Patents Assigned to Vysis
  • Patent number: 8594944
    Abstract: A method and/or system for making determinations regarding samples from biologic sources. A computer implemented method and/or system can be used to automate parts of the analysis.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: November 26, 2013
    Assignees: Vysis, Inc., Metasystems GmbH
    Inventors: James R. Piper, Ian Poole, Thomas Richard Lörch
  • Patent number: 8043805
    Abstract: Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: October 25, 2011
    Assignee: Vysis, Inc.
    Inventors: Irina A. Sokolova, Steven A. Seelig, Larry E. Morrison, Walter King, Alicia Algeciras-Schimnich
  • Patent number: 7998670
    Abstract: Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset of cells obtained from the biological sample are described. A set of chromosomal probes and kits for detecting cancer that include sets of chromosomal probes, are also described.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: August 16, 2011
    Assignees: Mayo Foundation for Medical Education and Research, Vysis, Inc.
    Inventors: Kevin C. Halling, Robert B. Jenkins, Walter King, Irina A. Sokolova, Steven A. Seelig
  • Publication number: 20090269768
    Abstract: Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.
    Type: Application
    Filed: April 13, 2009
    Publication date: October 29, 2009
    Applicant: Vysis, Inc.
    Inventors: IRINA A. SOKOLOVA, STEVEN A. SEELIG, LARRY E. MORRISON, WALTER KING, ALICIA ALGECIRAS-SCHIMNICH
  • Patent number: 7232655
    Abstract: Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset of cells obtained from the biological sample are described. A set of chromosomal probes and kits for detecting cancer that include sets of chromosomal probes, are also described.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: June 19, 2007
    Assignees: Mayo Foundation for Medical Education and Research, Vysis, Inc.
    Inventors: Kevin C. Halling, Robert B. Jenkins, Walter King, Irina A. Sokolova, Steven A. Seelig
  • Patent number: 6841388
    Abstract: A method and system for diagnosing pathology, such as carcinoma, in a biological sample identifies presence of pathology based on the existence of an infrared markers in the extracellular material, rather than cells, in the biological sample. In the case of breast cancer diagnosis, an effective marker is a baseline slope of a 1280 cm?1 band in the infrared spectra of connective tissue, with normal biopsy samples exhibiting a positive slope and cancerous samples showing a relatively flat baseline. Infrared spectroscopy, both microscopic and macroscopic, may be used to identify a sample region containing extracellular material and to collect infrared absorbance data, from which the existence of the pathology marker is determined.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: January 11, 2005
    Assignees: Vysis, Inc., Procter & Gamble
    Inventors: Rina K. Dukor, Curtis A. Marcott
  • Publication number: 20030170703
    Abstract: A method and/or system for making determinations regarding samples from biologic sources. A computer implemented method and/or system can be used to automate parts of the analysis.
    Type: Application
    Filed: January 14, 2003
    Publication date: September 11, 2003
    Applicant: Vysis, Inc., a Corporation of the State of Delaware
    Inventors: James R. Piper, Ian Poole, Thomas Richard Lorch
  • Publication number: 20030124589
    Abstract: A method of obtaining a corrected image of a microarray includes acquiring an image of a microarray including a target spot, and processing the image to correct for background noise and chip misalignment. The method also includes analyzing the image to identify a target patch, edit debris, and correct for ratio bias; and detecting single copy number variation in the target spot using an objective statistical analysis that includes a t-value statistical analysis. The method provides statistically robust computational processes for accurately detecting genomic variation at the single copy level.
    Type: Application
    Filed: October 11, 2002
    Publication date: July 3, 2003
    Applicant: Vysis, Inc.
    Inventor: James R. Piper
  • Patent number: 6569626
    Abstract: Direct label probe compositions which stain DNA of a preselected single chromosome or region of a chromosome of a multi-chromosomal genome are provided that comprise mixed DNA segments which are covalently bound to fluorophore groups through linking groups. The mixed DNA segments are derived from the DNA present in the preselected chromosome or chromosome region. These probe compositions can be used concurrently or sequentially with other probe compositions.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: May 27, 2003
    Assignee: Vysis, Inc.
    Inventors: Michael L. Bittner, Larry E. Morrison, Mona S. Legator
  • Patent number: 6482589
    Abstract: Nucleic acids having approximately 10 to 250 nucleotides which are capable of hybridizing to rRNA and RDNA of mycoplasma etiological agents of nongonococcal urethritis, pelvic inflammatory disease, salpingiuis, and other infections due to mycoplasmas from the genital areas, Mycoplasma hominis, Mycoplasma genitalium, and Ureaplasma urealyticum.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: November 19, 2002
    Assignee: Vysis, Inc.
    Inventors: William G. Weisburg, Dale A. Pelletier
  • Publication number: 20020164810
    Abstract: A method and system for diagnosing pathology, such as carcinoma, in a biological sample identifies presence of pathology based on the existence of an infrared markers in the extracellular material, rather than cells, in the biological sample. In the case of breast cancer diagnosis, an effective marker is a baseline slope of a 1280 cm−1 band in the infrared spectra of connective tissue, with normal biopsy samples exhibiting a positive slope and cancerous samples showing a relatively flat baseline. Infrared spectroscopy, both microscopic and macroscopic, may be used to identify a sample region containing extracellular material and to collect infrared absorbance data, from which the existence of the pathology marker is determined.
    Type: Application
    Filed: November 28, 2001
    Publication date: November 7, 2002
    Applicant: Vysis
    Inventors: Rina K. Dukor, Curtis A. Marcott
  • Patent number: 6455260
    Abstract: Fluorescence-based assay methods for detecting biological analytes in a sample. The fluorescence background in these methods is significantly lower than in conventional assay methods. Also provided are methods of attaching nucleic acids to a metallic or metalloid surface.
    Type: Grant
    Filed: October 16, 2001
    Date of Patent: September 24, 2002
    Assignee: Vysis, Inc.
    Inventors: Uwe Richard Müller, Diping Che, Yijia Bao
  • Patent number: 6376188
    Abstract: Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset of cells obtained from the biological sample are described. A set of chromosomal probes and kits for detecting cancer that include sets of chromosomal probes, are also described.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: April 23, 2002
    Assignees: Mayo Foundation for Medical Education and Research, Vysis, Inc.
    Inventors: Kevin C. Halling, Robert B. Jenkins, Walter King, Irina A. Sokolova, Steven A. Seelig
  • Publication number: 20020034762
    Abstract: Fluorescence-based assay methods for detecting biological analytes in a sample. The fluorescence background in these methods is significantly lower than in conventional assay methods. Also provided are methods of attaching nucleic acids to a metallic or metalloid surface.
    Type: Application
    Filed: October 16, 2001
    Publication date: March 21, 2002
    Applicant: Vysis, Inc., a Delaware corporation
    Inventors: Uwe Richard Muller, Diping Che, Yijia Bao
  • Patent number: 6306587
    Abstract: Methods, apparatus and compositions are presented for ligating ligands together which bind to a common receptor. One embodiment includes polynucleotide probes having photoreactive functional groups. The probes are capable of assuming substantially contiguous reactive positions on a target polynucleotide placing the photoreactive group in juxtaposition. Activation of the photoreactive functional groups with radiant energy form a probe reaction product in which the probes are bound to each other.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: October 23, 2001
    Assignee: Vysis, Inc.
    Inventors: Garfield P. Royer, Larry E. Morrison, Kenneth A. Cruickshank
  • Patent number: 6306589
    Abstract: Fluorescence-based assay methods for detecting biological analytes in a sample. The fluorescence background in these methods is significantly lower than in conventional assay methods. Also provided are methods of attaching nucleic acids to a metallic or metalloid surface.
    Type: Grant
    Filed: May 27, 1998
    Date of Patent: October 23, 2001
    Assignee: Vysis, Inc.
    Inventors: Uwe Richard Müller, Diping Che, Yijia Bao
  • Patent number: 6277569
    Abstract: Direct label probe compositions which stain DNA of a preselected single chromosome or region of a chromosome of a multi-chromosomal genome are provided that comprise mixed DNA segments which are covalently bound to fluorophore groups through linking groups. The mixed DNA segments are derived from the DNA present in the preselected chromosome or chromosome region. These probe compositions can be used concurrently or sequentially with other probe compositions.
    Type: Grant
    Filed: July 6, 1998
    Date of Patent: August 21, 2001
    Assignee: Vysis, Inc.
    Inventors: Michael L. Bittner, Larry E. Morrison, Mona S. Legator
  • Patent number: 6268128
    Abstract: The invention is a method of detecting nucleic acids in a sample using oligonucleotide probes which are noncovalently bound to solid supports for rapid, sensitive, hybridization assays. The method involves coating the support surface with a polynucleotide and then hybridizing a specific capture probe for each analyte to the polynucleotide by way of a short tail of the complementary polynucleotide. The immobilized probes are used to capture nucleic acid targets out of complex specimens for nonisotopic detection without the need for prior cell culture or purification of the target nucleic acids. A panel of tests can be run on each specimen simultaneously, a format that conserves precious samples. The assay can be readily automated, and can be conveniently run in a manual fashion on large numbers of samples in two to three hours.
    Type: Grant
    Filed: June 22, 1992
    Date of Patent: July 31, 2001
    Assignee: Vysis, Inc.
    Inventors: Mark L. Collins, David V. Morrissey
  • Patent number: 6251601
    Abstract: The invention comprises a multi-color, comparative hybridization assay method using an array of nucleic acid target elements attached to a solid support for the simultaneous detection of both gene expression and chromosomal abnormalities in a tissue sample. The method of the invention employs a comparative hybridization of a tissue mRNA or cDNA sample labeled in a first fluorescent color, a tissue chromosomal DNA sample labeled in a second fluorescent color, and at least one reference nucleic acid labeled in a third fluorescent color, to the array. The fluorescent color presence and intensity at each of at least two target elements are detected and the fluorescent ratios (i) of the first and third colors and (ii) the second and third colors determined. Gene expression and chromosomal abnormalities are thus simultaneously detected.
    Type: Grant
    Filed: February 2, 1999
    Date of Patent: June 26, 2001
    Assignee: Vysis, Inc.
    Inventors: Yijia Bao, Diping Che, Wan-Liang Li, Uwe Richard Müller, Steven A. Seelig, Jufang Shi
  • Patent number: RE37891
    Abstract: A method of assay for target polynucleotides includes steps of isolating target polynucleotides from extraneous non-target polynucleotides, debris, and impurities and amplifying the target polynucleotide.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: October 22, 2002
    Assignee: Vysis, Inc.
    Inventors: Mark L. Collins, Donald N. Halbert, Walter King, Jonathan M. Lawrie