Abstract: The invention relates to pharmaceutical compositions comprising a conjugate of a porphyrin (e.g., PpIX) and a recombinant protein. The pharmaceutical compositions of the invention may be used in photodynamic therapy. The invention also relates to methods of producing such pharmaceutical compositions and to methods of using such pharmaceutical compositions in the treatment of diseases, such as cancer.
Type:
Grant
Filed:
June 27, 2018
Date of Patent:
March 16, 2021
Assignee:
VISION GLOBAL HOLDINGS LIMITED
Inventors:
Sui Yi Kwok, Norman Fung Man Wai, Terence Shau Yin Wai, Shan Yu
Abstract: Provided herein are mertansine polypeptide conjugates useful in the treatment of cancer, pharmaceutical compositions comprising the same, and methods of use and preparation thereof. The methods provided herein are highly N-terminal selective and are capable of yielding N-terminal mertansine conjugated polypeptides with site selectivity of 99% or greater.
Type:
Grant
Filed:
May 14, 2020
Date of Patent:
February 9, 2021
Assignee:
Vision Global Holdings Limited
Inventors:
Sui-Yi Kwok, Norman Fung-Man Wai, Man-Kin Wong, Benjamin Chi-Yin Wai
Abstract: The invention relates to pharmaceutical compositions comprising a conjugate of a porphyrin (e.g., PpIX) and a recombinant protein. The pharmaceutical compositions of the invention may be used in photodynamic therapy. The invention also relates to methods of producing such pharmaceutical compositions and to methods of using such pharmaceutical compositions in the treatment of diseases, such as cancer.
Type:
Application
Filed:
June 27, 2018
Publication date:
February 21, 2019
Applicant:
VISION GLOBAL HOLDINGS LIMITED
Inventors:
Sui Yi KWOK, Norman Fung Man WAI, Terence Shau Yin WAI, Shan YU
© 2024 Justia
