Patents Assigned to Virginia Commonwealth University Medical College of Virginia
  • Method for the treatment of chronic pain
    Patent number: 5352683
    Abstract: Chronic pain is alleviated in a mammal suffering therefrom by administering to the mammal a chronic pain alleviating amount of a nontoxic N-methyl-D-aspartate receptor antagonist such as dextromethorphan, dextrorphan, ketamine or pharmaceutically acceptable salt thereof, alone or in combination with a local anesthetic and optionally in sustained release dosage form.
    Type: Grant
    Filed: March 5, 1993
    Date of Patent: October 4, 1994
    Assignee: Virginia Commonwealth University Medical College of Virginia
    Inventors: David J. Mayer, Donald D. Price, Jianren Mao, John W. Lyle
  • Inhibiting the development of tolerance to and/or dependence on an addictive substance
    Patent number: RE39300
    Abstract: Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA-receptor activation, e.g., a ganglioside such as GM1 or GT1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e.g., narcotic analgesics such as morphine, codeine, etc.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: September 19, 2006
    Assignee: Virginia Commonwealth University Medical College of Virginia
    Inventors: David J. Mayer, Jianren Mao