Patents Assigned to VSL Pharmaceuticals Inc.
  • Publication number: 20140140971
    Abstract: The invention relates to a composition which, depending on the user, may be taken as a nutritional, dietetic or strictly therapeutic preparation, comprising as its active substance alkaline sphingomyelinase which is capable of preventing or treating various pathological conditions including cancerous processes, inflammatory processes of the intestine, hypercholesterolaemia and infections with Helicobacter pylori.
    Type: Application
    Filed: January 27, 2014
    Publication date: May 22, 2014
    Applicant: VSL PHARMACEUTICALS INC.
    Inventor: Claudio DE SIMONE
  • Patent number: 8697051
    Abstract: The invention relates to a composition which, depending on the user, may be taken as a nutritional, dietetic or strictly therapeutic preparation, comprising as its active substance alkaline sphingomyelinase which is capable of preventing or treating various pathological conditions including cancerous processes, inflammatory processes of the intestine, hypercholesterolaemia and infections with Helicobacter pylori.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: April 15, 2014
    Assignee: VSL Pharmaceuticals Inc.
    Inventor: Claudio De Simone
  • Patent number: 7959911
    Abstract: Strains of bacteria characterized by exhibiting: (a) a 7?-dehydroxylase activity of less than 50%, and (b) a bile acid deconjugation activity of less than 50%, and descendants, mutants and derivatives thereof preserving activities (a) and (b); and a pharmaceutical composition using one or more of such strains and use of same for preventing and treating diseases associated with or caused by an altered metabolism of bile acids.
    Type: Grant
    Filed: June 18, 2002
    Date of Patent: June 14, 2011
    Assignee: VSL Pharmaceuticals Inc.
    Inventor: Claudio De Simone
  • Publication number: 20080131556
    Abstract: A mixture of at least 6 species of lactic acid bacteria and/or Bifidobacteria is disclosed for use in bakery and medical field. The preferred mixture comprises Streptococcus thermophilus, Bifidobacterium infantis, Bifidobacterium longum, Bifidobacterium breve, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus delbrueckii subsp. bulgaricus. Said mixture is useful for a sourdough, a leavening composition. Baked goods and other food products obtained therefrom are disclosed. These goods have low or no gluten content and are suitable for the integration of the diet of a subject suffering from celiac disease, for decreasing the risk of allergies due to wheat flour albumins and globulins, for the treatment of schizophrenic symptoms, in the preparation of products for enteric diet.
    Type: Application
    Filed: March 7, 2006
    Publication date: June 5, 2008
    Applicant: VSL PHARMACEUTICALS, INC.
    Inventors: Claudio De Simone, Franco Pirovano
  • Patent number: 7323317
    Abstract: An analytical fluorometric method and a kit for use in such method are disclosed for assessing the presence of alkaline sphingomyelinase (SMase) in the stool of a patient in need of such an assessment since alkaline SMase is a marker of serious pathological states, such as colon cancer.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: January 29, 2008
    Assignee: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Publication number: 20070253934
    Abstract: Describes a new strain of Streptococcus thermophilus ssp. salivarius (deposited on 4 Dec. 2001 at the DSMZ—Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, Germany, with accession No. DSM 14667) and edible compositions, drugs and veterinary products containing it. The use of the said strain is particularly effective in the prevention/treatment of hepatic steatosis (fatty liver) and in nonalcoholic hepatic steatosis.
    Type: Application
    Filed: November 27, 2006
    Publication date: November 1, 2007
    Applicant: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Publication number: 20070218132
    Abstract: The present invention relates to a pH test glove bearing a reporter substance indicating the possible presence of vaginal affection. such as infections, in particular bacterial vaginosis, or vaginitis. This glove is easy to use, accurate and safe for the woman using it.
    Type: Application
    Filed: December 23, 2004
    Publication date: September 20, 2007
    Applicants: ACTIAL FARMACEUTICA LDA., VSL PHARMACEUTICALS, INC.
    Inventor: Claudio De Simone
  • Publication number: 20070154974
    Abstract: An analytical fluorometric method and a kit for use in such method are disclosed for assessing the presence of alkaline sphingomyelinase (SMase) in the stool of a patient in need of such an assessment since alkaline SMase is a marker of serious pathological states, such as colon cancer.
    Type: Application
    Filed: March 1, 2007
    Publication date: July 5, 2007
    Applicant: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Patent number: 7223591
    Abstract: Describes a new strain of Streptococcus thermophilus ssp. salivarius (deposited on 4 Dec. 2001 at the DSMZ—Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, Germany, with accession No. DSM 14667) and edible compositions, drugs and veterinary products containing it. The use of the said strain is particularly effective in the prevention/treatment of hepatic steatosis (fatty liver) and in nonalcoholic hepatic steatosis.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: May 29, 2007
    Assignee: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Patent number: 7217416
    Abstract: The use of G class immunoglobulins, particularly immunoglobulins for intravenous use or for intramuscular use to produce a medicine for the local therapeutic treatment of dermatitis, particularly acne, contact dermatitis, atopic dermatitis, eczema and ichthyosis, psoriasis papulosquamous dermatopathies (seborrehic dermatitis, erythrodermia, etc.), as well as fungus, parasite, bacterium and virus infection dermatitis is disclosed. The pharmaceutical composition containing G class immunoglobulins suitable for topical application for the treatment of dermatitis is also disclosed.
    Type: Grant
    Filed: May 20, 2002
    Date of Patent: May 15, 2007
    Assignee: VSL Pharmaceuticals, Inc.
    Inventors: Claudio De Simone, Pietro Bruschi
  • Patent number: 7211410
    Abstract: An analytical fluorometric method and a kit for use in such method are disclosed for assessing the presence of alkaline sphingomyelinase (SMase) in the stool of a patient in need of such an assessment since alkaline SMase is a marker of serious pathological states, such as colon cancer.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: May 1, 2007
    Assignee: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Patent number: 7147847
    Abstract: Disclosed is the use of bacteria endowed with arginine deiminase to induce apoptosis and/or reduce an inflammatory reaction, and pharmaceutical or dietetic compositions containing such bacteria. Also disclosed is a strain of Lactobacillus brevis highly endowed with arginine deiminase.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: December 12, 2006
    Assignee: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Publication number: 20060141551
    Abstract: The use of an alkanoyl L-carnitine for preparing a medicament for treating the erectile dysfunction is described.
    Type: Application
    Filed: February 23, 2006
    Publication date: June 29, 2006
    Applicant: VSL Pharmaceuticals, Inc
    Inventor: Claudio De Simone
  • Patent number: 7052688
    Abstract: The disclosure is of a combination of lactic acid bacteria comprising: (a) a first component consisting of at least one strain of H2O2-producing lactic acid bacteria; and (b) a second component consisting of at least one strain of arginine-utilizing lactic acid bacteria. The disclosure is also of the use of this combination for making a food supplement, a hygiene product or a pharmaceutical preparation for the prevention and/or treatment of infections and inflammatory conditions caused by bacteria, viruses or fungi, especially in the mouth, vagina, urethra, nose, eyes and ears.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: May 30, 2006
    Assignee: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Publication number: 20060057132
    Abstract: The presence of a vaginal affection is determined in a subject using an identifiable indicator and, if the indication is positive, a gynecological composition comprising one or more Lactobacillus strains is administered locally in an amount effective to treat the vaginal affection. Also described are packages or kits including a probe or tool such as a glove bearing a reporter substance for indicating the presence of a vaginal infection packaged together with a gynecological composition for treating the vaginal infection, if it is found to be present.
    Type: Application
    Filed: November 9, 2005
    Publication date: March 16, 2006
    Applicant: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Patent number: RE39118
    Abstract: The use of sphingomyelinase to increase the levels of skin and mucosal ceramides, as well as dermatolgical and cosmetic compositions containing game which are suitable for topical application are disclosed.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: June 6, 2006
    Assignee: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Patent number: RE39585
    Abstract: This invention provides materials and procedures for the delivery of selected strains of bacteria and/or oxalate-degrading enzymes to the intestinal tracts of persons who are at increased risk for oxalate related disease because they have lost, or have inadequate concentrations of these bacteria. The administration of these bacteria and/or the relevant enzyme removes oxalate from the intestinal tract and thus reduces the amount of oxalate available for absorption and reduces the risk for oxalate related disease.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: April 24, 2007
    Assignee: VSL Pharmaceuticals, Inc.
    Inventor: Claudio DeSimone
  • Patent number: RE39876
    Abstract: Enteral compositions containing Streptococcus thermophilus, Bifidobacterium infantis and Bifidobacterium longum, each at a concentration equal to or greater than 1×1011 CFU per gram, are useful as adjuncts for enteral formulations and as oral nutritional supplements. The compositions can be administered before, during or at the end of an enteral formulation administration. The compositions can be administered separately or mixed with the enteral formulation. The compositions can also be employed at the end of the daily administration in order to prevent the colonization of the enteral tube by the other pathogens. The compositions can also be used as supplement to any liquid, creamy or pasty foodstuff. The present invention relates to a kit comprising two containers, one containing a foodstuff and the other containing the enteral composition consisting of Streptococcus thermophilus, Bifidobacterium infantis and Bifidobacterium longum.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: October 9, 2007
    Assignee: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone
  • Patent number: RE40457
    Abstract: Enteral compositions containing a mixture of live lactic bacteria consisting of Streptococcus thermophilus, Bifidobacterium longum and Bifidobacterium infantis, each at a concentration equal to or greater than 1×1011 CFU per gram, are useful as adjuncts for enteral formulations and as oral nutritional supplements. The compositions can be administered before, during or at the end of an enteral formulation administration. The compositions can be administered separately or mixed with the enteral formulation. The compositions can also be employed at the end of the daily administration in order to prevent the colonization of the enteral tube by the other pathogens. The compositions can also be used as supplement to any liquid, creamy or pasty foodstuff.
    Type: Grant
    Filed: June 3, 1997
    Date of Patent: August 12, 2008
    Assignee: VSL Pharmaceuticals, Inc.
    Inventors: Renata Maria Anna Cavaliere ved. Vesely, Claudio De Simone
  • Patent number: RE41276
    Abstract: Strains of bacteria characterized by exhibiting: (a) a 7?-dehydroxylase activity of less than 50%, and (b) bile acid deconjugation activity of less than 50%, and descendants, mutants and derivatives thereof preserving activities (a) and (b); and a pharmaceutical composition using one or more of such strains and use of same for preventing and treating diseases associated with or caused by an altered metabolism of bile acids.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: April 27, 2010
    Assignee: VSL Pharmaceuticals, Inc.
    Inventor: Claudio De Simone