Abstract: This document relates to compounds as well as methods and materials involved in modulating neurotransmitter reuptake. For example, compounds, methods for synthesizing compounds, and methods for inhibiting neurotransmitter reuptake are provided. Specifically gamma-amino alcohol derivatives that inhibit the reuptake of neurotransmitters such as dopamine, serotonin, epinephrine or norepinephrine are provided as therapeutic agents for the treatment of depression or anxiety in a mammalian subject.

Abstract: The present invention concerns a system and method for fabricating a three-dimensional object. A build platform is provided that defines a build area and includes a print bed within the build area. Also provided is an extruder that extrudes build material. An ejector having at least one arm that has at least two opposing ends is used to remove the printed object. The first end of the ejector is adapted to travel in a vertical direction and the second end is adapted to travel in a horizontal direction. A scraper portion extends horizontally, parallel to the print bed from a retracted position to an extended position when the first end travels in a vertical direction towards the print bed.

Abstract: Aspects of the disclosure provide a system having a power circuit. The power circuit includes a first switch circuit having at least a first transistor and a second switch circuit having at least a second transistor. Further, the power circuit includes first interconnections configured to couple the first switch circuit to driving nodes, a source node and a drain node of the power circuit, and second interconnection configured to couple the second switch circuit in parallel to the first switch circuit to the driving nodes, the source node and the drain node of the power circuit. A polarity of unbalance in the first interconnections and the second interconnections dominates a polarity of current unbalance in the first switch circuit and the second switch circuit.

Abstract: The present invention provides a method and system for a processing multicarrier signal to create a spectral correlation across multiple antennas. The system includes at least one transmitter adapted to create a plurality of symbols, each symbol representing one or more bits from a plurality of bitstreams. The transmitter creates a plurality of repetition patterns, each pattern containing a copy of the symbols and each repetition pattern comprising a combination of symbols that varies in time, frequency and space. The repetition patterns are transmitted over and received by one or more separate antennas where a receiver demodulates the repetition patterns and linearly combines each repeated symbols across time, frequency and space to estimate said transmitted symbol.

Abstract: A system and method for genotyping tandem repeats in sequencing data. The invention uses Bayesian model selection guided by an empirically-derived error model that incorporates properties of sequence reads and reference sequences to which they map.

Abstract: Switches of a switching circuit used to control operation of an electric motor such as in an electrically powered vehicle connect respective windings of the electric motor as a single phase inductor during battery charging. The inductor can then store inherent low frequency, second order ripple power and return that power to a load presented by a battery during battery charging to deliver substantially constant current. Storage of ripple power in the inductor allows the capacitance value, size, weight and cost of a filter capacitor of a power factor correction circuit providing input power to a battery charger to be reduced by an order of magnitude or more. Direction of current flow through the inductor is periodically reversed to avoid magnetizing the motor.

Abstract: Aspects of interface converter common mode (CM) voltage control are described. In one embodiment, a bi-directional alternating current (AC) to direct current (DC) interface converter system includes an AC-DC converter between an AC power system and an interface link and a DC-DC converter between a DC power system and the interface link. The AC-DC converter can include a bridge converter having power switches, such as field-insulated gate bipolar transistors (IGBTs) or another power semiconductor device. The system also includes a control loop that generates control signals for switching the power switches of the AC-DC converter, and a CM control loop that injects a CM control signal into the control loop. By injecting the CM control signal into the control loop, low-frequency ripple and asymmetry between positive and negative output voltages of the DC power system can be reduced.

Abstract: A method for manufacturing a three dimensional object includes steps of: providing a digital description of the object as a set of voxels; sequentially creating an actual set of voxels corresponding to the digital set of voxels. At least one voxel comprises a polymer derived from: polyol and an ionic monomer. The calculated charge density of the resulting polymer is 0.01 to 0.7 mEq/g.

Abstract: The present invention provides four purified preparation containing a polynucleic acid molecule encoding porcine Torque teno virus (PTTV) genotypes or subtypes PTTV1a-VA, PTTV1b-VA, PTTV2b-VA, and PTTV2c-VA. The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of the same. The present invention further provides live, attenuated, vector-expressed and purified recombinant capsid subunit or killed viral vaccines for protection against PTTV infection. The present invention additionally provides subunit vaccines comprising PTTV specific gene products, especially ORF1 capsid gene product for protection against PTTV infection. Further, the present invention provides methods for diagnosing PTTV infection via polymerase chain reaction (PCR) using specific primer for PTTV1, PTTV2, and individual PTTV1 genotypes.

Abstract: The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.

Abstract: A computer system for distinguishing user-initiated network traffic from malware-initiated network traffic comprising at least one central processing unit (CPU) and a memory communicatively coupled to the CPU. The memory includes a program code executable by the CPU to monitor individual network events to determine for an individual network event whether the event has a legitimate root-trigger. Malware-initiated traffic is identified as an individual network event that does not have a legitimate root-trigger.

Abstract: The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.

Abstract: A system and method that comprises an X-ray source configured to emit an X-ray beam; an object positioned to receive the X-ray beam; a detector configured to receive an attenuated beam of the X-rays through the object for measuring projection data from various orientations that can be used to generate spectral images in terms of energy-dependent linear attenuation coefficients, and a detector, as described above, comprising one or more energy-integrating detector elements and one or more photon counting detector elements in one or more detectors array or separate detector arrays. The photon counting detector elements may also use dynamic thresholds to define energy windows.

Abstract: A power circuit includes a power source for providing electrical power and two driving transistors being disposed in parallel and receiving electrical power from the power source. Each of the two driving transistors includes a gate terminal, a source connection, and a kelvin source connection. The power circuit also includes a control voltage source having a first terminal and a second terminal. The control voltage source provides a control signal to the two driving transistors for determining driving currents through the two driving transistors. The first terminal is connected to the gate terminals of the two driving transistors, and the second terminal is connected to the kelvin source connections of the two driving transistors. The kelvin source connections of the two driving transistors are inductively coupled.

Abstract: The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a non-pathogenic PCV1 virus genome. In a particular embodiment, the PCV2 capids gene is of subtype PCV2b, the predominant subtype circulating in pigs worldwide. The attenuated chimeric virus, designated PCV1-2b, effectively protects pigs from PCV2b challenges, and can be used as a live vaccine, as well as an inactivated (killed) vaccine, that provides protection and cross protection against PCV2b and PCV2a subtypes infection. The live attenuated vaccine of the present invention is also effective protecting pigs from porcine circovirus-associated disease (PCVAD).

Abstract: A two-stage power converter architecture including an isolation transformer and rectification of the isolation transformer output by an LLC resonant circuit and methodology for operating the same feeds an output voltage back to a circuit for generating waveforms for controlling a totem pole circuit to provide output voltage regulation as well as rectification of AC input voltage. The circuit for controlling the totem pole circuit may also be responsive to the AC input power waveform to provide power factor correction (PFC), in which case, the feedback signal provides additional pulse width modulation of the PFC signals. Bus capacitor size may also be reduced by injecting harmonics of the AC input waveform into the feedback signal which also serves to substantially maintain efficiency of the (preferably LLC) resonant second stage.

Abstract: The present invention provides a radio architecture that contains a main radio path and a sensing path. The parameters of the main radio path are controlled by a cognitive engine. The main radio path is tuned to a desired frequency band. The sensing path is used to monitor the spectrum around the desired frequency band. To minimize effects of undesired non-linearity on sensing, sensing path may have a lower gain setting. The cognitive engine determines the optimal setting of the main RF front-end with respect to the current state of the spectrum.

Abstract: A voltage waveform similar to a waveform of a magnetizing current of an isolation transformer and immune to high frequency oscillatory resonant behavior is developed across a capacitor of a series resistor and capacitor connection connected in parallel with a synchronous rectifier. A simple logic circuit produces a waveform for controlling the synchronous rectifier which is not subject to significant turn on delay or early turn off caused by oscillatory resonances among parasitic inductances and capacitances. Improved timing accuracy of a synchronous converter provides improved power converter accuracy, particularly for flyback converters which are commonly used in converters for supplying power to offline electrical devices but are subject to oscillatory resonant behaviors that cannot be adequately damped at switching frequencies sufficiently high to support miniaturization of adapters.

Abstract: Procedures are described for enhancing target system execution integrity determined by power fingerprinting (PFP): by integrating PFP into the detection phase of comprehensive defense-in-depth security; by deploying a network of PFP enabled nodes executing untrusted devices with predefined inputs forcing a specific state sequence and specific software execution; by embedding module identification information into synchronization signaling; by combining signals from different board elements; by using malware signatures to enhance PFP performance; by automatic characterization and signature extraction; by providing secure signature updates; by protecting against side-channel attacks; performing real-time integrity assessment in embedded platform by monitoring their dynamic power consumption and comparing it against signatures from trusted code, including pre-characterizing power consumption of the platform by concentrating on trace sections carrying the most information about the internal execution status; by u

Abstract: The present invention provides a method for testing a helmet that uses a risk function that incorporates both linear and rotational acceleration to predict the helmet's ability to prevent a concussion. In certain embodiments, the testing matrix includes 3 impact energy levels and 4 impact locations, for a total of 12 testing conditions per helmet.