Patents Assigned to Virginia
  • Low power receiver and related circuits
    Patent number: 11929714
    Abstract: Low power radio frequency (RF) receivers and related circuits are described.
    Type: Grant
    Filed: January 16, 2020
    Date of Patent: March 12, 2024
    Assignee: University of Virginia Patent Foundation
    Inventors: Jesse Moody, Anjana Dissanayake, Benton H. Calhoun, Steven M. Bowers
  • HYALURONAN IS A DRIVER OF COVID-19 SEVERITY
    Publication number: 20240075055
    Abstract: Methods for treating coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, are described. The methods can be used to reduce the severity of outcomes related to COVID-19, such as hospitalization and ventilation. For example, the methods can involve treatment of a subject with a therapeutic agent that degrades hyaluronan and/or an agent that neutralizes a hyaluronan receptor, e.g., CD44, such as an anti-CD44 antibody.
    Type: Application
    Filed: December 22, 2021
    Publication date: March 7, 2024
    Applicants: University of Virginia Patent Foundation, The University of Manchester
    Inventors: William A. Petri, JR., Alexandra N. Donlan, Judith E. Allen, Tara Elaine Sutherland, Anthony John Day
  • Devices and methods for repairing damage to a tissue
    Patent number: 11918801
    Abstract: An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.
    Type: Grant
    Filed: November 5, 2021
    Date of Patent: March 5, 2024
    Assignees: BioCircuit Technologies, Inc., Virginia Commonwealth University
    Inventors: Jonathan Isaacs, Isaac Perry Clements, Andrew Willsie, James David Ross, Alex Weidenbach
  • Power Schottky barrier diodes with high breakdown voltage and low leakage current
    Patent number: 11923463
    Abstract: This disclosure provides a diode including a semiconductor region having at least one two-dimensional carrier channel of a first conductivity type. The diode also includes a plurality of sidewalls exposed in the semiconductor region defining at least one trench extending through the at least one two-dimensional carrier channel and a material of a second conductivity type, the second conductivity type being the other of the n-type and the p-type conductivity, disposed on the plurality of sidewalls and in contact with the at least one two-dimensional carrier channel. The diode also includes an anode material in contact with at least a portion of the semiconductor region and in contact with at least a portion of the material of the second conductivity type, and a cathode material in contact with the at least one two-dimensional carrier channel.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: March 5, 2024
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: Yuhao Zhang, Ming Xiao
  • Computational framework for modeling of physical process
    Patent number: 11914937
    Abstract: Techniques, systems, and devices are described for providing a computational frame for estimating high-dimensional stochastic behaviors. In one exemplary aspect, a method for performing numerical estimation includes receiving a set of measurements of a stochastic behavior. The set of correlated measurements follows a non-standard probability distribution and is non-linearly correlated. Also, a non-linear relationship exists between a set of system variables that describes the stochastic behavior and a corresponding set of measurements. The method includes determining, based on the set of measurements, a numerical model of the stochastic behavior. The numerical model comprises a feature space comprising non-correlated features corresponding to the stochastic behavior. The non-correlated features have a dimensionality of M and the set of measurements has a dimensionality of N, M being smaller than N.
    Type: Grant
    Filed: February 13, 2023
    Date of Patent: February 27, 2024
    Assignees: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC, VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
    Inventors: Xiao Chen, Can Huang, Liang Min, Charanraj Thimmisetty, Charles Tong, Yijun Xu, Lamine Mili
  • Bifuran polyesters
    Patent number: 11912819
    Abstract: Semicrystalline polyethylene-2,2?-bifuran-5,5?-dicarboxylate (PEBF) homopolyester or copolyester with up to 5 mole percent isophthalate or up to 2.7 mole percent terephthalate, based on the diacid component, or up to 2.5 mole percent 1,4-cyclohexanedimethanol (CHDM), based on the diol component, prepared by esterifying or transesterifying the diacid and the diol components with a catalyst including about 10 to about 50 ppm wt metal, and polycondensation, wherein the bifuran polyester has an intrinsic viscosity of at least 0.4 g/dL and a semicrystalline melting peak (Tm) with ?Hf equal to or greater than 5 J/g on the second heating ramp.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: February 27, 2024
    Assignees: ExxonMobil Chemical Patents, Inc., Virginia Tech Intellectual Properties, Inc.
    Inventors: Monica Lotz, Kapil Kandel, Michael Salciccioli, Stephen Cohn, Alan A. Galuska, Javier Guzman, S. Richard Turner, Hans Eliot Edling, Edward E. Paschke
  • Methods and systems for generating declarative statements given documents with questions and answers
    Patent number: 11914954
    Abstract: Described herein are systems and methods to enable generation of high-quality summaries of documents that have questions and answers. To help summarize such documents, parsing methods are disclosed that account for different document formats. Methods are disclosed to anonymize personal and identifying information present in the documents. An ontology is defined to categorize dialog acts for the questions and answers present. Classifiers are disclosed based on this ontology. Methods are also disclosed to transform a question-answer pair to a canonical form. Based on the dialog acts for the question and answer combination, transformation methods were developed that build upon each of traditional NLP, and deep learning, techniques.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: February 27, 2024
    Assignee: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
    Inventors: Edward A. Fox, Saurabh Chakravarty, Raja Venkata Satya Phanindra Chava, Maanav Mehrotra
  • SYSTEM AND METHOD FOR BODY MASS INDEX RELATION TO PATIENT DIFFERING PSYCHOLOGICAL STRESS EFFECT ON BLOOD GLUCOSE DYNAMICS IN PATIENTS WITH INSULIN DEPENDENT DIABETES
    Publication number: 20240058533
    Abstract: An insulin device configured to control insulin dispensing based on insulin sensitivity. The insulin device includes a processor configured to receive insulin dosing schedule information, psychological stress level data, and body mass index (BMI) data; a sensor configured to generate a blood glucose level measurement. The sensor is calibrated as a function of the psychological stress level data and the BMI data and the processor is configured to monitor and detect changes of the blood glucose level measurement that are determined to have occurred as a function of changes of the psychological stress level data, and identify a time when the BMI data counteracts a detected change in the blood glucose level measurement. The insulin device also includes an insulin dispensing valve controlled by the processor to change the insulin dosing schedule information in accordance with the counteracting BMI data.
    Type: Application
    Filed: October 26, 2023
    Publication date: February 22, 2024
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Stephen D. PATEK, Basak OZASLAN, Linda GONDER-FREDERICK
  • Serotonin transporter gene and treatment of opioid-related disorders
    Patent number: 11905562
    Abstract: The gene responsible for encoding SERT has a functional polymorphism at the 5?-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3? UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: February 20, 2024
    Assignee: University of Virginia Patent Foundation
    Inventor: Bankole A. Johnson
  • Occlusive implant compositions
    Patent number: 11904068
    Abstract: Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.
    Type: Grant
    Filed: February 17, 2022
    Date of Patent: February 20, 2024
    Assignee: University of Virginia Patent Foundation
    Inventors: John C. Herr, Alexander L. Klibanov, Kevin Simon Eisenfrats
  • Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
    Patent number: 11903690
    Abstract: Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: February 20, 2024
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventors: Rafael V. Davalos, Mohammad Bonakdar, Eduardo L. Latouche, Roop L. Mahajan, John L. Robertson, Christopher B. Arena, Michael B. Sano
  • Particles functionalized with imageable radioisotopes and methods of making and use thereof
    Patent number: 11904029
    Abstract: Some embodiments relate to imageable radioisotopic microspheres. In some embodiments, the imageable microspheres are radiolabeled with imageable radioisotopes. In some embodiments, the imageable radioisotope is directly coupled to a surface of a substrate of the microsphere. In some embodiments, the imageable microspheres can be used as surrogate particles to predict the distribution of therapeutic microspheres comprising radiotherapeutic isotopes.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: February 20, 2024
    Assignees: Boston Scientific Medical Device Limited, University of Virginia Patent Foundation
    Inventors: James Radford Stone, Kiel Douglas Neumann, Matthew Robert Dreher
  • Chimeric recombinant proteins and recombinant protein panels for the diagnosis of Lyme disease in animals and humans
    Patent number: 11899015
    Abstract: Chimeric recombinant proteins for the detection of infection by Borreliella and/or diagnosis of Lyme disease are provided. Methods and devices for conducting immunoassays with the chimeric recombinant proteins are also provided.
    Type: Grant
    Filed: October 24, 2022
    Date of Patent: February 13, 2024
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventor: Richard Marconi
  • Compositions and methods for preparing and using mitochondrial uncouplers
    Patent number: 11896591
    Abstract: This disclosure provides compounds of Formula I, II, and III and pharmaceutically acceptable salts thereof for use as mitochondrial uncouplers, where the variables, e.g. R1-R9, X1, X2, and Y1 are defined in the specification. The disclosure also provides pharmaceutical compositions comprising a compound or pharmaceutically acceptable salt of Formula I, II, or III, alone or in combination with another active compound. Compounds and compositions of Formula I, II, and III are useful for treating or preventing certain conditions such as obesity, type II diabetes, fatty liver disease, insulin resistance, Parkinson's disease, ischemia reperfusion injury, heart failure, non-alcoholic fatty liver disease (NALFD), and non-alcoholic steatohepatitis (NASH). Compounds of Formula I, II, and III are also useful for regulating glucose homeostatis and insulin action.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: February 13, 2024
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Kyle Hoehn, Webster L. Santos, Elizabeth S. Childress, Yumin Dai, Jacob Murray, Jose Santiago-Rivera
  • System, method and computer readable medium for dynamical tracking of the risk for hypoglycemia in type 1 and type 2 diabetes
    Patent number: 11901079
    Abstract: A system, method and non-transient computer readable medium for tracking hypoglycemia risk in patients with diabetes exercise. A system may include a digital processor configured to execute instructions to receive an input from each available data source of a plurality of intermittently available data sources; determine a plurality of probability signals for impending hypoglycemia, wherein each probability signal is based on one or more of the inputs from the available data sources or a lack of input from an unavailable data source; wherein a probability signal for each unavailable data source is assigned a value corresponding to a zone of uncertainty; and determine an aggregate risk of hypoglycemia based on the plurality of intermittently data sources by aggregating the plurality of probability signals.
    Type: Grant
    Filed: March 1, 2022
    Date of Patent: February 13, 2024
    Assignee: University of Virginia Patent Foundation
    Inventors: Marc D. Breton, Boris P. Kovatchev
  • High current DC-DC converter with integrated matrix transformer and multiphase current doubler rectifier
    Patent number: 11894778
    Abstract: Aspects of direct current (DC)-DC converters with an integrated matrix transformer and multiphase current doubler rectifiers are described. In some examples, a DC-DC converter can include a matrix transformer that has multiple magnetically integrated transformer components that are magnetically integrated using transformer components that share a top plate and a bottom plate. A multiphase current doubler rectifier can include multiple synchronous rectifiers corresponding to the plurality of transformer components of the matrix transformer.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: February 6, 2024
    Assignee: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
    Inventors: Xin Lou, Qiang Li, Fred C. Lee
  • Inhibitors of cancer invasion, attachment, and/or metastasis
    Patent number: 11891399
    Abstract: Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.
    Type: Grant
    Filed: January 14, 2021
    Date of Patent: February 6, 2024
    Assignees: VIRGINIA COMMONWEALTH UNIVERSITY, SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Paul B. Fisher, Maurizio Pellecchia, Swadesh K. Das, Timothy P. Kegelman, Bainan Wu, Surya K. De, Jun Wei, Mitchell E. Menezes, Luni Emdad
  • System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
    Patent number: 11890046
    Abstract: A medical system for ablating a tissue site with real-time monitoring during an electroporation treatment procedure. A pulse generator generates a pre-treatment (PT) test signal prior to the treatment procedure and intra-treatment (IT) test signals during the treatment procedure. A treatment control module determines impedance values from the PT test signal and IT test signals and determines a progress of electroporation and an end point of treatment in real-time based on the determined impedance values while the treatment progresses.
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: February 6, 2024
    Assignees: Virginia Tech Intellectual Properties, Inc., AngioDynamics, Inc.
    Inventors: Robert Neal, II, Rafael V. Davalos
  • Plectin-targeted liposomes/PARP inhibitor in the treatment of cancer
    Patent number: 11890352
    Abstract: The present invention provides compositions and methods to treat cancer.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: February 6, 2024
    Assignee: University of Virginia Patent Foundation
    Inventors: Kimberly A. Kelly, Siva Sai Krishna Dasa
  • ENZYMATIC BIOCIDE FOR REMOVAL OF FOODBORNE MICROBIAL CONTAMINATION
    Publication number: 20240034754
    Abstract: Provided are polypeptides that have at least about 95% but less than 100% sequence identity to SEQ ID NO: 2, optionally wherein the polypeptide has an amino acid sequence as set forth in SEQ ID NO: 4, with the proviso that the polypeptide does not have 100% sequence identity to SEQ ID NO: 2.
    Type: Application
    Filed: May 8, 2023
    Publication date: February 1, 2024
    Applicant: University of Virginia Patent Foundation
    Inventors: Bryan Berger, Holly Mayton