Abstract: Active compounds useful for inhibiting fatty acid synthase in a subject in need thereof are described. The active compounds are, in general, a 5-mercapto-1H-Indazole-4,7-dione or an analog thereof. The compounds are useful for treating subjects afflicted with, cancer, obesity, diabetes, a viral infection, a bacterial infection, a fungal infection, or a protozoal infection.
Type:
Application
Filed:
November 7, 2011
Publication date:
December 26, 2013
Applicant:
Waake Forest University Health Sciences
Inventors:
Steven J. Kridel, W. Todd Lowther, Herman W. Odens, Jeffrey D. Schmitt