Abstract: This invention concerns novel renin-inhibitory peptides containing proline which are useful for treating renin associated hypertension and for treating hyperaldosteronism. Intermediates and processes for preparing both the intermediates and the novel peptides, pharmaceutical compositions, and methods of treatment are included. Also included is a method of diagnosis of renin-associated hypertension using the compounds of the invention.
Type:
Grant
Filed:
January 29, 1987
Date of Patent:
February 14, 1989
Assignee:
Warner-Lambert Copmany
Inventors:
James S. Kaltenbronn, Elizabeth A. Lunney, Ernest D. Nicolaides