Abstract: Provided is a triple agonist for the glucagon-like peptide-1 receptor (GLP1-R), glucagon receptor (GCGR), and gastric inhibitory polypeptide receptor (GIPR), the triple agonist being based on the amino acid sequence of natural exendin-4 with at least one site having an amino acid substitution, mutation, or chemical modification. The triple agonist of the present invention can be used for the prevention or treatment of metabolic syndrome.