Abstract: Non-C2-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C2-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.

Abstract: Described are new crystalline anhydrous forms of gabapentin formed from gabapentin monohydrate. The new crystalline forms provide advantages in the manufacture of the therapeutic agent.

Abstract: Compounds of formula I: wherein X, Y, B, E, J, K, L, Z, and R9-R12 have any of the meanings described herein, their pharmaceutically acceptable salts, lower blood glucose levels and are useful for treating diseases in mammals such as Non-Insulin Dependent Diabetes Mellitus. Also disclosed are pharmaceutical compositions, processes for preparing compounds of formula (I) and intermediates useful for preparing compounds of formula I.

Abstract: A replacement cartridge container is provided that includes a tub and a selectively removable lid. The tub includes a base panel attached to a side panel. The base panel and the side panel each have an interior surface and an exterior surface. A cavity is formed contiguous with the interior surfaces of the base panel and the side panel. The selectively removable lid attaches to the tub and forms a seal with the tub.

Abstract: The invention relates to subtype-selective NMDA receptor ligands and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neuro-degenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, Parkinson's disease, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.

Abstract: Shaving systems having a first support, at least one, and preferably a plurality, of resilient supports, and a plurality of skin-engaging elements movably arranged in spaced relation and supported by the resilient support. The resilient supports normally maintain the movable skin-engaging elements, e.g. blades, guards, and/or cap member, in spaced relation such that the movable, skin-engaging elements are spaced by a first distance, relative to each other, when the skin-engaging elements are in a normal, unbiased position. In one embodiment, when one or more of the skin-engaging elements is acted upon by forces normally encountered during shaving, the resilient supports yield in order to move each of the blades and the cap into a more aggressive position.

Abstract: The invention concerns an apparatus for the manufacture of films, in particular thin or very thin films, with a rotating roller with which a plastically deformable film preferably supplied by a slot extruder is conveyed and stretched, wherein between the roller and a metal belt arranged parallel and at a short distance from the roller is applied a voltage by which the film supplied is applied to the roller. In order to develop this apparatus in such a way that manufacture of films, in particular thin or very thin films, is possible with increased productivity and film quality, with the invention it is proposed that the metal belt comprises a sharp longitudinal edge which is arranged closest to the roller and directed onto it.

Abstract: A cap for a container having a screw threaded opening comprising an inner part (1) in the form of a screw threaded cap, an outer part (2), biased therefrom in a first, locking position, by means of resilient biasing means (3) located between the inner and outer parts, a projection (4) located on the inner part (1) and adapted to be received in an aperture (8) formed in the outer part (2), and a tamper-evident member (6) secured on the outer top surface of the outer part (2) such that it substantially covers the aperture (8), wherein on first removing the cap from the container the outer part (2) is moved into a second, unlocking position, against the biasing, the projection (4) being received in the aperture (8), and projecting therebeyond, such that at least a portion of the tamper-evident member (6) is ruptured.

Abstract: Methods for using substituted phenoxy-, 1-, and 2-naphthalenyloxy-, indenyl-, indolyl-, benzo[b] furanyl-, and benzo[b]thienylcarboxamides of 7,8-(substituted-diamino)-1-oxaspiro[4.5]decanes as agents for alleviating the symptoms of Parkinson's disease, dystonia, and other movement disorders are disclosed. Pharmaceutical compositions employing the compounds are also disclosed.

Abstract: Calcium lactate antibacterial complexes in parenteral dosage forms are provided that are relatively free from tissue irritation following injection, comprising a quinolone or naphthyridine.

Abstract: A method of treatment is provided for reducing or eliminating psychomotor addiction in mammalian subjects, employing as an active agent 3-phenoxypyridine or a pharmaceutically acceptable acid-addition salt thereof.

Abstract: An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien4-ol is converted in eight operations to the desired products, as well as an improved process for the preparation of (2R-trans) and trans-(.+-.)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetra hydro4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3carboxamide by a novel synthesis where 4-methyl-3-oxoN-phenylpentanamide is converted in eight operations to the desired product or alternatively 4-fluoro-.alpha.-[2methyl-1-oxopropyl]-.gamma.-oxo-N,.beta.-diphenylbenzen ebutaneamide is converted in one step to the desired product, and additionally, a process for preparing (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahy dro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1Hpyrrole-3-carboxamide from (R)-4-cyano-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]butanoic acid, as well as other valuable intermediates used in the processes.

Abstract: Compounds useful in treating hypercholesterolemia and atherosclerosis having the formula ##STR1## wherein X is oxygen or sulfur, Het is a monocyclic heterocyclic group having three hetero atoms selected from nitrogen, oxygen and sulfur, and R.sub.1, R.sub.2 and R.sub.3 are hydrogen, flourine, chlorine, bromine, a straight or branched alkyl group having from 1 to 6 carbon atoms, a straight or branched alkoxy group having from 1 to 6 carbon atoms, substituted or unsubstituted benzoyl, substituted or unsubstituted benzoyl, substituted or unsubstituted phenyl, amino or substituted amino or a carboxy group.

Abstract: Novel 4-oxy substituted phenoxyalkyl carboxylic acid, ester and alcohol derivatives are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of cholesterol and thus are useful in the treatment of hypercholesterolemia and atherosclerosis.

Abstract: The present invention relates to novel compounds, which are derivatives of ureas, thioureas, carbamates, sulfonylureas, sulfonamides, amides, and thioamides of 2-carboxyindoles as illustrated by the formula ##STR1## The invention also relates to methods for the preparation of the novel compounds, as well as to pharmaceutical compositions or methods of use for the novel compounds. More specifically, the compounds of the present invention are useful in the treatment of neurodegenerative disorders including cerebrovascular disorders as well as in the treatment of schizophrenia or epilepsy; and as analgesics and anxiolytics.

Abstract: The present invention is for selected novel compounds which are indoles substituted at the 3-position with [3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene as well as pharmaceutical compositions and methods of use thereof. These compounds have activity useful in treating allergies, arthritis, and inflammation.

Abstract: Substituted tetrahydropyridines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.

Abstract: Selected analogs of ninpecotic acid are the novel compounds of the present invention. The analogs are GABA uptake inhibitors for use to treat epilepsy and, thus, the invention is also pharmaceutical compositions and methods of use thereof.

Abstract: The present invention is novel diarylalkanoids having activity as lipoxygenase inhibitors, novel pharmaceutical compositions therefor, and novel methods of use in treating asthma, allergies, cardiovascular diseases, migrains, psoriasis and immunoinflammatory diseases for diarylalkanoids. The compounds of this invention are also useful as cytoprotective agents.