Abstract: Novel forms of atorvastatin magnesium salt designated Form A, Form B, Form C, Form D, Form E, and Form F, pharmaceutical compositions containing such compounds, methods for their preparation and methods utilizing the compounds for treatment of hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia (BPH) and Alzheimer's disease are described.

Abstract: The invention provides 1,3,4-thiadiazoles and 1,3,4-oxadiazoles having the following Formula I: in which, Y is S or O, R1 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, aryl, heteroaryl or a polycyclic group, optionally substituted, R2 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl or aryl optionally substituted, R3 is X2—R?3, in which X2 is a binding group and R?3 is cycloalkyl, heterocycloalkyl, cycloalkenyl, aryl, heteroaryl, or a polycyclic group; optionally substituted, or their pharmaceutically acceptable derivatives, a compound of Formula I, for their preparation, and processes for pharmaceutical compositions containing methods of using the compounds for the treatment of disorders for which a treatment by a PDE7 inhibitor is relevant.

Abstract: The invention relates to novel substituted pyrazolo[4,3-e]-diazepines of general formula: to pharmaceutical compositions containing them, to their use as medicinal products and to processes for preparing them.

Abstract: The invention concerns a method for chemoselective oxidation of an organic compound comprising several potentially oxidizable groups whereof at least one is a nitrogen group. Said method is characterised in that it consists in using at least a protic solvent, which is a good donor of hydrogen bonds, enabling to limit N-oxidation.

Abstract: The present invention relates to triazolo[4,3-a]quinazoline-5-ones and 5-thiones of Formula I and Formula II, whereby I and II are position isomers of group R on nitrogen 3 or 4. Optionally, the invention also relates to the racemic forms, isomers and pharmaceutically acceptable salts thereof. The invention further relates to a method for the production thereof and to compositions containing said derivatives.

Abstract: A shaving assembly for simultaneously applying a shaving preparation and removing hair in a single step includes a base having an upper end, a lower end and a hollow space between the upper and lower ends, whereby the hollow space defines an opening at the upper end of the base. The shaving assembly includes a receiver for a razor, such as a cartridge receiver for a razor blade cartridge, that is connected with the base and that is disposed at the opening at the upper end of the base. The cartridge receiver has a perimeter and the opening at the upper end of the base completely surrounds the perimeter of the cartridge receiver. The hollow space of the base is adapted for containing a shaving preparation, such as a soap cake, a liquid soap, shaving cream or a body wash and may be combined with skin beneficial ingredients and/or scent.

Abstract: The invention relates to triazolo[4,3-a]pyrido[2,3-d]pyrimidine-5-one derivatives, their regioisomers, their salts and their solvates if they exist, their preparation, compositions containing them and their use. These derivatives possess properties inhibiting PDE4 and/or the release of TNF&agr;, and may therefore be used for the treatment or prevention of numerous conditions by virtue of the inhibition of the PDE4 enzyme and the resulting increase in the cAMP level.

Abstract: The invention relates to compounds of formula (I), in which R1, R2 and R3 are as defined in the description, their use as medicaments, the process for their preparation and their use for the treatment of pathologies in which therapy by a PDE4 inhibitor is relevant.

Abstract: Method for the preparation of enantiomerically pure diazepino-indolone of formula which comprises the intramolecular cyclization of a product of formula where A, B, X1, X2, Z, Z1, Z2 and R are as defined in the description, in the presence of a weak Lewis acid catalyst.

Abstract: A shaving assembly operable in dry shaving environments and wet shaving environments is provided that includes a razor assembly and a shaving preparation cake. The razor assembly, which includes a razor cartridge attached to a handle, is operable in dry shaving environments and wet shaving environments. The shaving preparation cake includes an upper surface, a lower surface, one or more side surfaces extending between the upper surface and the lower surface, and an axial bore extending between the upper surface and the lower surface. The shaving preparation cake is operable in a wet shaving environment, and is selectively attachable to the razor assembly for wet shaving environment applications. When the shaving preparation cake is attached to the razor assembly, the razor cartridge is disposed within the axial bore of the shaving preparation cake. The shaving preparation cake is selectively detachable from the razor assembly to facilitate use of the razor assembly in dry shaving environment applications.

Abstract: A razor cartridge is provided that includes a frame, one or more razor blades, a guard having a contact surface, and a plurality of scoop pockets disposed in the contact surface of the guard. The one or more razor blades are attached to the frame, and each has a cutting edge. The guard, which has a length and a width, is disposed forward of the one or more razor blades. Each of the scoop pockets has a base surface, a first side surface, and a second side surface that extend between an open end and an aft end. The open end of each scoop pocket is forward of the respective aft end. Each scoop pocket also includes an aft side surface contiguous with the aft end. The scoop pockets are distributed along the length of the guard.

Abstract: A razor cartridge is provided that includes a subframe, a frame, and one or more razor blades attached to the frame. The frame includes a cap, a forward end, and a cap end. The one or more razor blades are attached to the frame. The frame is pivotally mounted on the subframe and pivots about a pivot line that is positioned adjacent the cap and aft of the cutting edges of the one or more razor blades. The razor cartridge preferably further includes a spring mechanism that acts between the frame and the subframe.

Abstract: A razor assembly is provided that includes a handle having a cavity, a razor cartridge attached to a razor cartridge holder, and a shaving aid body. The razor cartridge holder is slidably received within the cavity of the handle. The shaving aid body is attached to the handle, and includes a contact surface and an aperture disposed in the contact surface that is sized to receive the razor cartridge. In some embodiments, one or more biasing members act between the handle and the razor cartridge holder.

Abstract: A shaving assembly for simultaneously applying a shaving preparation and removing hair in a single step includes a base having an upper end, a lower end and a hollow space between the upper and lower ends, whereby the hollow space defines an opening at the upper end of the base. The shaving assembly includes a receiver for a razor, such as a cartridge receiver for a razor blade cartridge, that is connected with the base and that is disposed at the opening at the upper end of the base. The cartridge receiver has a perimeter and the opening at the upper end of the base completely surrounds the perimeter of the cartridge receiver. The hollow space of the base is adapted for containing a shaving preparation, such as a soap cake, a liquid soap, shaving cream or a body wash and may be combined with skin beneficial ingredients and/or scent.