Patents Assigned to Vlaamse Instelling Technologisch Onderzoek (V.I.T.O.)
  • Recombinant nucleic acid sequences and methods for determining both genotoxicity and mutagenicity of a sample and the kinetics of the genotoxicity
    Patent number: 6602666
    Abstract: A recombinant nucleic acid sequence comprising an SOS regulated promoter with an induction ratio higher than 40, said promoter being operatively linked to a reporter encoding nucleic acid sequence encoding a reporter resulting in a signal that can be assayed as light production. A biosensor comprising such a nucleic acid sequence and methods for determining genotoxicity and the presence of multiple genotoxic compounds using such a biosensor are disclosed.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: August 5, 2003
    Assignee: Vlaamse Instelling Technologisch Onderzoek (V.I.T.O.)
    Inventors: Daniel Van Der Lelie, Brigitte Marie Francoise Borremans, Ann Irma Alice Provoost, Luc Agnes Louis Jean Bosco Regniers, Luc Philipinne Edouard Verschaeve