Patents Assigned to Voyager Therapeutics, Inc.
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Patent number: 11951121Abstract: The present invention relates to small interfering RNA (siRNA) molecules against the HTT gene, adeno-associated viral (AAV) vectors encoding siRNA molecules and methods for treating Huntington's Disease (HD) using the siRNA molecules and AAV vectors.Type: GrantFiled: May 18, 2017Date of Patent: April 9, 2024Assignee: VOYAGER THERAPEUTICS, INC.Inventors: Dinah Wen-Yee Sah, Jinzhao Hou, Pengcheng Zhou, Xin Wang, Jochen Deckert, Markus Hossbach
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Patent number: 11931375Abstract: The present disclosure relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and delivery methods for the treatment of spinal cord related disorders including ALS.Type: GrantFiled: March 22, 2022Date of Patent: March 19, 2024Assignee: Voyager Therapeutics, Inc.Inventors: Dinah Wen-Yee Sah, Holger Patzke, Qingmin Chen, Jenna Carroll Soper
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Patent number: 11859200Abstract: The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.Type: GrantFiled: October 26, 2021Date of Patent: January 2, 2024Assignee: VOYAGER THERAPEUTICS, INC.Inventors: Mathieu E. Nonnenmacher, Jinzhao Hou, Wei Wang, Matthew Child, Shaoyong Li
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Patent number: 11759506Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides encoding AADC for the treatment of Parkinson's Disease.Type: GrantFiled: July 26, 2019Date of Patent: September 19, 2023Assignee: Voyager Therapeutics, Inc.Inventors: Maria Scheel, Bernard Ravina
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Patent number: 11752181Abstract: The present invention relates to adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating Huntington's Disease (HD).Type: GrantFiled: May 4, 2018Date of Patent: September 12, 2023Assignee: VOYAGER THERAPEUTICS, INC.Inventors: Dinah Wen-Yee Sah, Fen Chen, Pengcheng Zhou, Xin Wang, Yanqun Shu, Jinzhao Hou, Jochen Deckert, Markus Hossbach
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Patent number: 11697825Abstract: The present invention is directed to viral vectors and methods of their production and use.Type: GrantFiled: December 11, 2015Date of Patent: July 11, 2023Assignee: Voyager Therapeutics, Inc.Inventors: James McLaughlin, Robert Kotin
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Patent number: 11603542Abstract: The present invention relates to adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating amyotrophic lateral sclerosis (ALS).Type: GrantFiled: May 4, 2018Date of Patent: March 14, 2023Assignee: Voyager Therapeutics, Inc.Inventors: Dinah Wen-Yee Sah, Qingmin Chen, Jinzhao Hou
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Patent number: 11542506Abstract: The present invention relates to small interfering RNA (siRNA) molecules against the SOD1 gene, adeno-associated viral (AAV) vectors encoding siRNA molecules and methods for treating amyotrophic lateral sclerosis (ALS) using the siRNA molecules and AAV vectors.Type: GrantFiled: January 6, 2021Date of Patent: January 3, 2023Assignee: Voyager Therapeutics, Inc.Inventors: Dinah Wen-Yee Sah, Jinzhao Hou, Mathieu E. Nonnenmacher, Pengcheng Zhou, Markus Hossbach, Jochen Deckert
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Publication number: 20220395544Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like pol peptides, for the prevention and/or treatment of diseases and/or disorders.Type: ApplicationFiled: April 8, 2022Publication date: December 15, 2022Applicant: Voyager Therapeutics, Inc.Inventors: Steven Paul, Donna T. Ward
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Patent number: 11512327Abstract: The invention provides compositions and methods for the preparation, manufacture, formulation and therapeutic use of adeno-associated virus (AAV) particles for the prevention and/or treatment of diseases.Type: GrantFiled: August 3, 2018Date of Patent: November 29, 2022Assignee: Voyager Therapeutics, Inc.Inventors: Dinah Wen-Yee Sah, Holger Patzke, Jinzhao Hou, Mathieu E. Nonnenmacher, Martin Goulet, Todd Carter
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Publication number: 20220364114Abstract: The present disclosure describes methods and systems for use in the production of adeno-associated virus (AAV) particles, including recombinant adeno-associated virus (rAAV) particles. In certain embodiments, the production process and system use Spodoptera frugiperda insect cells (such as Sf9 or Sf21) as viral production cells. In certain embodiments, the production process and system use Baculoviral Expression Vectors (BEVs) in the production of AAV particles. In certain embodiments, the production process and system allow for the controlled expression of AAV capsid proteins, such as VP1, VP2 and VP3.Type: ApplicationFiled: August 26, 2020Publication date: November 17, 2022Applicants: VOYAGER THERAPEUTICS, INC., VOYAGER THERAPEUTICS, INC.Inventors: Jeffrey Morley Slack, Andrade Hendricks, Peter Slade, Christopher Nguyen
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Patent number: 11497576Abstract: The present disclosure presents a trajectory array guide system for defining a trajectory to a target location in the brain of a subject and for guiding an elongated tool along the trajectory. The trajectory array guide system can comprise: a base, an array guide, an imaging unit, and an elongated handle configured for connection with a stereotaxic navigation system. The present disclosure presents a method of using a trajectory array guide system for defining a trajectory to a target location in the brain of a subject and for guiding an elongated tool along the trajectory.Type: GrantFiled: July 17, 2018Date of Patent: November 15, 2022Assignees: Voyager Therapeutics, Inc., The Regents of the University of CaliforniaInventors: Adrian Philip Kells, Stefan Schreck, Edward H. Luttich, Kenneth A. Bloch, Krystof Bankiewicz
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Publication number: 20220339270Abstract: The disclosure provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.Type: ApplicationFiled: April 29, 2020Publication date: October 27, 2022Applicant: Voyager Therapeutics, Inc.Inventors: Wencheng Liu, Todd Carter, Jinzhao Hou, Yanqun Shu, Giridhar Murlidharan, Martin Goulet, Dinah Wen-Yee Sah, Steven Paul, Xiao-Qin Ren, Xin Wang, Hiu Yan Chung
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Patent number: 11434502Abstract: The present invention relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and/or canine degenerative myelopathy (DM).Type: GrantFiled: October 16, 2018Date of Patent: September 6, 2022Assignee: Voyager Therapeutics, Inc.Inventors: Dinah Wen-Yee Sah, Qingmin Chen, Holger Patzke, Jinzhao Hou
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Publication number: 20220195456Abstract: Aspects of the disclosure relate to a nucleic acid comprising a heterologous nucleic acid insert flanked by interrupted self-complementary sequences, wherein one self-complementary sequence is interrupted by a cross-arm sequence forming two opposing, lengthwise-symmetric stem-loops, and wherein the other of the self-complementary sequences is interrupted by a truncated cross-arm sequence. Methods of delivering the nucleic acid to a cell are also provided.Type: ApplicationFiled: June 1, 2021Publication date: June 23, 2022Applicants: University of Massachusetts, Voyager Therapeutics, Inc.Inventors: Robert M. Kotin, Sylvain Cecchini
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Patent number: 11326182Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody like polypeptides, for the prevention and/or treatment of diseases and/or disorders.Type: GrantFiled: April 28, 2017Date of Patent: May 10, 2022Assignee: Voyager Therapeutics, Inc.Inventors: Steven Paul, Donna T. Ward
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Patent number: 11299751Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.Type: GrantFiled: April 28, 2017Date of Patent: April 12, 2022Assignee: Voyager Therapeutics, Inc.Inventors: Steven Paul, Donna T. Ward
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Patent number: 11298041Abstract: The present disclosure provides methods for targeting a biomedical system. Aspects of the subject methods include determining the trajectory of a targeting device using magnetic resonance imaging (MRI) of a MRI-visible style of a trajectory guide that is compatible with the targeting device. Targeted biomedical systems may be utilized for a variety of purposes including targeted delivery of a therapeutic, holding a therapeutic device, positioning of a therapeutic device and other uses. Also provided are devices and systems that can be used in practicing the described methods including but not limited to trajectory guides and adjustable targeting systems, as well as non-transitory computer readable medium storing instructions that, when executed by a computing device, cause a computing device to perform steps of the described methods.Type: GrantFiled: August 29, 2017Date of Patent: April 12, 2022Assignees: The Regents of the University of California, Voyager Therapeutics, Inc.Inventors: Krystof S. Bankiewicz, Kathryn H. Rosenbluth, Adrian P. Kells
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Publication number: 20220096657Abstract: The invention provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.Type: ApplicationFiled: August 26, 2021Publication date: March 31, 2022Applicants: Voyager Therapeutics, Inc., Voyager Therapeutics, Inc.Inventors: Steven Paul, Wencheng Liu, Jinzhao Hou, Yanqun Shu
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Patent number: 11198873Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of modulatory polynucleotides.Type: GrantFiled: January 9, 2020Date of Patent: December 14, 2021Assignee: VOYAGER THERAPEUTICS, INC.Inventors: Jinzhao Hou, Mathieu E. Nonnenmacher, Pengcheng Zhou