Abstract: Compositions and methods of use are provided for intrabodies that bind and alter the effects of poly-glutamate protein aggregation in poly-glutamate associated diseases, such as in Huntington's disease. Intrabodies are provided that prevent poly-glutamate aggregation, gene dysregulation, and negative effects of Huntington's disease.
Type:
Grant
Filed:
February 20, 2018
Date of Patent:
July 27, 2021
Assignee:
Vybion, Inc.
Inventors:
Lee Alan Henderson, Irene Alexandra Amaro
Abstract: Compositions and methods of use are provided for intrabodies that bind and alter the effects of poly-glutamate protein aggregation in poly-glutamate associated diseases, such as in Huntington's disease. Intrabodies are provided that prevent poly-glutamate aggregation, gene dysregulation, and negative effects of Huntington's disease.
Type:
Grant
Filed:
June 4, 2015
Date of Patent:
April 3, 2018
Assignee:
Vybion, Inc.
Inventors:
Lee Alan Henderson, Irene Alexandra Amaro
Abstract: The invention provides methods for the PEGylation of an N-terminal cysteine of a polypeptide such that the thiol group of the cysteine is unreacted in the fmal PEGylated polypeptide. In one embodiment, the invention comprises a method of PEGylating a polypeptide having an N-terminal cysteine, the method comprising: contacting the polypeptide with a polyethylene glycol (PEG) derivative having a free aldehyde group in a reaction mixture under reducing conditions such that the N-terminal cysteine in the resultant PEGylated polypeptide has a free thiol group.
Abstract: A method for assaying a biological sample includes forming sensitized microcapsules filled with unique oligomarkers, capturing sensitized microcapsules in the presence of analytes, releasing oligomarkers from microcapsules and detecting and measuring oligomarkers to detect and quantify presence of analyte in biological sample. Using encapsulated oligomarkers provides for an amplified high sensitivity assay and using plurality of oligomarker types provides for a multiplexed assay.
Type:
Application
Filed:
September 12, 2011
Publication date:
January 5, 2012
Applicant:
VYBION, INC.
Inventors:
Leo B. KRIKSUNOV, Geoffrey WHEELOCK, Lee A. HENDERSON
Abstract: A method for assaying a biological sample includes forming sensitized microcapsules filled with unique oligomarkers, capturing sensitized microcapsules in the presence of analytes, releasing oligomarkers from microcapsules and detecting and measuring oligomarkers to detect and quantify presence of analyte in biological sample. Using encapsulated oligomarkers provides for an amplified high sensitivity assay and using plurality of oligomarker types provides for a multiplexed assay.
Type:
Grant
Filed:
August 30, 2005
Date of Patent:
October 4, 2011
Assignee:
Vybion, Inc.
Inventors:
Leo B Kriksunov, Geoffrey Wheelock, Lee A Henderson
Abstract: The invention relates to antibodies, including chimeric monoclonal antibodies, and fragments thereof, that bind to cocaine. The invention also relates to the use of these or any anti-cocaine antibodies, derivatives or variants in the prevention or treatment of cocaine-related disorders and in the amelioration of one or more symptoms associated with a cocaine-related disorder.
Type:
Application
Filed:
December 5, 2008
Publication date:
June 10, 2010
Applicant:
Vybion, Inc.
Inventors:
Lee A. Henderson, John D. Noti, Wallace R. Fish, Brian Miller