Abstract: Oxadiazolyl-phenoxyalkylisoxazoles and pharmaceutically acceptable salts thereof, compositions comprising oxadiazolyl-phenoxyalkylisoxazole compounds or pharmaceutically acceptable salts thereof and methods for using oxadiazolyl-phenoxyalkylisoxazole compounds or pharmaceutically acceptable salts thereof as anti-picornaviral agents are described herein. The methods include using pleconaril as a prodrug for conversion to anti-picornaviral compounds in vivo.

Abstract: The present invention provides pharmaceutical compositions useful in treating hepatitis C infection. The present invention also provides methods of treating hepatitis C infection by administering to a mammal the pharmaceutical compositions of the present invention.

Abstract: The invention is directed to a compound of the formula: wherein substitutions fat R1, R2, R3-R12, and Y are set forth in the specification; pharmaceutical compositions comprising said compound, methods of treating or preventing a Hepatitis C viral infection in a mammal comprising contacting the mammal with an effective amount of said compound or pharmaceutical compositions including said compound and methods of inhibiting replication of a Hepatitis C virus comprising contacting the HCV virus with an effective amount of said compound or pharmaceutical compositions including said compound.

Abstract: Substantially pure polymorphic forms of 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide are produced by recrystallization in an organic solvent.

Abstract: Novel hepatitis C virus (“HCV”) inhibitor combinations comprising an HCV protease inhibitor and HCV polymerase inhibitor, and optionally one or more biologically active agents, as well as uses of these combinations as HCV inhibitors and for treating hepatitis C and related disorders are disclosed.

Abstract: The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.

Abstract: The invention is directed to methods of treating, preventing, or inhibiting a Hepatitis C viral infection in a mammal comprising contacting the mammal with an effective amount of a compound of the formula: Wherein substitutions at R1, R2, R3—R12, and Y are set forth in the specification.

Abstract: The invention is directed to methods of treating, preventing, or inhibiting a Hepatitis C viral infection in a mammal comprising contacting the mammal with an effective amount of a compound of the formula: 1

Abstract: The invention is directed to a compound and a pharmaceutical composition of the formula: 1

Abstract: Triazinoindole derivatives are useful in the prophylaxis and treatment of pestivirus infections and diseases associated with pestivirus infections.

Abstract: Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.

Abstract: Methods are provided for the treatment and prophylaxis of viral infection and disease associated with such infection.

Abstract: Methods are provided for the treatment and prophylaxis of viral infection and disease associated with such infection.

Abstract: A compound produced by the process comprising the step of reacting a starting compound of the formula: with FeCl3 in the presence of acetic acid, wherein the reaction mixture is heated and the temperature of the reaction mixture is about 85° C.to about reflux temperature, R1 and R2 in the above formula being as defined in the present specification.

Abstract: Compounds of the formula: wherein R1 represents a lower alkyl (C1-C6) substituent which may be straight or branched; R2 represents an aryl substituent of the formula: and Q, V, W, X, Y and Z are as set forth in the accompanying specification, are useful in prophylaxis of influenza virus infection.

Abstract: Derivatives of piperidine are useful in prophylaxis and treatment of hepatitis C virus infections.

Abstract: Compounds of the formula: ##STR1## wherein R1 represents a lower alkyl (C1-C6) substituent which may be straight or branched; R2 represents an aryl substituent of the formula: ##STR2## and Q, V, W, X, Y and Z are as set forth in the accompanying specification, are useful in prophylaxis of influenza virus infection.

Abstract: Triazinoindole derivatives are useful in the prophylaxis and treatment of pestivirus infections and diseases associated with pestivirus infections.

Abstract: Derivatives of piperidine are useful in prophylaxis and treatment of hepatitis C virus infections.

Abstract: A compound of the formula: ##STR1## wherein R.sub.1 represents a lower alkyl (C.sub.1 --C.sub.6) substituent which may be straight or branched; R.sub.2 represents an aryl substituent of the formula: ##STR2## and Q, V, W, X, Y and Z are as set forth in the accompanying specification. These compounds are useful in prophylaxis and treatment of influenza virus infection.