Abstract: Provided herein formulations of capsaicin for delivery by nasal route and methods of using the formulations for the treatment of migraines and other severe headaches. The formulations described herein contain mucoadhesives to optimize the therapeutic effect of capsaicin by intranasal delivery.

Abstract: The present invention relates to the use of client and server software communicating with each other via the internet to create and maintain a multi-user role-playing game. The virtual world of the game is presented to each user by means of text and dimensional audio. The virtual world of the game is infinitely expandable and updateable, and the software reacts to user inputs to make the virtual world change according to user actions. New users may join an in-progress game at any time.

Abstract: An interactive multi-player computer hosted game employs an unstructured telecommunications link, such as the Internet, between a game server and a plurality of game clients. A game server, associated with a game driver, performs a performance monitoring function to determine an optimal bandwidth for each connection to a game client. Each information packet generated by the game driver is prioritized and queued for transmission in order of relevance for the game client. The game server then optimizes the transmission of information packets through the telecommunication network to the game client. Processed user input is received through the telecommunication network from the game client and transmitted to the game driver.

Abstract: One embodiment of the present invention relates to a computer game that is played over a computer network and is capable of accommodating a large number of players. When the game is play on the Internet, players are able to input moves and be apprised of the state of the game using the basic input/output functions of their Web browser. Consequently, the game can be played with substantially no other game related software, plug-ins or add-ons. Another embodiment of the invention relates to the management of a game data base so as to compensate for the lack of game resources that a newer player has relative to older players that are likely to possess significantly greater game resources. Further, the virtual space of the game is highly expandable and updatable. In another embodiment of the invention a game is provided that couples game playing and advertising via a game currency that an advertiser can provide to a player and which can be used by the player in playing the game.