Abstract: A device for detecting an analyte in a sample, which includes a radiation source adapted to generate electromagnetic radiation; a transducer capable of transducing a change in energy to an electrical signal; at least one tethered reagent on or proximal to the transducer, the tethered reagent having a binding site which is capable of binding the analyte; a chamber for holding the sample in fluid contact with transducer, wherein the chamber is adapted to contain the sample on inversion, partial inversion or agitation of the device; and a detector which is capable of detecting the electrical signal generated by the transducer.

Abstract: Disclosed herein is an analysis device for use with an external testing apparatus to detect the presence of an analyte in a test sample. The device comprises a transducer formed of a layer of pyroelectric or piezoelectric material sandwiched between first and second electrode layers, the transducer being arranged to produce an electrical voltage across the electrode layers in response to heating or straining of the pyroelectric or piezoelectric material layer. The device also comprises first and second stiffening elements for the transducer, the transducer being sandwiched between the stiffening elements. Each of the stiffening elements defines a planar surface for maintaining the transducer in a flat condition. Each of the stiffening elements exposes a portion of a respective electrode layer of the transducer for electrically connecting the transducer to the external text apparatus.

Abstract: The present invention relates to a method for detecting an analyte (10) in a sample, comprising the steps of: providing a transducer (3) having a pyroelectric or piezoelectric element and electrodes which is capable of transducing a change in energy to an electrical signal, a first reagent (9) immobilized on the transducer, the first reagent having a binding site which is capable of binding the analyte or a derivative of the analyte, exposing the sample to the transducer thereby allowing the analyte or a derivative of the analyte to bind to the first reagent to form a first reagent-analyte complex (13); introducing a second reagent (11), the second reagent having a binding site which is capable of selectively binding the first reagent-analyte complex, wherein the second reagent has a label (12) attached thereto which is capable of absorbing electromagnetic radiation to generate energy by non-radiative decay; irradiating the sample with electromagnetic radiation; transducing the energy generated into an electr

Abstract: The present application relates to a sensor (1) for use in detecting an analyte comprising: a transducer (10) composed of a pyroelectric or piezoelectric polymer substrate e.g. PVDF (3) and a transparent electrode layer (4) on a surface of the substrate; a layer of parylene (12) on the transparent electrode layer; and a reagent (17) immobilised on the transducer, the reagent having a binding site which is capable of binding the analyte or a derivative of the analyte.

Abstract: The present invention relates to a method for detecting an analyte (10) in a sample, comprising the steps of: providing a transducer comprising a pyroelectric or piezoelectric element and electrodes which is capable of transducing a change in energy to an electrical signal, a first reagent immobilised on the transducer, and a second reagent (11) releasably bound to the first reagent and having a label attached thereto which is capable of absorbing electromagnetic radiation to generate energy by non-radiative decay, wherein either the first or second reagent has a binding site which allows binding to the other and which is capable of preferentially binding to the analyte or a derivative of the analyte; exposing the transducer to the sample thereby allowing the analyte or a derivative of the analyte to bind to the binding site and displace the second reagent; irradiating the sample with electromagnetic radiation; transducing the energy generated into an electrical signal; and detecting the electrical signal.

Abstract: Disclosed herein is a sample collection device for an aqueous fluid, such as whole blood, serum, plasma and urine. The device comprises a cartridge body defining an elongate sample collection passage that has open ends. The passage is arranged to draw the fluid into the passage by capillary action. The passage is provided along a portion of its length with a sample metering stop in the form of a hydrophobic coating arranged to prevent flow of the fluid by capillary action thereacross. A sample receiving portion of the passage extending between a collection end and the metering stop is non-linear, and preferably defines a pair of straight limbs connected by a bend. By providing a non-linear passage in this way, the maximum gravitational force which can act on the collected sample is reduced as compared to a conventional linear passage, thereby reducing the tendency of the sample to leak from the device and potentially avoiding the need for one or both ends of the passage to be sealed.

Abstract: Disclosed herein is an analysis device for use with an external testing apparatus to detect the presence of an analyte in a test sample. The device comprises a transducer formed of a layer of pyroelectric or piezoelectric material sandwiched between first and second electrode layers, the transducer being arranged to produce an electrical voltage across the electrode layers in response to heating or straining of the pyroelectric or piezoelectric material layer. The device also comprises first and second stiffening elements for the transducer, the transducer being sandwiched between the stiffening elements. Each of the stiffening elements defines a planar surface for maintaining the transducer in a flat condition. Each of the stiffening elements exposes a portion of a respective electrode layer of the transducer for electrically connecting the transducer to the external text apparatus.

Abstract: The present application relates to a chemical sensing device for detecting an analyte in a liquid sample containing suspended particles. The device comprises a radiation source adapted to generate electromagnetic radiation, a transducer (3) having a pyroelectric or piezoelectric element and electrodes which is capable of transducing a change in energy to an electrical signal, at least one reagent (2) on or proximal to the transducer (3), the reagent being capable of absorbing the electromagnetic radiation to generate energy when in contact with the analyte, a chamber (9) for holding the sample in fluid contact with transducer, and a detector which is capable of detecting the electrical signal generated by the transducer. The transducer is in a plane from +45° to ?45° to the vertical.

Abstract: The present invention relates to a method for detecting an analyte (10) in a sample, comprising the steps of: (i) providing a transducer (3) comprising a pyroelectric or piezoelectric element and electrodes which is capable of transducing a change in energy to an electrical signal, and a first reagent (9) immobilised on the transducer, wherein the first reagent has a binding site which is capable of binding to a second reagent (11) in the presence of the analyte or a derivative of the analyte; (ii) introducing the second reagent, the second reagent having a binding site which is capable of binding the first reagent in the presence of the analyte or derivative thereof and having a label (12) attached thereto which is capable of absorbing electromagnetic radiation to generate energy by non-radiative decay, wherein either the first or the second reagent is capable of binding to the analyte or derivative thereof; (iii) exposing the sample to the transducer thereby allowing the analyte or derivative thereof to bin

Abstract: The present invention relates to a method for detecting an analyte (10) in a sample, comprising the steps of: providing a transducer comprising a pyroelectric or piezoelectric element and electrodes which is capable of transducing a change in energy to an electrical signal, a first reagent immobilised on the transducer, and a second reagent (11) releasably bound to the first reagent and having a label attached thereto which is capable of absorbing electromagnetic radiation to generate energy by non-radiative decay, wherein either the first or second reagent has a binding site which allows binding to the other and which is capable of preferentially binding to the analyte or a derivative of the analyte; exposing the transducer to the sample thereby allowing the analyte or a derivative of the analyte to bind to the binding site and displace the second reagent; irradiating the sample with electromagnetic adiation; transducing the energy generated into an electrical signal; and detecting the electrical signal.

Abstract: The present invention relates to a method for detecting an analyte (10) in a sample, comprising the steps of: providing a transducer (3) having a pyroelectric or piezoelectric element and electrodes which is capable of transducing a change in energy to an electrical signal, a first reagent (9) immobilised on the transducer, the first reagent having a binding site which is capable of binding the analyte or a derivative of the analyte, exposing the sample to the transducer thereby allowing the analyte or a derivative of the analyte to bind to the first reagent to form a first reagent-analyte complex (13); introducing a second reagent (11), the second reagent having a binding site which is capable of selectively binding the first reagent-analyte complex, wherein the second reagent has a label (12) attached thereto which is capable of absorbing electromagnetic radiation to generate energy by non-radiative decay; irradiating the sample with electromagnetic radiation; transducing the energy generated into an electr

Abstract: This invention relates to a method for detecting an analyte in a sample. The method comprises the steps of exposing the sample to a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing a change in energy to an electrical signal, the transducer having at least one reagent proximal thereto, the reagent having a binding site which is capable of binding the analyte or a complex or derivative of the analyte, wherein at least one of the analyte or the complex or derivative of the analyte has a label attached thereto which is capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; irradiating the reagent with a series of pulses of electromagnetic radiation, transducing the energy generated into an electrical signal; detecting the electrical signal and the time delay between each pulse of electromagnetic radiation from the radiation source and the generation of the electric signal.

Abstract: The present application relates to a chemical sensing device for detecting an analyte in a liquid sample containing suspended particles. The device comprises a radiation source adapted to generate electromagnetic radiation, a transducer (3) having a pyroelectric or piezoelectric element and electrodes which is capable of transducing a change in energy to an electrical signal, at least one reagent (2) on or proximal to the transducer (3), the reagent being capable of absorbing the electromagnetic radiation to generate energy when in contact with the analyte, a chamber (9) for holding the sample in fluid contact with transducer, and a detector which is capable of detecting the electrical signal generated by the transducer. The transducer is in a plane from +45° to ?45° to the vertical.

Abstract: The present invention relates to chemical sensing and in particular to a method for detecting an analyte in a sample of whole blood. The method comprise, in summary, the steps of: exposing the sample to a transducer having a tethered reagent; introducing a labelled reagent; irradiating the sample with a series of pulses of electromagnetic radiation at a wavelength of 600 run or above; and transducing and detecting the electrical signal and the time delay between each pulse. The label on the labelled reagent absorbs the electromagnetic radiation at a level which is at least equal to the absorption of the sample of whole blood at the wavelength of the electromagnetic radiation used.