Abstract: An autoantigen identified as HP-8 which is related to systemic lupus erythematosus. The HP-8 antigen is expressed by a gene which was identified by immunoscreening of human placental cDNA GT11 expression library with the monoclonal antibody 3E10. The 3E10 antibody is a low-affinity anti-double-stranded DNA autoantibody derived from the MRL murine models for human systemic lupus erythematosus.
Type:
Grant
Filed:
April 12, 1995
Date of Patent:
September 15, 1998
Assignee:
VivoRx Autoimmune, Inc.
Inventors:
Cynthia K. French, Karen K. Yamamoto, Phoebe M. Chow, Negemias T. Alido