Patents Assigned to Vysoka Skola Chemicko-Technologicka V Praze
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Publication number: 20230074000Abstract: A device for preparation of liquid marbles that has a belt conveyor for carrying a layer of solid particles, the belt conveyor being provided, successively in the direction of movement of the belt with at least one solids dispenser with a reservoir for solid particles, at least one liquid dispenser with a reservoir for liquid, and a separator for separating the prepared liquid marbles from solid particles, is disclosed.Type: ApplicationFiled: February 17, 2021Publication date: March 9, 2023Applicant: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZEInventors: Ondrej RYCHECKY, Frantisek STEPANEK, Martin KROV
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Patent number: 11492327Abstract: New aminooxylipids of general formula I, wherein n1=5-30 and X is polymethylene linker of the general formula II where n2=2-10, or X is polyethylene glycol linker of the general formula III, wherein n3=1-14 are provided. A method of preparation of the aminooxylipids of general formula I characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH3)3C—O—(C?O)—HN—(CH2)n—NH2, n=2-13}, or N-tert-butoxycarbonyl-polyethyleglycoldiamine {(CH3)3C—O—(C?O)—HN—(CH2)2—[O—(CH2)]n—O—(CH2)2NH2, n=1-14} with in position C(2) symmetrically branched fatty acids of general formula IV, wherein n1=5-30, in the presence of condensation reagent, or from acid of general formula IV derived acylchloride of general formula V wherein n1=5-30, produces N-Boc-aminolipids of general formula VI, wherein n1=5-30 a X is polymethylene linker of the general formula II or X is polyethylene glycol linker of the general formula III.Type: GrantFiled: November 2, 2017Date of Patent: November 8, 2022Assignees: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE, VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V. V. I., APIGENEX S.R.O.Inventors: Miroslav Ledvina, Roman Effenberg, Jaroslav Turanek, Elissa Bartheldyova, Ladislav Droz, Josef Masek, Frantisek Hubatka
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Publication number: 20220192985Abstract: A formulation of composites having yeast-derived beta glucan particles (GPs) and water-insoluble or poorly-water-soluble low-molecular-weight compounds, such as medicaments or food supplements is disclosed. The composites can exhibit different crystallinity degrees depending on the formulation and, consequently, dissolution kinetics can be controlled. Yeast-derived beta glucan particles are used as carriers for the encapsulation and amorphization of insoluble or poorly water-soluble low-molecular-weight compounds; amorphous formulations exhibiting faster dissolution rates, and consequently, enhanced oral bioavailability. A method of preparation of the composites by spray drying is also disclosed.Type: ApplicationFiled: April 2, 2020Publication date: June 23, 2022Applicant: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZEInventors: Gabriela RUPHUY CHAN, Frantisek STEPANEK, Jaroslav HANUS, Petra SALAMUNOVA, Ivan SALON
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Publication number: 20210292275Abstract: New aminooxylipids of general formula I, wherein n1=5-30 and X is polymethylene linker of the general formula II where n2=2-10, or X is polyethylene glycol linker of the general formula III, wherein n3=1-14 are provided. A method of preparation of the aminooxylipids of general formula I characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH3)3C—O—(C?O)—HN—(CH2)n—NH2, n=2-13}, or N-tert-butoxycarbonyl-polyethyleglycoldiamine {(CH3)3C—O—(C?O)—HN—(CH2)2—[O—(CH2)]n—O—(CH2)2NH2, n=1-14} with in position C(2) symmetrically branched fatty acids of general formula IV, wherein n1=5-30, in the presence of condensation reagent, or from acid of general formula IV derived acylchloride of general formula V wherein n1=5-30, produces N-Boc-aminolipids of general formula VI, wherein n1=5-30 a X is polymethylene linker of the general formula II or X is polyethylene glycol linker of the general formula III.Type: ApplicationFiled: November 2, 2017Publication date: September 23, 2021Applicants: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE, VYZKUMNY USTAV VETERINARNIHO LEKARSTVI, V.V.I., APIGENEX S.R.O.Inventors: Mirolav LEDVINA, Roman EFFENBERG, Jaroslav TURANEK, Elissa BARTHELDYOVA, Ladislav DROZ, Josef MASEK, Frantisek HUBATKA
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Patent number: 9932339Abstract: Helquat derivatives of general formula I, in which substituents R1 and R2 are independently selected from a group comprising H and C1 to C4 alkyl, up to three of S1,2, S1?,2?, S3,4 and S3?,4? are present, each of S1,2, S1?,2?, S3,4 and S3?,4? independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms, preferably hydrocarbon chain having 4 carbon atoms, and one to four atoms selected from the carbon atoms with the descriptor 2, 4, 2?, and 4? are substituted with a substituent R3 of general formula II, wherein R4 is substituted or unsubstituted heteroaryl, T1 and T2 are independent linkers that bridge atoms N5 with C8 and N5? with C8?, wherein T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms, preferably 2 or 3 carbon atoms; and anions (X1)? and (X2)? independently represent anions of pharmaceutically acceptable salts.Type: GrantFiled: May 26, 2015Date of Patent: April 3, 2018Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZEInventors: Filip Teply, Miroslav Hajek, Erika Kuzmova, Jaroslav Kozak, Veronika Komarkova, Pavla Hubalkova, Paul Eduardo Reyes-Gutierrez, Michael Jirasek, Manoj R. Sonawane, Vishwas D. Joshi, Lukas Severa, Jana Novotna
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Publication number: 20170096433Abstract: Helquat derivatives of general formula I, in which substituents R1 and R2 are independently selected from a group comprising H and C1 to C4 alkyl, up to three of S1,2, S1?,2?, S3,4 and S3?,4? are present, each of S1,2, S1?,2?, S3,4 and S3?,4? independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms, preferably hydrocarbon chain having 4 carbon atoms, and one to four atoms selected from the carbon atoms with the descriptor 2, 4, 2?, and 4? are substituted with a substituent R3 of general formula II, wherein R4 is substituted or unsubstituted heteroaryl, T1 and T2 are independent linkers that bridge atoms N5 with C8 and N5? with C8?, wherein T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms, preferably 2 or 3 carbon atoms; and anions (X1)? and (X2)? independently represent anions of pharmaceutically acceptable salts.Type: ApplicationFiled: May 26, 2015Publication date: April 6, 2017Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZEInventors: Filip TEPLY, Miroslav HAJEK, Erika KUZMOVA, Jaroslav KOZAK, Veronika KOMARKOVA, Pavla HUBALKOVA, Paul Eduardo REYES-GUTIERREZ, Michael JIRASEK, Manoj R. SONAWANE, Vishwas D. JOSHI, Lukas SEVERA, Jana NOVOTNA
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Patent number: 8013190Abstract: The present invention provides novel HIV protease inhibitors containing substituted borane, carborane or metallacarborane clusters with 6 to 12 boron atoms in each cluster. The charge of each borane, carborane or metallacarborane cluster is 0, ?1 or ?2. The number of borane, carborane or metallacarborane clusters in the inhibitor molecule is 1 to 9, and the carborane clusters in metallacarborane inhibitors are coordinated to transition metal atom, selected from the group containing cobalt, iron, nickel and ruthenium. In the cluster, heteroatoms can be present, such as nitrogen, phosphorus, silicon, germanium, tin and sulphur. The present invention covers pharmaceutical compositions containing these inhibitors and their use, both in vitro and in vivo. They are characterized by high effectiveness and stability.Type: GrantFiled: January 27, 2005Date of Patent: September 6, 2011Assignees: Vysoka Skola Chemicko-Technologicka V Praze, Ustav Organicke Chemie A Biochemie AV CZ, Ustav Anorganicke Chemie AV CZ, Department of Virology, University of HeidelbergInventors: Vladimír Král, Petr Cigler, Jan Konvalinka, Milan Kozísek, Jana Prejdová, Bohumír Grüner, Jaromír Plesek, Martin Lepsík, Jana Pokorná, Hans-Georg Kräusslich, Jochen Bodem
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Publication number: 20090012044Abstract: The present invention provides novel HIV protease inhibitors containing substituted borane, carborane or metallacarborane clusters with 6 to 12 boron atoms in each cluster. The charge of each borane, carborane or metallacarborane cluster is 0, ?1 or ?2. The number of borane, carborane or metallacarborane clusters in the inhibitor molecule is 1 to 9, and the carborane clusters in metallacarborane inhibitors are coordinated to transition metal atom, selected from the group containing cobalt, iron, nickel and ruthenium. In the cluster, heteroatoms can be present, such as nitrogen, phosphorus, silicon, germanium, tin and sulphur. The present invention covers pharmaceutical compositions containing these inhibitors and their use, both in vitro and in vivo. They are characterized by high effectiveness and stability.Type: ApplicationFiled: January 27, 2005Publication date: January 8, 2009Applicants: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE, USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CZ, USTAV ANORGANICKE CHEMIE AV CZ, DEPARTMENT OF VIROLOGY, UNIVERSITY OF HEIDELBERGInventors: Vladimir Kral, Petr Cigler, Jan Konvalinka, Milan Kozisek, Jana Prejdova, Bohumir Gruner, Jaromir Plesek, Martin Lepsik, Jana Pokorna, Hans-Georg Krausslich, Jochen Bodem