Abstract: The present disclosure is directed to compositions comprising one or more components of a polypeptide, a reovirus-derived targeting protein, and a cleavable linker, and related methods and compositions for the generation of tolerance against the polypeptide. In some embodiments, the polypeptide is antigenic, such as comprising at least one epitope from a food allergen, an environmental allergen, an auto-antigen, and/or a biological therapeutic, and/or at least one epitope derived therefrom.
Type:
Application
Filed:
February 10, 2017
Publication date:
March 7, 2019
Applicant:
Virtici, LLC
Inventors:
Neil A. Fanger, Paul Hill, Stacy Martin
Abstract: The present disclosure is directed to compositions comprising one or more components of a polypeptide allergen combined with a reovirus-derived targeting protein, and related methods for the generation of tolerance against the polypeptide allergens.