Abstract: An automatic surgical clip applier includes a handle assembly having an actuating member for causing a first member to move sequentially in a distal direction and a proximal direction, and for causing a second member to move sequentially in a proximal direction and a distal direction; and a clip applier assembly adapted for releasably securing to the handle assembly and having a jaw closing member and a clip feeding member, the jaw closing member being engageable with the first member and the clip feeding member being engageable with the second member.