Abstract: The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or more moieties that include hydrophobic portions. In some embodiments, the disclosure provides small-molecule cytotoxins that are chemically modified with fatty acid-containing moieties. In some aspects, the disclosure provides compositions, such as pharmaceutical compositions, that include such modified small-molecule cytotoxins and a protein. In some embodiments, the protein is albumin or an albumin mimetic. Further, the disclosure provides various uses of these compounds and compositions.
Type:
Application
Filed:
March 22, 2017
Publication date:
January 4, 2018
Applicants:
The Regents of the University of California, Vybyl, Inc.
Inventors:
Cassandra E. Callmann, Matthew P. Thompson, Nathan C. Gianneschi, Clare L. M. LeGuyader, Paul A. Bertin
Abstract: The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or more moieties that include hydrophobic portions. In some embodiments, the disclosure provides small-molecule cytotoxins that are chemically modified with fatty acid-containing moieties. In some aspects, the disclosure provides compositions, such as pharmaceutical compositions, that include such modified small-molecule cytotoxins and a protein. In some embodiments, the protein is albumin or an albumin mimetic. Further, the disclosure provides various uses of these compounds and compositions.
Type:
Application
Filed:
September 21, 2016
Publication date:
March 23, 2017
Applicants:
The Regents of the University of California, Vybyl, Inc.
Inventors:
Cassandra E. Callmann, Matthew P. Thompson, Nathan C. Gianneschi, Clare L. M. LeGuyader, Paul A. Bertin