Patents Assigned to Vivalis
  • Microwell array chip for detecting antigen-specific lymphocytes, method of detecting and method of manufacturing antigen-specific lymphocytes, and method of cloning antigen-specific lymphocyte antigen receptor genes
    Patent number: 8445193
    Abstract: A microwell array chip that has multiple microwells and is employed to contain a single lymphocyte specimen in each microwell and detect antigen-specific lymphocytes in single units; wherein the microwell array chip is of a shape and of dimensions where only one lymphocyte is contained in each microwell. A method of detecting antigen-specific lymphocytes comprising the steps of adding antigen to each microwell in the above microwell array chip, stimulating the lymphocyte specimen, and detecting lymphocyte specimens reacting with the antigen.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: May 21, 2013
    Assignee: Vivalis
    Inventors: Atsushi Muraguchi, Hiroyuki Kishi, Eiichi Tamiya, Masayasu Suzuki
  • Production of viral vaccines in suspension on avian embryonic derived stem cell lines
    Patent number: 8148132
    Abstract: The present invention relates to the development and manufacturing of viral vaccines, particularly the industrial production of viral vectors and vaccines, and more particularly the use of avian embryonic stem cells, preferably the EBx cell line derived from chicken embryonic stem cells, for the production of viral vectors and viruses; the invention is particularly useful for the industrial production of viral vaccines to prevent viral infection of humans and animals.
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: April 3, 2012
    Assignee: Vivalis
    Inventors: Majid Mehtali, Patrick Champion-Arnaud, Arnaud Leon
  • Production of poxviruses with adherent or non adherent avian cell lines
    Patent number: 7771980
    Abstract: The present invention relates to a method for replicating poxviruses such as vaccinia virus comprising the steps of inoculating avian embryonic stem cells with viral particles and culturing said cells in a basal medium until cells lysis occurs and newly produced viral particles are released in said medium.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: August 10, 2010
    Assignee: Vivalis
    Inventors: Fabienne Guehenneux, Bertrand Pain
  • Production of poxviruses with adherent or non adherent avian cell lines
    Patent number: 7432101
    Abstract: The present invention relates to a method for replicating pox viruses such as vaccinia virus comprising the steps of inoculating avian embryonic stem cells with viral particles and culturing said cells in a basal medium until cells lysis occurs and newly produced viral particles are released in said medium.
    Type: Grant
    Filed: July 22, 2004
    Date of Patent: October 7, 2008
    Assignee: Vivalis
    Inventors: Fabienne Guehenneux, Bertrand Pain