Patents Assigned to Vivus Incorporated
  • Administration of 5-HT.sub.3 receptor antagonists to treat premature ejaculation
    Patent number: 6037360
    Abstract: A method is provided for delaying the onset of ejaculation in an individual. The method involves administration of a 5-HT.sub.3 receptor antagonist within the context of an effective dosing regimen. The preferred mode of administration is transurethral; however, the selected inhibitor may also be delivered via intracavernosal injection or using alternative routes.
    Type: Grant
    Filed: October 28, 1997
    Date of Patent: March 14, 2000
    Assignee: Vivus, Incorporated
    Inventors: William L. Smith, Paul C. Doherty, Jr., Virgil A. Place
  • Venous flow control element for maintaining penile erection
    Patent number: 5855548
    Abstract: A venous flow control device is provided for assisting in the maintenance of a penile erection or in preventing urinary incontinence. The device is a tubular structure adapted to be secured in a loop configuration about the penis to provide an adjustable radial constrictive force about the base of the penis. Methods for using the device are also provided.
    Type: Grant
    Filed: January 10, 1997
    Date of Patent: January 5, 1999
    Assignee: Vivus, Incorporated
    Inventor: Virgil A. Place
  • Method and kit for preventing erectile dysfunction
    Patent number: 5820587
    Abstract: A method is provided for preventing erectile dysfunction, particularly vasculogenic impotence, in a male individual. The method involves periodic administration of a vasoactive agent throughout a 24-hour period. The agent and dosage regimen are selected such that regularly increased blood flow to the penis is achieved, in turn preventing arterial occlusion and vascular deterioration of the muscular fibers of the vessels and collagen fibers of the cavernosal tissue.
    Type: Grant
    Filed: March 17, 1997
    Date of Patent: October 13, 1998
    Assignee: Vivus Incorporated
    Inventor: Virgil A. Place
  • Process for preparing prostaglandin E1, E2 and analogs thereof using furylcopper reagents
    Patent number: 5618959
    Abstract: A process for synthesizing prostaglandin E.sub.1, E.sub.2 and derivatives thereof is provided. The process is a "one-pot" method in which 2-furyllithium, copper cyanide, a lower alkyllithium reagent and either an (E)-alkenylstannane or a halogenide are combined with cyclopentenone (II) ##STR1## in which A, R.sup.6 and R.sup.7 are as defined herein. The reaction gives rise to the desired prostaglandin product in yields of 80% or higher.
    Type: Grant
    Filed: March 10, 1995
    Date of Patent: April 8, 1997
    Assignee: Vivus Incorporated
    Inventors: Miroslav Trampota, Bohumil Zak