Abstract: A system and method for performing multiple modes of electro-therapy with a portable electro-therapy device are disclosed. Preferably, the modes include an interferential mode, a pre-modulated interferential mode, a neuromuscular mode and a high volt pulse current mode. Additional protocols may be defined by combining or varying modes. The electro-therapy device uses a microprocessor to generate and control output signals. The microprocessor is contained within the housing of the electro-therapy device. The device includes a display and at least one keypad. The device also includes an electrode jack for attaching at least one pair of electrodes for outputting signals to a patient.