Abstract: The present application proposes an over-voltage protection circuit for a USB Type-C connector. The USB Type-C connector has at least one input signal pin. The over-voltage protection circuit includes a control circuit, a voltage level shift circuit, and a system clamping circuit. The control circuit generates a control signal according to a bias voltage. The voltage level shift circuit is electrically connected to the at least one input signal pin and the control circuit, and arranged to receive the control signal and at least one input signal and the control signal from the at least one input signal pin, and regulate a voltage level of the at least one input signal according to the control signal. The system clamping circuit is electrically connected to the level shift circuit, and clamps the voltage level of the regulated input signal down to below a threshold.