Abstract: Deployment systems and methods are provided herein for percutaneous transcatheter deployment of medical devices. A medical device deployment system includes a body member and a body locking member that is configured to cooperatively engage along a portion of the body member such that the body member is releasably coupleable to a medical device.

Abstract: A flexible, passive pressure sensor includes three LC tank circuits. The first LC tank circuit is a pressure sensing LC tank circuit, having a capacitance that varies in response to changes in environmental pressure. The second and third LC tank circuits are reference LC tank circuits, having capacitances that are relatively constant over changes in environmental pressure. A measurement tool measures the resonant frequencies of the three LC tank circuits and then computes a pressure measurement that accounts for changes in resonant frequencies in the LC tank circuits due to environmental effects and deforming.

Abstract: An improved medical device reduces the loss of longitudinal length during expansion of a stent-graft from a compressed state to an expanded state. For example, the stent-graft is placed over a cover that provides resistance to expansion of the balloon during inflation, which reduces longitudinal compressing forces exerted on the stent-graft.

Abstract: A storage bag configured to contain or that contains at least one therapeutic compound such as a viral vector and non-viral vector is provided. In one embodiment, the storage bag contains a viral vector and/or a non-viral vector containing genetic material. The storage bag has two edges and two ends including a first face and a second face integrally joined at the two edges of the bag and defining an inner surface and an outer surface forming the bag; the inner surface including a higher melting polymer, and the outer surface including a lower melting polymer; a joint at one of the ends; a discrete composite sheet having a first side including a higher melting polymer and a second side including a lower melting polymer folded over the joint with the first side including a lower melting polymer engaging the joint to form a lap seam over the joint.

Abstract: Devices for collecting and analyzing a fluid sample comprise a fluid-collecting porous material comprising at least one hydrophilic porous layer and one or more sensors adapted to provide a response to the presence of an analyte. The detectors are useful for collecting and analyzing a very small volume of sample and may include features that facilitate and direct flow of the sample through porous material.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include an implantable medical device and a constraining line conduit arranged around a circumference of the implantable medical device. The apparatuses, systems, and methods may also include a constraining line arranged through the constraining line conduit.

Abstract: The present disclosure describes a medical device assembly comprising an expandable medical device wrapped with an improved constraining sleeve. The sleeve in accordance with various embodiments of the present disclosure is thin walled and translucent, having reduced edge sharpness. The sleeve in accordance with the present disclosure exhibits resistance to ripping and delamination. Various embodiments of the present disclosure provide methods of making sheet material usable for constraining sleeves from flattened film tubes. Methods for making improved constraining sleeves and medical device assemblies that comprise an improved constraining sleeve are also disclosed herein.

Abstract: An implantable medical device for connecting tissue layers, such as connecting tubular tissues to create an anastomosis, includes a single elongate member and a covering material. The devices provided may also be used for other purposes including, but not limited to, partially or fully occluding openings in tissue, temporarily or permanently holding generally planar layers of tissue together, aneurysm repair, and the like.

Abstract: A tapered implantable device includes an ePTFE tubular member having a tapered length portion. The tapered length portion provides rapid recovery properties. The tapered length portion can feature a microstructure that includes a multiplicity of bent fibrils.

Abstract: A carrying device includes a retractable support system for equipment carried in the hand. In some embodiments, the carrying device comprises a frame assembly for transporting larger loads and optimizing the weight distribution thereof. In some embodiments, the carrying device includes a support shelf. In some embodiments, the carrying device includes an expandable volume.

Abstract: Methods and compositions for making fuel cell components are described. In one embodiment, the method comprises providing a substrate, and forming or adhering an electrode on the substrate, wherein the forming includes depositing an aqueous mixture comprising water, a water-insoluble component, a catalyst, and an ionomer. The water-insoluble component comprises a water-insoluble alcohol, a water-insoluble carboxylic acid, or a combination thereof. The use of such water-insoluble components results in a stable liquid medium with reduced reticulation upon drying, reduced dissolution of the substrate, and reduced penetration of the pores of the substrate.

Abstract: The present invention is directed to an affinity chromatography device that has a normal flow and which separates a targeted protein from aqueous mixtures. The chromatography device includes a housing containing therein a spiral wound membrane assembly that includes at least one inner intermediate material that forms an outer flow channel, at least one polymer membrane that contains therein inorganic particles, and at least one outer intermediate material that forms an inner flow channel sequentially positioned around a central core having a solid outer wall. An aqueous mixture is passed through the outer flow channel, through the polymer membrane where the targeted protein is removed, and then through an inner flow channel. The affinity chromatography device further includes an inlet flow distributor containing an inlet and an outlet flow distributer containing an outlet. Additionally, the chromatography device has a dimensionless resistance parameter that is less than 0.08.

Abstract: Water impermeable, air permeable membrane assemblies are described herein. In some embodiments, the assemblies include a polymer membrane and at least one support structure. Certain assemblies are configured to provide an acoustic impedance having phase angle of +45 degrees to ?45 over a frequency range of 50 to 20,000 Hz.

Abstract: A diametrically adjustable endoprosthesis includes a controlled expansion element extending along at least a portion of a graft and is supported by a stent. The controlled expansion element diametrically constrains and limits expansion of the endoprosthesis. Upon deployment from a smaller, delivery configuration, the endoprosthesis can expand to the initial diameter set by the controlled expansion element. Thereafter, the endoprosthesis can be further diametrically expanded (e.g., using balloon dilation) by mechanically altering the controlled expansion element.

Abstract: The present disclosure comprises devices, systems, and methods having an inverted sheath configured to cover, and in some instances constrain, a medical device and to retract through eversion, thus enabling the deployment of medical device at the treatment site. A constraining sheath can evert hydraulically. A constraining sheath can be configured to neck down a medical device to achieve a lower delivery profile. Furthermore, a constraining sheath can comprise a balloon to expand or positionally or structurally adjust a medical device.

Abstract: The present disclosure describes implantable medical devices comprising covers, such as a balloon cover. Such devices can comprise a first layer of a porous polymeric material, such as ePTFE, surrounded by layers of a porous polymeric material having an imbibed elastomer, such as polyurethane. The cover can be used to assist in deployment of an expandable implant, such as a stent-graft, within the body of the patient.

Abstract: A catalytic membrane composite that includes porous supported catalyst particles durably enmeshed in a porous fibrillated polymer membrane is provided. The porous fibrillated polymer membrane may be manipulated to take the form of a tube, disc, or diced tape and used in multiphase reaction systems. The supported catalyst particles are composed of at least one finely divided metal catalyst dispersed on a porous support substrate. High catalytic activity is gained by the effective fine dispersion of the finely divided metal catalyst such that the metal catalyst covers the support substrate and/or is interspersed in the pores of the support substrate. In some embodiments, the catalytic membrane composite may be introduced to a stirred tank autoclave reactor system, a continuous flow reactor system, or a Parr Shaker reaction system and used to effect the catalytic reaction.

Abstract: A catheter system (110) for removal of occlusive material in a body lumen. The catheter system (110) includes a catheter body (10), extending between a distal end (20) and a proximal end (22) and having a proximal portion (29) and a distal portion (28). The catheter body (10) includes a filtration section (30A) having filter media (32) configured to permit blood to pass through the lumen of the catheter body (10) and inhibiting occlusive material from passing out of the catheter body (10). The catheter system (110) also includes a control handle (120) coupled to the proximal portion (29) of the catheter body (10) and a cutter assembly (12) having a drive mechanism (40) operatively coupled to the control handle (120). The cutter assembly (12) includes a drive mechanism (40) and a conveyor (44) coupled to the drive mechanism (40) and rotatable with the drive mechanism (40) to convey occlusive material proximally within the catheter body (10) and through the filtration section (30A).

Abstract: Medical device delivery systems and methods are disclosed. In various examples, the medical device delivery system (1000) includes an elongate element (1100) including an olive (1200). The olive (1200) includes an opening that exposes a lockwire (1300) extending through a lumen of the olive (1200) such that a linking element (1500) can be coupled to the portion of the lockwire (1300) exposed by the opening, wherein the linking element (1500) provides a coupling to a medical device (1400).

Abstract: A thrombus treatment device includes a support wire, a body frame portion that is disposed about an axis defined by the support wire, one or more tethers that each have a first end and a second end, and a filter element extending from the body frame portion. Each of the one or more tethers is attached at its first end to the body frame portion, and at its second end to a collar that couples the second end of each of the multiple tethers to the support wire. When the collar is positioned substantially within a region interior of the body frame portion, a rotational actuation of the support wire causes a swiveling motion of the one or more tethers.