Abstract: A removable control knob/brake assembly for an endoscope having a handle and an insertion tube. The assembly is intended to be used with endoscopes which use protective bags or sheaths to isolate the insertion tube and the remainder of the handle from the internal environment of a patient. The control knob/brake assembly is not otherwise protected so, after being used, it must be removed for cleaning. A simple push button release mechanism is provided to easily remove the assembly from the handle. Retaining screws and a retaining clip are provided to prevent the control knob/brake assembly from coming apart when the assembly is removed from the handle. To attach the assembly to the handle, it merely is pushed on the handle.