Patents Assigned to VLife Sciences Technologies Pvt. Ltd.
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Patent number: 8741953Abstract: This invention relates to a new topical gel formulation of the drug Esmolol hydrochloride for treatment of chronic wounds such as diabetic wounds, burn wounds, venous ulcers and pressure ulcers.Type: GrantFiled: September 21, 2010Date of Patent: June 3, 2014Assignee: Vlife Sciences Technologies Pvt. Ltd.Inventors: Supreet K Deshpande, Sudhir A. Kulkarni, Reena Gollapudy
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Patent number: 8686051Abstract: A method for treating diabetic complications by administration of a beta-blocker is disclosed. Diabetic complications arise from diabetes and have few or no existing treatment options. The present invention describes the use of a beta-blocker in the treatment of a diabetic. The present invention also describes the inhibition of aldose reductase, one of the chief causative factors of diabetic complications. Also provided are methods of diabetic wound healing. Compositions for treating diabetic complications, such as diabetic wounds, are disclosed. The present invention includes employing a topical formulation of a beta-blocker, having substantially no antibacterial activity, to improve the process of diabetic wound healing. The present invention also involves increasing the rate of collagen accumulation of the healing epithelialized tissue in the wound of a diabetic individual.Type: GrantFiled: January 24, 2008Date of Patent: April 1, 2014Assignee: VLife Sciences Technologies Pvt. Ltd.Inventors: Supreet K. Deshpande, Sudhir A. Kulkarni, Reena R. Gollapudy
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Publication number: 20120196930Abstract: This invention relates to a new topical gel formulation of the drug Esmolol hydrochloride for treatment of chronic wounds such as diabetic wounds, burn wounds, venous ulcers and pressure ulcers.Type: ApplicationFiled: September 21, 2010Publication date: August 2, 2012Applicant: VLIFE SCIENCES TECHNOLOGIES PVT. LTD.Inventors: Supreet K. Deshpande, Sudhir A. Kulkarni, Reena Gollapudy
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Publication number: 20110021485Abstract: Provided are compounds which are indole derivatives, as well as pharmaceutical compositions containing the compounds. Also provided are methods of using the indole compounds for preventing or treating a disease, or a condition that predisposes to a disease, wherein the disease or condition is associated with activation of the serine/threonine kinase B (Akt) in an animal. The method comprises administering to the animal a preventive or treatment effective amount of the indole compound. Further provided is a method for increasing apoptosis of an animal cell comprising contacting the cell with the indole compound.Type: ApplicationFiled: July 28, 2010Publication date: January 27, 2011Applicant: VLife Sciences Technologies Pvt. Ltd.Inventors: Sudhir Appaji Kulkarni, Supreet K. Deshpande
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Publication number: 20110021526Abstract: A method for treating diabetic complications by administration of a beta-blocker is disclosed. Diabetic complications arise from diabetes and have few or no existing treatment options. The present invention describes the use of a beta-blocker in the treatment of a diabetic. The present invention also describes the inhibition of aldose reductase, one of the chief causative factors of diabetic complications. Also provided are methods of diabetic wound healing. Compositions for treating diabetic complications, such as diabetic wounds, are disclosed. The present invention includes employing a topical formulation of a beta-blocker, having substantially no antibacterial activity, to improve the process of diabetic wound healing. The present invention also involves increasing the rate of collagen accumulation of the healing epithelialized tissue in the wound of a diabetic individual.Type: ApplicationFiled: January 24, 2008Publication date: January 27, 2011Applicant: VLife Science Technologies Pvt. Ltd.Inventor: Supreet K. Deshpande
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Patent number: 7781480Abstract: Provided are compounds which are indole derivatives, as well as pharmaceutical compositions containing the compounds. Also provided are methods of using the indole compounds for preventing or treating a disease, or a condition that predisposes to a disease, wherein the disease or condition is associated with activation of the serine/threonine kinase B (Akt) in an animal. The method comprises administering to the animal a preventive or treatment effective amount of the indole compound. Further provided is a method for increasing apoptosis of an animal cell comprising contacting the cell with the indole compound.Type: GrantFiled: August 10, 2007Date of Patent: August 24, 2010Assignee: VLife Sciences Technologies Pvt. Ltd.Inventors: Sudhir Appajl Kulkarni, Supreet Deshpande
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Publication number: 20100010955Abstract: Group based QSAR method (G-QSAR) is reported which uses descriptors evaluated only for the substituent groups or molecular fragments rather than whole molecule for generating QSAR. In addition, cross terms are calculated from product of descriptors at different substituent sites or fragments and used as descriptors to improve the QSAR models. This method provides QSAR models with predictive ability similar or better to conventional methods and in addition provides hints for sites or fragments of improvement in the molecules. The descriptor ranges for substituents or fragments are used to search for new groups/fragments leading to design of novel molecules with improved activity/property.Type: ApplicationFiled: January 16, 2008Publication date: January 14, 2010Applicant: VLIFE Sciences Technologies PVT Ltd.Inventor: Supreet K. Deshpande
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Publication number: 20080242652Abstract: Provided are compounds which are indole derivatives, as well as pharmaceutical compositions containing the compounds. Also provided are methods of using the indole compounds for preventing or treating a disease, or a condition that predisposes to a disease, wherein the disease or condition is associated with activation of the serine/threonine kinase B (Akt) in an animal. The method comprises administering to the animal a preventive or treatment effective amount of the indole compound. Further provided is a method for increasing apoptosis of an animal cell comprising contacting the cell with the indole compound.Type: ApplicationFiled: August 10, 2007Publication date: October 2, 2008Applicant: VLife Sciences Technologies Pvt. Ltd.Inventors: Sudhir Appaji Kulkarni, Supreet Deshpande