Patents Assigned to Vivus Incorporated
  • Method and kit for preventing erectile dysfunction
    Patent number: 5820587
    Abstract: A method is provided for preventing erectile dysfunction, particularly vasculogenic impotence, in a male individual. The method involves periodic administration of a vasoactive agent throughout a 24-hour period. The agent and dosage regimen are selected such that regularly increased blood flow to the penis is achieved, in turn preventing arterial occlusion and vascular deterioration of the muscular fibers of the vessels and collagen fibers of the cavernosal tissue.
    Type: Grant
    Filed: March 17, 1997
    Date of Patent: October 13, 1998
    Assignee: Vivus Incorporated
    Inventor: Virgil A. Place
  • Process for preparing prostaglandin E1, E2 and analogs thereof using furylcopper reagents
    Patent number: 5618959
    Abstract: A process for synthesizing prostaglandin E.sub.1, E.sub.2 and derivatives thereof is provided. The process is a "one-pot" method in which 2-furyllithium, copper cyanide, a lower alkyllithium reagent and either an (E)-alkenylstannane or a halogenide are combined with cyclopentenone (II) ##STR1## in which A, R.sup.6 and R.sup.7 are as defined herein. The reaction gives rise to the desired prostaglandin product in yields of 80% or higher.
    Type: Grant
    Filed: March 10, 1995
    Date of Patent: April 8, 1997
    Assignee: Vivus Incorporated
    Inventors: Miroslav Trampota, Bohumil Zak