Abstract: An enclosed satellite antenna system can include a generally rigid enclosure defining a volume that is configured to enable both manual transportability of the satellite antenna system and automated operation of the satellite antenna system without a substantial change in the volume of the enclosure or manual repositioning of the satellite antenna system. The enclosure can have disposed therein a satellite dish, a feedhorn configured to collect incoming signals concentrated by the satellite dish, and a low noise block converter configured to receive incoming signals from the feedhorn, amplify and convert the incoming signals to received signals, and transmit the received signals to at least one receiver. A motorized elevation dravie system can be configured to selectively adjust an elevation of the satellite dish and a motorized azimuth drive system can be configured to selectively rotate the satellite dish.
Abstract: The present invention involves a rapid synthesis of .sup.18 F-FMISO and analogs thereof. New precursors such as 1-(2'-nitro-1'-imidazolyl)-2-0-acetyl-3-0-tosylpropanol, glycerol-1,3-ditosylate-2-0-acetylate, 1-(2'-nitro-1'-imidazolyl)-2,3-0-diacetylate, are also important aspects of the invention.A further aspect of the invention is the development of a hydrophilic PET ligand to image tumor hypoxia. Erythrotosyl analogue of 2-nitroimidazone (Ts-ETNIM) was prepared from a mixture of 2-nitromidazole, ditosylthreitol and cesium carbonate at 60.degree. C. for 1 hr. Ts-ETNIM was isolated at 70% yield. ?.sup.18 F!fluoroerythronitroimidazole (FETNIM) when prepared from Ts-ETNIM and K.sup.18 F/kryptofix.RTM.. The yield for ?.sup.18 F!FETNIM was 26-30% (60 min, decay corrected). Results of biodistribution and PET studies indicate that ?.sup.18 F!FETNIM has the potential to detect tumor hypoxia and is indicated to be less neurotoxic.
Type:
Grant
Filed:
April 4, 1996
Date of Patent:
March 17, 1998
Assignee:
Wallace Technologies
Inventors:
Sidney Wallace, David J. Yang, Abdallah Cherif