Abstract: An edible fish oil is disclosed which contains EPA and DHA. This oil, with significantly reduced undesirable impurities, is obtained by subjecting fish oil to vacuum steam distillation contacting the oil with an adsorbent and recovering the oil. The oil can be combined with a vegetable oil and/or Rosemary extract antioxidant to improve its oxidative stability.
Type:
Grant
Filed:
October 2, 1989
Date of Patent:
June 11, 1991
Assignee:
Kabi Vitrum AB
Inventors:
Stephen S. Chang, Yongde Bao, Timothy J. Pelura
Abstract: The invention relates to a package protecting its contents from the influence of light, microbial contamination and gas transport in either direction but which makes possible a visual control of the contents before the package is used.According to the invention, the package is made of a light-proof outer bag (1) and a light permeable inner bag (3) arranged inside the outer bag. The outer bag (1) and the inner bag (3) are each sealed at one of their ends (2,4) and are bonded around their periphery (6) close to their other end, and the two bags extend over this bond and are then commonly joined and sealed. By opening one of the end seals in the outer bag (1), the inner bag (3) can be turned out of the outer bag, and the contents (5) of the package can be observed visually through the inner bag.The package of the invention is especially suitable for storage of preparations for parenteral administration and especially infusion solutions intended to be given intravenously.
Abstract: According to the invention, the parenteral administration of water-insoluble pharmacologically active agents is enhanced wherein the agents are administered in the lipoid phase of a carrier emulsion comprising a microemulsion of a finely dispersed lipoid in an aqueous phase. The lipoid preferably has a mean particle size below 1 micron. This makes it possible to administer water-insoluble agents in high concentrations, and thus a lower dose, whereby a rapid onset of the pharmacological effect is accompanied by a markedly reduced incidence of injury to body tissues.
Type:
Grant
Filed:
November 23, 1977
Date of Patent:
September 18, 1979
Assignee:
Apoteksvarucentralen Vitrum AB
Inventors:
Karl A. J. Wretlind, Stellan Ljungberg, Ivan Hakansson, Bengt M. Ajaxon
Abstract: Parenterally administrable oil-in-water emulsions formed from nutritive oils, such as soybean and sunflower oils, are improved first by treating the nutritive oil with silicic acid to remove undesirable components such as peroxides, pigments, thermal and oxidative decomposition products, certain unsaponifiable matter such as sterols, and polymers. Purification is effected by treating the oil with silicic acid or silica gel either directly, or as a solution thereof in a suitable solvent, such as hexane. Autoxidation of the purified oil is prevented by adding to the purified oil a tocopherol antioxidant, .gamma.-tocopherol being preferred. There is also added a metal scavenging agent such as ascorbyl palmitate.
Abstract: According to the method of the invention, the parenteral administration of water-insoluble pharmacologically active agents is enhanced wherein the agents are administered in the lipoid phase of a carrier emulsion comprising a microemulsion of a finely dispersed lipoid in an aqueous phase. The lipoid preferably has a mean particle size below 1 micron. This makes it possible to administer water-insoluble agents in high concentrations, and thus a lower dose, whereby a rapid onset of the pharmacological effect is accompanied by a markedly reduced incidence of injury to body tissues.
Type:
Grant
Filed:
March 12, 1976
Date of Patent:
February 14, 1978
Assignee:
Apoteksvarucentralen Vitrum AB
Inventors:
Karl A. J. Wretlind, Stellan Ljungberg, Ivan Hakansson, Bengt M. Ajaxon