Abstract: Ether lipid nucleoli covalent conjugates and derivatives thereof are disclosed, along with pharmaceutical compositions containing the same and methods of using the same to combat HIV-1 infections. Illustrative are 3'-Azido-3'-deoxythmidine-5'-monophosphate-D,L-3-octadecanamido-2-ethoxypr opane and 3'-Azido-3'-deoxythymidine-5'-butyrate-.gamma.-N,N,N-trimethyl -ammonium-.beta.-(1-phospho-2-ethoxy-3-hexadecyloxypropane).

Abstract: This invention provides a method of lowering cholesterol and blood lipid levels, preventing hypercholesterolemia, hyperlipidemia, cardiovascular disease, atherosclerosis, and peripheral vascular disease comprising administering an effective amount of 17.alpha.-dihydroequilenin or a mammalian metabolic conjugate thereof to a mammal in need thereof.

Abstract: Disclosed is a method and apparatus for gel electrophoresis which simultaneously employs two or more electric fields in a single gel. According to this invention, which is defined as Multiple-Zone Pulsed-Field Gel Electrophoresis (MZPFGE), the electric field is set to different values in two or more spatially distinct regions of the gel. The difference in values may be related to time dependence, field amplitude or both.

Abstract: A syringe apparatus is provided having a first control syringe with a hypodermic needle for injecting medication into a patient. A three-way stopcock interconnects the first syringe with the hypodermic needle and also interconnects the first syringe with a second reservoir syringe. A handle lever on the stopcock may be positioned to provide a first fluid flow path between the first syringe and the hypodermic needle to permit injection of medication into the patient. The handle lever of the stopcock may alternatively be positioned to provide a second fluid flow path to permit the first syringe to be refilled with medication from the second reservoir syringe for subsequent injection into the patient. The refilling of the first syringe from the reservoir syringe may be effected without removal of the needle from the patient and without disassembly of the first syringe.

Abstract: A self-calibrating tomosynthetic x-ray system is provided. A calibrated device for recording radiographic images of a selected object irradiated by a source of radiation includes a first radiolucent radiographic recording medium in the form of a CCD device for recording a first projected radiographic image of the selected object. A second radiographic recording medium in the form of a CCD device is supported in fixed generally parallel position relative to the first radiographic recording medium to permit radiation from the source to pass through the first radiographic recording medium and to impinge upon the second radiographic recording medium for recording a second projected radiographic image of the selected object. A radiopaque fiducial reference in the form of a grid is supported in fixed position generally between the first and second radiographic recording mediums to permit a projected image of the radiopaque fiducial reference to be recorded on the second radiographic recording medium.

Abstract: A method of combating mortality in a cell or tissue under stress is disclosed. The method comprises contacting hsp70 to the cell or tissue in an amount effective to enhance the survival of that cell or tissue. The method may be employed in the combating of atherosclerosis, restenosis after angioplasty, and nerve damage in human or animal subjects in need of such treatment. A pharmaceutical composition comprising a therapeutically effective amount of hsp70 in a pharmaceutically acceptable formulation is also disclosed.

Abstract: Preparation of biologically active tropane derivatives of novel configurations. The compounds are prepared by decomposing vinyldiazomethanes in the presence of pyrroles to provide a bicyclic ring containing the basic tropane ring system which is then reacted with an aryl Grignard reagent in the presence of a copper (I) or (II) salt to provide 3-aryl-tropane derivatives.

Abstract: Novel tropane ring system compounds useful for treatment of neurological disorders and for synthetic starting materials for production of cocaine analogs.

Abstract: Preparation of biologically active tropane derivatives of novel configurations. The compounds are prepared by decomposing vinyldiazomethanes in the presence of pyrroles to provide a bicyclic ring containing the basic tropane ring system which is then reacted with an aryl Grignard reagent in the presence of a copper (I) or (II) salt to provide 3-aryltropane derivatives.

Abstract: Patients suffering from neurodegenerative diseases are treated by administering an effective amount of a ferruginine compound or a anhydroecgonine compound.

Abstract: A panoramic dental radiography system projects multiple vertical, fan-shaped radiation beams through a subject's teeth and onto multiple detectors, with each fan-shaped beam avoiding the subject's spine. The radiographic source and radiographic detectors are rotated about a vertical axis, so that the detected radiation may be tomographically processed to produce a panoramic image of the teeth. The multiple vertical fan-shaped radiation beams are projected on either side of the spine, to reduce the radiographic dosage to the spine and to prevent the spine from blurring the panoramic radiograph. The resulting multiple projections can be tomosynthetically processed to produce a three-dimensional image of tissues of diagnostic interest, free of image artifacts produced by irradiation of the spine.

Abstract: This invention relates to a method of increasing cranial arterioles in warm-blooded animals comprising administering an effective amount of the compound having the formula 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-pyridine-3-.beta.-methoxyethyl ester)-5-(isopropyl ester), to said animals to achieve vessel proliferation.

Abstract: Two substantially purified larval T. solium antigens found circulating in the cerebrospinal fluid of patients infected with T. solium, having molecular weights of 190 KD and 230 KD, are disclosed. These antigens, alone or in combination, may be used to diagnose or to follow the course of neurocysticercosis, caused by T. solium infection.

Abstract: A method of delaying flowering in plants which control their flowering by producing a flowering inhibiting regulator on a seasonal basis is provided. In the method of the invention, a flowering inhibiting amount of the regulator is applied to the plant about the time in the growth cycle of the plant when the regulator is no longer produced by the plant. As a result, the duration of the inhibitory effect on the plant is prolonged. Bis (2-ethylhexyl) hexane dioate (BEHD) is disclosed as such a regulator. Also disclosed is a family of diesters of dicarboxylic acids having flowering inhibiting activity, other methods of treating plants with these compounds, and a new method of identifying flowering regulators.

Abstract: Immunological methods are disclosed for diagnosing active human neurocysticercosis, including a serum test and a cerebrospinal fluid test. The serum test involves detecting an antibody in serum which recognizes at least one of three particular antigens isolated from Taenia solium larvae. The cerebrospinal fluid test involves detecting an antigen or antigens of larval origin, preferably by an ELISA technique.

Abstract: A mammography cape which permits the selective exposure of a breast by a subject during a mammography procedure or the like, while otherwise preventing unwanted body exposure, is disclosed. The cape is formed of drapable sheet material having a neck opening formed in the center thereof. The cape has a front and back portion of generally equal dimensions which are connected together only along a transverse center line. Both the front and back portions of the cape have distally spaced draping panels on opposite sides, the front and back draping panels cooperating together to conceal the upper torso of a wearer on both sides of the cape.

Abstract: Lysophospholipids are used to induce diuresis in a subject by administering them in a dose effective to increase the renal excretion of sodium. Exemplary compounds useful in this method include steroyl-lysophosphatidylcholine and steroyl-lysophosphatidylethanolamine.

Abstract: Immunological methods are disclosed for diagnosing active human neurocysticercosis, including a serum test and a cerebrospinal fluid test. The serum test involves detecting an antibody in serum which recognizes at least one of three particular antigens isolated from Taenia solium larvae. The cerebrospinal fluid test involves detecting an antigen or antigens of larval origin, preferably by an ELISA technique.

Abstract: A method and apparatus for the bolus administration of a gas such as a radioactive gas includes a face mask defining a closed space into which a straw-like administration tube extends sufficiently to permit a patient wearing the face mask to suck on the tube. The radioactive gas is introduced through the administration tube and exhaled into the face mask.

Abstract: Assays and reagents for the direct determination of blood factors, as well as complementary methods and reagents for determining such blood factors and haptens, antigens and receptors. The methods involve clot formation due to thrombin activated fibrin formation from insolubilized fibrogen and labeled solubilized fibrogen. Insolubilized label can be determined prior to or after clot formation.