Patents Assigned to VLP THERAPEUTICS, LLC
  • MALARIA VACCINE
    Publication number: 20190351041
    Abstract: The present invention provides a particle comprising a polypeptide and at least one malaria antigen, and a composition or vaccine comprising thereof, its use in medicine, particularly in the prevention or treatment of malaria infections.
    Type: Application
    Filed: March 28, 2019
    Publication date: November 21, 2019
    Applicant: VLP Therapeutics, LLC
    Inventors: Ryuji UENO, Wataru AKAHATA
  • Virus like particle comprising PD-1 antigen or PD-1 ligand antigen
    Patent number: 10464986
    Abstract: The present invention provides a virus like particle comprising a virus structural protein and an antigen derived from PD-1 or a ligand of PD-1, and a composition or kit comprising thereof, its use in immune response etc.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: November 5, 2019
    Assignee: VLP Therapeutics, LLC
    Inventors: Wataru Akahata, Ryuji Ueno
  • Virus like particle comprising modified envelope protein E3
    Patent number: 10385101
    Abstract: A virus like particle comprising a viral structural protein which comprises modified envelope protein E3. The viral structural protein may be that derived from or alphavirus or flavivirus. Especially, the viral structural protein may be derived from Chikungunya virus or Venezuelan equine encephalitis virus.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: August 20, 2019
    Assignee: VLP Therapeutics, LLC
    Inventors: Wataru Akahata, Ryuji Ueno
  • ALPHAVIRUS REPLICON PARTICLE
    Publication number: 20190185822
    Abstract: Provided is an alphavirus replicon particle (ARP), which comprises (i) alphavirus structural proteins comprising capsid and/or envelope, and (ii) an alphavirus replicon comprising a polynucleotide encoding alphavirus non-structural proteins nsp1, nsp2, nsp3 and nsp4 and at least one gene of interest wherein at least one of capsid, and E3 and E2 in the envelope comprise one or more amino acid alteration but E1 in the envelope comprises no amino acid alteration.
    Type: Application
    Filed: December 19, 2018
    Publication date: June 20, 2019
    Applicant: VLP Therapeutics, LLC
    Inventors: Wataru Akahata, Ryuji Ueno
  • Method and composition for modulating immune response
    Patent number: 10166281
    Abstract: Provided is a method for modulating an immune response which is not derived from alphavirus infection comprising administering to a subject in need thereof an effective amount of a composition comprising an alphavirus virus like particle.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: January 1, 2019
    Assignee: VLP Therapeutics, LLC
    Inventors: Wataru Akahata, Ryuji Ueno
  • Flavivirus virus like particle
    Patent number: 10098943
    Abstract: Provided is a virus like particle comprising one or more flavivirus structural proteins, and a composition or vaccine comprising thereof, its use in the prevention or treatment of flavivirus infection. The flavivirus structural protein contains at least one amino acid alteration in the envelope region. Examples of flavivirus contains dengue virus.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: October 16, 2018
    Assignee: VLP Therapeutics, LLC
    Inventors: Wataru Akahata, Ryuji Ueno
  • Virus like particle comprising modified envelope protein E3
    Patent number: 9969986
    Abstract: A virus like particle comprising a viral structural protein which comprises modified envelope protein E3. The viral structural protein may be that derived from or alphavirus or flavivirus. Especially, the viral structural protein may be derived from Chikungunya virus or Venezuelan equine encephalitis virus.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: May 15, 2018
    Assignee: VLP Therapeutics, LLC
    Inventors: Wataru Akahata, Ryuji Ueno
  • ZIKA VIRUS VIRUS LIKE PARTICLE
    Publication number: 20170252425
    Abstract: Provided is a virus like particle comprising one or more zika virus structural proteins, and a composition or vaccine comprising thereof, its use in the prevention or treatment of zika virus disease. The zika virus structural protein contains at least one amino acid alteration in the envelope protein.
    Type: Application
    Filed: March 3, 2017
    Publication date: September 7, 2017
    Applicant: VLP Therapeutics, LLC
    Inventors: Wataru AKAHATA, Ryuji UENO
  • VIRUS LIKE PARTICLE COMPRISING PD-1 ANTIGEN OR PD-1 LIGAND ANTIGEN
    Publication number: 20170233450
    Abstract: The present invention provides a virus like particle comprising a virus structural protein and an antigen derived from PD-1 or a ligand of PD-1, and a composition or kit comprising thereof, its use in immune response etc.
    Type: Application
    Filed: April 27, 2017
    Publication date: August 17, 2017
    Applicant: VLP Therapeutics, LLC
    Inventors: Wataru AKAHATA, Ryuji UENO
  • Virus like particle comprising PD-1 antigen or PD-1 ligand antigen
    Patent number: 9637532
    Abstract: The present invention provides a virus like particle comprising a virus structural protein and an antigen derived from PD-1 or a ligand of PD-1, and a composition or kit comprising thereof, its use in immune response etc.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: May 2, 2017
    Assignee: VLP Therapeutics, LLC
    Inventors: Wataru Akahata, Ryuji Ueno
  • METHOD AND COMPOSITION FOR MODULATING IMMUNE RESPONSE
    Publication number: 20170065703
    Abstract: Provided is a method for modulating an immune response which is not derived from alphavirus infection comprising administering to a subject in need thereof an effective amount of a composition comprising an alphavirus virus like particle.
    Type: Application
    Filed: September 2, 2016
    Publication date: March 9, 2017
    Applicant: VLP Therapeutics, LLC
    Inventors: Wataru AKAHATA, Ryuji UENO
  • MALARIA VACCINE
    Publication number: 20170035871
    Abstract: The present invention provides a particle comprising a polypeptide and at least one malaria antigen, and a composition or vaccine comprising thereof, its use in medicine, particularly in the prevention or treatment of malaria infections.
    Type: Application
    Filed: October 21, 2016
    Publication date: February 9, 2017
    Applicant: VLP Therapeutics, LLC
    Inventors: Ryuji UENO, Wataru AKAHATA
  • VIRUS LIKE PARTICLE COMPRISING MODIFIED ENVELOPE PROTEIN E3
    Publication number: 20160200775
    Abstract: A virus like particle comprising a viral structural protein which comprises modified envelope protein E3. The viral structural protein may be that derived from or alphavirus or flavivirus. Especially, the viral structural protein may be derived from Chikungunya virus or Venezuelan equine encephalitis virus.
    Type: Application
    Filed: January 7, 2016
    Publication date: July 14, 2016
    Applicant: VLP Therapeutics, LLC
    Inventors: Wataru AKAHATA, Ryuji UENO
  • VIRUS LIKE PARTICLE COMPOSITION
    Publication number: 20160090403
    Abstract: The present invention provides a particle comprising a polypeptide and at least one antigen, and a composition comprising thereof.
    Type: Application
    Filed: December 8, 2015
    Publication date: March 31, 2016
    Applicant: VLP Therapeutics, LLC
    Inventors: Ryuji UENO, Wataru AKAHATA
  • Flavivirus virus like particle
    Publication number: 20160074501
    Abstract: Provided is a virus like particle comprising one or more flavivirus structural proteins, and a composition or vaccine comprising thereof, its use in the prevention or treatment of flavivirus infection. The flavivirus structural protein contains at least one amino acid alteration in the envelope region. Examples of flavivirus contains dengue virus.
    Type: Application
    Filed: September 10, 2015
    Publication date: March 17, 2016
    Applicant: VLP THERAPEUTICS, LLC
    Inventors: Wataru AKAHATA, Ryuji UENO
  • VIRUS LIKE PARTICLE COMPRISING MODIFIED ENVELOPE PROTEIN E3
    Publication number: 20160040134
    Abstract: A virus like particle comprising a viral structural protein which comprises modified envelope protein E3. The viral structural protein may be that derived from or alphavirus or flavivirus. Especially, the viral structural protein may be derived from Chikungunya virus or Venezuelan equine encephalitis virus.
    Type: Application
    Filed: August 7, 2015
    Publication date: February 11, 2016
    Applicant: VLP THERAPEUTICS, LLC
    Inventors: Wataru AKAHATA, Ryuji UENO
  • Virus like particle composition
    Patent number: 9249191
    Abstract: The present invention provides a particle comprising a polypeptide and at least one antigen, and a composition comprising thereof.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: February 2, 2016
    Assignee: VLP Therapeutics, LLC
    Inventors: Ryuji Ueno, Wataru Akahata
  • VIRUS LIKE PARTICLE COMPRISING PD-1 ANTIGEN OR PD-1 LIGAND ANTIGEN
    Publication number: 20150017194
    Abstract: The present invention provides a virus like particle comprising a virus structural protein and an antigen derived from PD-1 or a ligand of PD-1, and a composition or kit comprising thereof, its use in immune response etc.
    Type: Application
    Filed: July 10, 2014
    Publication date: January 15, 2015
    Applicant: VLP THERAPEUTICS, LLC
    Inventors: Wataru AKAHATA, Ryuji UENO
  • MALARIA VACCINE
    Publication number: 20140363458
    Abstract: The present invention provides a particle comprising a polypeptide and at least one malaria antigen, and a composition or vaccine comprising thereof, its use in medicine, particularly in the prevention or treatment of malaria infections.
    Type: Application
    Filed: June 3, 2014
    Publication date: December 11, 2014
    Applicant: VLP THERAPEUTICS, LLC
    Inventors: Ryuji UENO, Wataru AKAHATA
  • VIRUS LIKE PARTICLE COMPOSITION
    Publication number: 20130251744
    Abstract: The present invention provides a particle comprising a polypeptide and at least one antigen, and a composition comprising thereof.
    Type: Application
    Filed: February 15, 2013
    Publication date: September 26, 2013
    Applicant: VLP THERAPEUTICS, LLC
    Inventors: Ryuji UENO, Wataru AKAHATA