Abstract: A method for detection of an evoked response signal in noise including: generating a plurality of stimuli; receiving a noisy signal related to an evoked response to the plurality of stimuli; divide the noisy signal into a plurality of responses to the plurality of stimuli; estimate a statistic matrix for the plurality of responses; shrink the statistic matrix; calculate weights based on an inverse of the shrunk statistic matrix; apply weights to the plurality of responses to construct a final response; and output the final response. An apparatus having an input device configured to receive data related to a plurality of stimuli; and a processor configured to: receive a noisy signal and divide the noisy signal into a plurality of responses; estimate a statistic matrix; shrink the statistic matrix; calculate weights based on an inverse of the shrunk statistic matrix; and apply weights to the plurality of responses to construct a final response.

Abstract: A system and method for filtering a signal comprising: receiving a signal of interest; receiving a signal indicating that a stimulus has been applied; receiving the synchronized stimulus signal and signal of interest; recursively selecting a portion of the signal of interest associated with a stimulus being applied and assign the selected portion of the signal of interest to one of the plurality of buffers; combining all responses in each of said plurality of buffers; transforming the combination of all responses in each buffer to a transform space; comparing the transform components of the buffers to determine a scaling factor; applying the scaling factor to the spectral components of the buffers; performing an inverse transform on the result of combining the buffers to return to the time domain to produce a filtered signal, and outputting the filtered signal received from the processor.

Abstract: An apparatus, method and system for collection of physiological electrical potential signals. In one embodiment, an apparatus for use in measuring electrical potentials in a subject (e.g. an animal or a human), having an amplifier being removably mountable to a ground electrode and electrically coupled to at least two signal electrodes, wherein the amplifier is configured to communicate with a signal processing device and indicate if one of the at least two signal electrodes is poorly affixed to, or detached from, said subject. In another embodiment, the at least two signal electrodes comprise a first signal electrode and a second signal electrode, and the amplifier is configured to detect differential electrical potential signals presented by the first signal electrode and the second signal electrode, amplify the differential electrical potential signals by a predetermined gain level to generate an amplified signal, and transmit the amplified signal to the signal processing device.

Abstract: A system and method for use in a real time system and for processing a signal with a low signal-to-noise ratio (SNR). The system comprises a model for modeling an expected signal and a filter that uses the model for filtering the signal. The filter is used for generating a prediction of the signal and an error variance matrix. The system further comprises an adaptive element for modifying the error variance matrix such that the bandwidth of the filter is widened, wherein the filter behaves like an adaptive filter.

Abstract: An apparatus, method and system for collection of physiological electrical potential signals. In one embodiment, an apparatus for use in measuring electrical potentials in a subject (e.g. an animal or a human), having an amplifier being removably mountable to a ground electrode and electrically coupled to at least two signal electrodes, wherein the amplifier is configured to communicate with a signal processing device and indicate if one of the at least two signal electrodes is poorly affixed to, or detached from, said subject. In another embodiment, the at least two signal electrodes comprise a first signal electrode and a second signal electrode, and the amplifier is configured to detect differential electrical potential signals presented by the first signal electrode and the second signal electrode, amplify the differential electrical potential signals by a predetermined gain level to generate an amplified signal, and transmit the amplified signal to the signal processing device.

Abstract: An invention is disclosed that provides an apparatus, method and system for the collection of physiological electrical potential signals. In one embodiment, the apparatus comprises integrating amplifier and an electrode into a combined unit for attaching or affixing to a subject (e.g., an animal or a human). Resulting from the extremely small or short connection between the conductive portion of the electrode and the amplifier, significantly less noise is introduced into the signal detected by the amplifier. The amplifier thus amplifies a signal with a much higher signal-to-noise ratio as compared with conventional electrode to lead wire to amplifier arrangements.

Abstract: A method and system for modulating a steady state stimulus involving first generating a steady state stimulus signal and then modulating the steady state stimulus signal by at least a portion of a sinusoidal signal where the stimulus is set to zero during another portion of the sinusoidal signal. The steady state stimulus may also be offset by the addition of a constant or may be passed through a bandpass filter to reduce or eliminate frequency components that are outside the desired range of stimulation.

Abstract: A system and method for filtering and detecting faint signals in noise by placing a filter prior to an amplifier. In particular, a system for filtering differential signals includes: a signal receiver for receiving a differential signal; a prefiltering network connected to the receiver for filtering the differential signal prior to amplification, the prefiltering network including a high-pass filter and/or a low-pass filter; and an amplifier connected to the filtering network. In contrast with the conventional approach of connecting the filter to the amplifier's inputs, the filtering network in a preferred embodiment of the invention is connected to the amplifier through the amplifier's gain resistor such that the input impedance and common mode rejection ratio of the amplifier is not adversely affected by the filtering. Band-pass filtering prior to amplification reduces the noise in the signal and allows higher gain to provide a clearer signal following amplification.

Abstract: A system and method for use in a real time system and for processing a signal with a low signal-to-noise ratio (SNR). The system comprises a model for modeling an expected signal and a filter that uses the model for filtering the signal. The filter is used for generating a prediction of the signal and an error variance matrix. The system further comprises an adaptive element for modifying the error variance matrix such that the bandwidth of the filter is widened, wherein the filter behaves like an adaptive filter.