Abstract: The crystal structures of catalytic domain of HPTPbeta, both ligand-bound and ligand-free are described. These structures are useful in computer aided drug design for identifying compounds that bind or activate HPTPbeta and thereby modulate angiogenesis mediated disorders or diseases.
Type:
Grant
Filed:
March 23, 2009
Date of Patent:
August 3, 2010
Assignee:
Warner Chilcott, LLC
Inventors:
Artem Gennady Evdokimov, Matthew Eugene Pokross