Patents Assigned to Vsesojuzny Kardiologichesky Nauchny Tsentr
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Patent number: 4842854Abstract: An antianginal composition in the form of a plate is provided for treating ischemic heart disease and is comprised of a biologically soluble and resolvable film and an antianginal coronary vasodilating nitrate. This film is placed buccally on the gum or mouth mucosa for rapid arresting or prevention of angina pectoris attacks.The antianginal film is in the form of a plate, 0.1 to 1.5 mm thick, consisting of a biologically soluble and resolvable carrier. Preferably, the film is comprised of a homopolymer of acrylamide or vinylpyrrolidone, or a copolymer thereof with acrylate, containing from 99 to 70 percent by weight of acrylamide with vinylpyrrolidone and from 1 to 30 percent by weight of acrylate having a molecular mass from 50,000 to 1,000,000 and the active principle having antianginal action, the components being taken in the following proportions, in percent by weight:active substance having antianginal action: 3.0-30.0biologically soluble and resolvable carrier: 70.0-97.Type: GrantFiled: May 13, 1987Date of Patent: June 27, 1989Assignee: Vsesojuzny Kardiologichesky Nauchny Tsentr Akademii Meditsinskiki Nauk SSRInventors: Eduard A. Babaian, Galina A. Gerasimova, Anatoly B. Davydov, Rustam I. Utyamyshev, Gennady L. Khromov, Vladimir I. Metelitsa, Anatoly M. Vikhert, Konstantin L. Savvateev, Vladimir K. Piotrovsky, Elizaveta B. Novikova
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Patent number: 4698419Abstract: A novel hexapeptide having the following structure:Phe-Ala-Gly-Phe-Gly-Arg.The hexapeptide according to the present invention has a hepatoprotective effect.Type: GrantFiled: February 5, 1986Date of Patent: October 6, 1987Assignee: Vsesojuzny Kardiologichesky Nauchny Tsentr Akademii Meditsinskikh Nauk SSSRInventors: Evgeny I. Chazov, Vladimir N. Smirnov, Valentin A. Vinogradov, Vladimir M. Polonsky, Valentina A. Tischenko, Mikhail I. Titov, Zhanna D. Bespalova, Boris L. Pekelis
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Patent number: 4695622Abstract: A novel hexapeptide having the following structure:Tyr-Ala-Gly-Phe-Leu-Arg.The hexapeptide according to the present invention possesses an antipancreonecrotic activity.Type: GrantFiled: February 5, 1986Date of Patent: September 22, 1987Assignee: Vsesojuzny Kardiologichesky Nauchny Tsentr Akademii Meditsinskikh Nauk SSSRInventors: Evgeny I. Chazov, Vladimir N. Smirnov, Valentin A. Vinogradov, Mikhail I. Titov, Vladimir A. Penin, Alexandr K. Giorgadze, Galina P. Titova, Zhanna D. Bespalova, Boris L. Pekelis, Nikolai K. Permyakov, Sergei I. Emelyanov, Alexandr A. Dzhikia
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Patent number: 4446316Abstract: A method of preparing a polysaccharide derivative of fibrinolysin which comprises reacting fibrinolysin with dextran dialdehyde having a molecular mass of from 20,000 to 110,000 at a pH of from 8.0 to 9.5 and at a temperature within the range of from 5.degree. to 30.degree. C. with the formation of a covalent bond; the resulting fibrinolysin derivative is reduced with sodium borohydride and isolated.Type: GrantFiled: December 9, 1981Date of Patent: May 1, 1984Assignee: Vsesojuzny Kardiologichesky Nauchny TsentrInventors: Evgeny I. Chazov, Vladimir N. Smirnov, Vladimir P. Torchilin, Igor M. Tereshin, Boris V. Moskvichev, Grigory M. Grinberg, Agris Z. Skuya, Gersh I. Kleiner
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Patent number: 4257269Abstract: A method for producing a visible image of an object is disclosed in which a fermental plate is illuminated with ultrasonic waves and a latent image of the object is therefore produced therein which is developed using a solution of chromogenic substrates, comprising, for example, hydrogen peroxide and a water-soluble aromatic amine. An apparatus to practice the disclosed method comprises an ultrasonic generator to generate ultrasonic waves illuminating the object, a fermental plate to receive and convert the ultrasonic waves passed through the object to a visible image, and a tray filled with a developer to develop the latent image of the object in the fermental plate.Type: GrantFiled: July 20, 1978Date of Patent: March 24, 1981Assignee: Vsesojuzny Kardiologichesky Nauchny Tsentr Akademii Meditsinskikh Nauk SSSRInventors: Ilia V. Berezin, Viktor S. Goldmakher, Alexandr M. Klibanov, Karel Martinek, Alexandr A. Mishin, Gennady P. Samokhin, Vladimir N. Smirnov, Vladimir P. Torchilin, Evgeny I. Chazov