Abstract: The present invention is based at least in part on the discovery of associations between polymorphic regions and specific diseases or disorders, e.g., abnormal lipid levels, e.g., abnormally low HDL-C levels, or diseases or disorders associated with abnormal lipid levels, e.g., vascular or metabolic diseases or disorders. Accordingly, the invention provides nucleic acid molecules having a nucleotide sequence of an allelic variant of a gene listed in Tables 1-5. The invention also provides methods for identifying specific alleles of polymorphic regions of a gene listed in Tables 1-5, methods for determining whether a subject has or is at risk of developing a disease which is associated with a specific allele of a polymorphic region of a gene listed in Tables 1-5, e.g., abnormal lipid levels, e.g., abnormally low HDL-C levels, or a vascular or metabolic disease or disorder, based on detection of one or more polymorphisms within the genes listed in Tables 1-5, and kits for performing such methods.

Abstract: The present invention is based, at least in part, on the identification of associations between polymorphic regions of the CD36L1 gene and specific diseases or disorders, e.g., abnormal lipid levels, e.g., abnormally high TG level or an abnormally high TG:HDL-C ratio, or diseases or disorders associated with abnormal lipid levels, e.g., vascular or metabolic diseases or disorders. The invention also provides methods for identifying specific alleles of polymorphic regions of a CD36L1 gene, methods for determining whether a subject has or is at risk of developing abnormal lipid levels, e.g., high TG level and high TG:HDL-C levels, or a disease or disorder associated therewith, e.g., a vascular disease or disorder or a metabolic disease or disorder, based on detection of one or more polymorphisms within the CD36L1 gene, and kits for performing such methods.

Abstract: The present invention is based at least in part on the discovery of a polymorphism within the interleukin 1 receptor antagonist (IL1RN) gene. Accordingly, the invention provides nucleic acid molecules having a nucleotide sequence of an allelic variant of an IL1RN gene. The invention also provides methods for identifying specific alleles of polymorphic regions of an IL1RN gene, methods for determining whether a subject has or is at risk of developing a disease which is associated with a specific allele of a polymorphic region of an IL1RN gene, e.g., a vascular disease, based on detection of a polymorphism within the IL1RN gene, and kits for performing such methods. The invention further provides methods for identifying a subject who has, or is at risk for developing, a vascular disease or disorder as a candidate for a particular clinical course of therapy or a particular diagnostic evaluation.

Abstract: The present invention is based at least in part on the discovery of polymorphisms within the endothelin-1 (EDN1) gene. Accordingly, the invention provides nucleic acid molecules having a nucleotide sequence of an allelic variant of an EDN1 gene. The invention also provides methods for identifying specific alleles of polymorphic regions of an EDN1 gene, methods for determining whether a subject has or is at risk of developing a disease which is associated with a specific allele of a polymorphic region of an EDN1 gene, e.g., a vascular disease, based on detection of one or more polymorphisms within the EDN1 gene, and kits for performing such methods. The invention further provides methods for identifying a subject who has, or is at risk for developing, a vascular disease or disorder as a candidate for a particular clinical course of therapy or a particular diagnostic evaluation.

Abstract: The present invention is based at least in part on the discovery of polymorphisms within the phospholipase C gamma 1 (PLCG1) gene and the plasminogen activator inhibitor type 2 (PAI-2) gene. Accordingly, the invention provides nucleic acid molecules having a nucleotide sequence of an allelic variant of a PLCG1 or PAI-2 gene. The invention also provides methods for identifying specific alleles of polymorphic regions of a PLCG1 or PAI-2 gene, methods for determining whether a subject is or is not at risk of developing a disease which is associated with a specific allele of a polymorphic region of a PLCG1 or PAI-2 gene, e.g., a vascular disease, based on detection of polymorphisms within the PLCG1 or PAI-2 gene, and kits for performing such methods. The invention further provides methods for classifying a subject who is or is not at risk for developing, a vascular disease or disorder as a candidate for a particular clinical course of therapy or a particular diagnostic evaluation.

Abstract: The present invention is based at least in part on the discovery of a polymorphism within the lysyl hydroxylase 2 (PLOD2) gene. Accordingly, the invention provides nucleic acid molecules having a nucleotide sequence of an allelic variant of a PLOD2 gene. The invention also provides methods for identifying specific alleles of polymorphic regions of a PLOD2 gene, methods for determining whether a subject is or is not at risk of developing a disease which is associated with a specific allele of a polymorphic region of a PLOD2 gene, e.g., a vascular disease, based on detection of polymorphisms within the PLOD2 gene, and kits for performing such methods. The invention further provides methods for classifying a subject who is or is not at risk for developing, a vascular disease or disorder as a candidate for a particular clinical course of therapy or a particular diagnostic evaluation.

Abstract: The present invention is based at least in part on the discovery of polymorphisms within the thrombospondin 2 (THBS2) gene, the angiotensin converting enzyme 1 (ACE), and the beta fibrinogen (FGB) gene. Accordingly, the invention provides nucleic acid molecules having a nucleotide sequence of an allelic variant of a THBS2, ACE, or FGB gene. The invention also provides methods for identifying specific alleles of polymorphic regions of a THBS2, ACE, or FGB gene, methods for determining whether a subject is or is not at risk of developing a disease which is associated with a specific allele of a polymorphic region of a THBS2, ACE, or FGB gene, e.g., a vascular disease, based on detection of polymorphisms within the THBS2, ACE, or FGB gene, and kits for performing such methods. The invention further provides methods for classifying a subject who is or is not at risk for developing, a vascular disease or disorder as a candidate for a particular clinical course of therapy or a particular diagnostic evaluation.

Abstract: The present invention is based at least in part on the discovery of polymorphisms within the Factor 2 (F2) gene. Accordingly, the invention provides nucleic acid molecules having a nucleotide sequence of an allelic variant of an F2 gene. The invention also provides methods for identifying specific alleles of polymorphic regions of an F2 gene, methods for determining whether a subject has or is at risk of developing a disease which is associated with a specific allele of a polymorphic region of an F2 gene, e.g., a vascular disease, based on detection of one or more polymorphisms within the F2 gene, and kits for performing such methods. The invention further provides methods for identifying a subject who has, or is at risk for developing, a vascular disease or disorder as a candidate for a particular clinical course of therapy or a particular diagnostic evaluation.

Abstract: The present invention is based at least in part on the discovery of polymorphisms within the thrombospondin 1 (THBS1) and thrombospondin 4 (THBS4) genes. Accordingly, the invention provides nucleic acid molecules having a nucleotide sequence of an allelic variant of a THBS1 or THBS4 gene. The invention also provides methods for identifying specific alleles of polymorphic regions of a THBS1 or THBS4 gene, methods for determining whether a subject has or is at risk of developing a disease which is associated with a specific allele of a polymorphic region of a THBS1 or THBS4 gene, e.g., a vascular disease, based on detection of polymorphisms within the THBS1 or THBS4 gene, and kits for performing such methods. The invention further provides methods for identifying a subject who has, or is at risk for developing, a vascular disease or disorder as a candidate for a particular clinical course of therapy or a particular diagnostic evaluation.

Abstract: The present invention is based at least in part on the discovery of polymorphisms within the integrin beta 3 (ITGB3), von Willebrand factor (VWF), endothelin receptor type B (EDNRB), factor 2 (F2), P-selectin (SELP), thrombospondin 1 (THBS 1), and thrombospondin 2 (THBS2) genes. Accordingly, the invention provides nucleic acid molecules having a nucleotide sequence of an allelic variant of a ITGB3, VWF, EDNRB, F2, SELP, THBS1, or THBS2 gene. The invention also provides methods for identifying specific alleles of polymorphic regions of a ITGB3, VWF, EDNRB, F2, SELP, THBS1, or THBS2 gene, methods for determining whether a subject has or is at risk of developing a disease which is associated with a specific allele of a polymorphic region of a ITGB3, VWF, EDNRB, F2, SELP, THBS1, or THBS2 gene, e.g., a vascular disease, based on detection of polymorphisms within the ITGB3, VWF, EDNRB, F2, SELP, THBS1, or THBS2 gene, and kits for performing such methods.

Abstract: The present invention is based at least in part on the discovery of polymorphisms within the Factor VII (F7) gene. Accordingly, the invention provides nucleic acid molecules having a nucleotide sequence of an allelic variant of an F7 gene. The invention also provides methods for identifying specific alleles of polymorphic regions of an F7 gene, methods for determining whether a subject has or is at risk of developing a disease which is associated with a specific allele of a polymorphic region of an F7 gene, e.g., a vascular disease, based on detection of one or more polymorphisms within the F7 gene, and kits for performing such methods. The invention further provides methods for identifying a subject who has, or is at risk for developing, a vascular disease or disorder as a candidate for a particular clinical course of therapy or a particular diagnostic evaluation.