viralytics Limited
    Inventor: Darren R. Shafren
  • Method and Composition for Treatment of Neoplasms
    Publication number: 20080160031
    Abstract: The invention relates to methods of treating a neoplasm in an animal, in particular treating a neoplasm in a human, through the use of isolated nucleic acid sequence, including synthetic viral RNA and complementary DNA, derived from one or more Picornaviruses. The invention also relates to compositions of isolated nucleic acids derived from one or more Picornaviruses, and to the use of isolated nucleic acids derived from one or more Picornaviruses for the manufacture of a medicament for the treatment of neoplasms in a mammal.
    Type: Application
    Filed: January 17, 2006
    Publication date: July 3, 2008
    Applicant: Viralytics Limited
    Inventor: Darren Raymond Shafren
  • Methods for treating malignancies expressing ICAM-1 using coxsackie a group viruses
    Patent number: 7361354
    Abstract: There is disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognizing at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the Picornaviridae family. Coxsackie A-group viruses have been found to be particularly suitable. The cell adhesion molecule is desirably a member of the immunoglobulin (Ig) superfamily. Typically, the complement regulatory protein will be DAF.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: April 22, 2008
    Assignee: Viralytics Limited
    Inventor: Darren R. Shafren