Patents Assigned to Washington Research Foundation
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Patent number: 5576189Abstract: Methods of determining collagen degradation in vivo, by quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a hydroxylysyl pyridinoline cross-link. Suitable methods include immunometric assays, fluorometric assays, and electrochemical titrations for quantitation. The structures of specific peptides having cross-links and kits for quantitating these peptides in a body fluid are described.Type: GrantFiled: June 1, 1995Date of Patent: November 19, 1996Assignee: Washington Research FoundationInventor: David R. Eyre
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Patent number: 5532169Abstract: A method of determining collagen degradation in vivo, comprising quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a hydroxylysyl pyridinoline cross-link. The method includes immunometric assays, fluorometric assays, and electrochemical titrations for quantitation. The structures of specific peptides having cross-links and kits for quantitating these peptides in a body fluid are described.Type: GrantFiled: January 16, 1992Date of Patent: July 2, 1996Assignee: Washington Research FoundationInventor: David R. Eyre
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Patent number: 5473052Abstract: Methods of determining collagen degradation in vivo, by quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a hydroxylysyl pyridinoline cross-link. Suitable methods include immunometric assays, fluorometric assays, and electrochemical titrations for quantitation. The structures of specific peptides having cross-links and kits for quantitating these peptides in a body fluid are described.Type: GrantFiled: April 1, 1994Date of Patent: December 5, 1995Assignee: Washington Research FoundationInventor: David R. Eyre
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Patent number: 5472884Abstract: Compositions useful in quantitating collagen peptides to determine the rate of bone resorption are prepared by treating bone with a protease, such as collagenase, and purifying the compositions so as to enrich them with peptides capable of binding to the monoclonal antibody MAb-1H11.Type: GrantFiled: April 19, 1994Date of Patent: December 5, 1995Assignee: Washington Research FoundationInventor: David R. Eyre
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Patent number: 5455179Abstract: A method of determining collagen degradation in vivo, comprising quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a hydroxylysyl pyridinoline cross-link. The method includes immunometric assays, fluorometric assays, and electrochemical titrations for quantitation. The structures of specific peptides having cross-links and kits for quantitating these peptides in a body fluid are described.Type: GrantFiled: April 11, 1994Date of Patent: October 3, 1995Assignee: Washington Research FoundationInventor: David R. Eyre
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Patent number: 5440011Abstract: Tetra(alkylene oxide)silicate polymers are obtained by reacting pentacoordinate and hexacoordinate silicon complexes with tetra(alkylene) glycol, generally in accordance with the following reaction, as represented by the hexacoordinate species: ##STR1## The resulting polymers are represented by the following general formula: ##STR2## wherein R.sub.1 through R.sub.5 contain a carbon atom bonded directly to an oxygen atom of the above structure and are independently selected from the group consisting of ##STR3## can be taken together to be --CH.sub.2 CH.sub.2 --, with the proviso that at least three or R.sub.1 through R.sub.5 must be, ##STR4## x is 0 or 1, each R.sub.6 is independently selected from H, OH, C.sub.1-6 alkyl, O--C.sub.1-6 alkyl, C.sub.2-6 alkene, C.sub.6-12 aryl, C.sub.1-6 hydroxyalkyl, C.sub.1-6 thioalkyl, C.sub.2-12 alkoxyalkyl, C.sub.Type: GrantFiled: November 9, 1994Date of Patent: August 8, 1995Assignee: Washington Research FoundationInventor: Richard M. Laine
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Patent number: 5434084Abstract: There is disclosed a device capable of continuously measuring the presence and concentration of an analyte or analytes and a method for using said device in a liquid and/or a gas phase reaction volume. The inventive device comprises a sensor probe, a reservoir, and a detector. The inventive device delivers reagent to the sensor probe in a flow method to directly and continuously renew reagent, thereby allowing the continuous measurement of the presence and the concentration of an analyte or analytes.Type: GrantFiled: September 6, 1989Date of Patent: July 18, 1995Assignees: The Washington Research Foundation, The Board of Regents of the University of WashingtonInventor: Lloyd W. Burgess, Jr.
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Patent number: 5399684Abstract: DNA sequences to mammalian .alpha..sub.1 -antitrypsin are provided which can be used for expression of mammalian .alpha..sub.1 -antitrypsin.Type: GrantFiled: July 2, 1993Date of Patent: March 21, 1995Assignee: Washington Research FoundationInventors: Earl W. Davie, Kotoku Kurachi, Savio L. C. Woo, Chandra Thirumalachary
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Patent number: 5350673Abstract: Methods for detecting a unique strain of Chlamydia associated with acute respiratory disease are disclosed. These methods utilize monoclonal antibody directed against an antigenic determinant of the TWAR organism, or DNA probes capable of specifically hybridizing to at least a portion of the DNA sequence of the TWAR organism. A method for determining the presence of antibodies to the TWAR organism, utilizing elementary bodies of the TWAR organism as antigen is also disclosed.Type: GrantFiled: January 24, 1994Date of Patent: September 27, 1994Assignee: Washington Research FoundationInventors: Lee A. Campbell, Chou-chou Kuo, J. Thomas Grayston
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Patent number: 5340829Abstract: Specific aspects of the cellular and humoral immune systems of a mammalian host are regulated by administering to the host a compound having a reactive immunoregulatory conformation whose precise three-dimensional structure is defined herein. Sorbinil, tolrestat, W-3681, and the other immunoregulatory agents described herein possess this reactive conformation and so are therapeutically useful for inhibiting delayed-type hypersensitivity, T-cell proliferation, and B-cell antibody production, without altering the normal cellularity of the immune system or the normal metabolites of the arachidonic acid pathway.Type: GrantFiled: December 15, 1992Date of Patent: August 23, 1994Assignee: Washington Research FoundationInventors: John I. Clark, Andrew G. Farr, Stacia A. Smith
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Patent number: 5320970Abstract: Methods of determining collagen degradation in vivo, by quantitating the concentration of a peptide in a body fluid, the peptide having the following structure: ##STR1## is hydroxylysyl pyridinoline or lysyl pyridinoline, and J is pyroglutamic acid or glutamine and (Leu) are optional leucines, are disclosed.Compositions useful in quantitating collagen peptides to determine the rate of bone resorption are prepared by treating bone with a protease, such as collagenase, and purifying the compositions so as to enrich them with peptides capable of binding to the monoclonal antibody MAb-1H11.Type: GrantFiled: May 31, 1991Date of Patent: June 14, 1994Assignee: Washington Research FoundationInventor: David R. Eyre
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Patent number: 5320947Abstract: Methods for the detection, monitoring and treatment of malignancies are disclosed. Detection of the proliferation of T cells in response to in vitro exposure to a protein expression product of an activated oncogene or cancer-related gene associated with a malignancy, or detection of immunocomplexes formed between the protein expression product and antibodies in body fluid, allows the diagnosis of the presence of a malignancy. The present invention also discloses methods and compositions for treating a malignancy.Type: GrantFiled: January 13, 1992Date of Patent: June 14, 1994Assignee: Washington Research FoundationInventors: Martin A. Cheever, David J. Peace
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Patent number: 5308760Abstract: Two genes encoding the predominant polypeptides of Bacillus thuringiensis subsp. thompsoni cuboidal crystals were cloned in Escherichia coli and sequenced. The new class of crystal proteins have electrophoretic mobilities of 40 and 34 kilodaltons (kDa) with the deduced amino-acid sequences predicting molecular masses of 35,384 and 37,505 daltons, respectively. No statistically significant similarities were detected for the 40 kDa and 34 kDa crystal proteins to any other characterized Bacillus thuringiensis crystal protein or to each other. A 100 MDa plasmid encodes both crystal protein genes, which appear to be part of an operon with the 40 kDa gene 64 nucleotides upstream of the 34 kDa gene. Both crystal proteins are synthesized in approximately the same amounts. Even though small, compared to other crystal proteins, the 34 kDa crystal protein has insecticidal activity against lepidopteran larvae (Manduca sexta).Type: GrantFiled: February 3, 1992Date of Patent: May 3, 1994Assignee: Washington Research FoundationInventors: Kit L. Brown, Helen R. Whiteley, deceased
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Patent number: 5300434Abstract: Methods of determining collagen degradation in vivo, by quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a hydroxylysyl pyridinoline cross-link. Suitable methods include immunometric assays, fluorometric assays, and electrochemical titrations for quantitation. The structure of specific peptides having cross-links and kits for quantitating these peptides in a body fluid are described.Type: GrantFiled: November 21, 1990Date of Patent: April 5, 1994Assignee: Washington Research FoundationInventor: David R. Eyre
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Patent number: 5281518Abstract: Methods for detecting a unique strain of Chlamydia associated with acute respiratory disease are disclosed. These methods utilize monoclonal antibody directed against an antigenic determinant of the TWAR organism, or DNA probes capable of specifically hybridizing to at least a portion of the DNA sequence of the TWAR organism. A method for determining the presence of antibodies to the TWAR organism, utilizing elementary bodies of the TWAR organism as antigen is also disclosed.Type: GrantFiled: September 16, 1992Date of Patent: January 25, 1994Assignee: Washington Research FoundationInventors: Lee A. Campbell, Chou-chou Kuo, Thomas Grayston
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Patent number: 5216155Abstract: Silicon and aluminum complexes having the following formula I, II or III: ##STR1## wherein x is 0 or 1, T is H or ##STR2## each R is independently selected from the group consisting of H, OH, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.2-6 alkene, C.sub.6-12 aryl, C.sub.1-6 hydroxyalkyl, C.sub.1-6 thioalkyl, C.sub.2-12 alkoxyalkyl, C.sub.3-20 heteroaromatic, and combinations thereof, wherein R may further contain one or more atoms of a non-carbon element such as Si, Ge, Sn, P, and the like; Y is a cation, and Z is a multivalent cation, are prepared by reacting silica or alumina with a diol, in the presence of a base, while removing water formed during the reaction. Methods for producing such complexes starting with silica or alumina, and methods for converting such complexes into other silicon or aluminum-containing compounds, are disclosed.Type: GrantFiled: November 12, 1991Date of Patent: June 1, 1993Assignee: Washington Research FoundationInventors: Richard M. Laine, Kay A. Youngdahl
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Patent number: 5208491Abstract: A field programmable gate array (FPGA) comprising routing and logic blocks (RLBs) and segmented routing channels is disclosed. Each RLB is configurable to perform both logic functions and routing functions. A plurality of forwardly propagating RLBs (FPRLBs) and a plurality of backwardly propagating RLBs (BPRLBs) intermesh with one another to form a two-dimensional checkerboard array. Each column of the RLB array comprises a plurality of FPRLBs and BPRLBs in alternating sequence. Similarly, each row of the RLB array comprises a plurality of FPRLBs and BPRLBs in alternating sequence. The FPRLBs forwardly propagate signals and the BPRLBs backwardly propagate signals. Each FPRLB may receive a plurality of input signals from a plurality of FPRLBs in the preceding leftward column. Moreover, each FPRLB may output a plurality of output signals to a plurality of FPRLBs in the next rightward column.Type: GrantFiled: January 7, 1992Date of Patent: May 4, 1993Assignee: Washington Research FoundationInventors: William H. C. Ebeling, Gaetano Borriello
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Patent number: 5151900Abstract: A chaos router system for routing messages between connected nodes in a multicomputer or multiprocessor system is disclosed. In such a system, a message may be routed between nodes along a preferred channel so that it is closer to its destination or derouted between nodes along a random channel so that it is further from its destination. The chaos router system explicitly randomizes message selection during derouting. In an asynchronous multicomputer system, the router system keeps the overall system chaotic. In this manner, the system is probabilistically livelock free.Type: GrantFiled: June 14, 1991Date of Patent: September 29, 1992Assignee: Washington Research FoundationInventors: Lawrence Snyder, Smaragda Konstantinidou
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Patent number: 5140103Abstract: A method of determining collagen degradation in vivo, including quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a hydroxylysyl pyridinoline cross-link. The method includes immunometric assays, fluorometric assays, and electrochemical titrations for quantitation. The structures of specific peptides having cross-links and kits for quantitating these peptides in a body fluid are described.Type: GrantFiled: December 1, 1989Date of Patent: August 18, 1992Assignee: Washington Research FoundationInventor: David R. Eyre
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Patent number: 5130563Abstract: A neural network for processing sensory information. The network comprise one or more layers including interconnecting cells having individual states. Each cell is connected to one or more neighboring cells. Sensory signals and signals from interconnected neighboring cells control a current or a conductance within a cell to influence the cell's state. In some embodiments, the current or conductance of a cell can be controlled by a signal arising externally of the layer. Each cell can comprise an electrical circuit which receives an input signal and causes a current corresponding to the signal to pass through a variable conductance. The conductance is a function of the states of the one or more interconnecting neighboring cells. Proper interconnection of the cells on a layer can produce a neural network which is sensitive to predetermined patterns or the passage of such patterns across a sensor array whose signals are input into the network.Type: GrantFiled: June 7, 1991Date of Patent: July 14, 1992Assignee: Washington Research FoundationInventors: Bahram Nabet, Robert B. Darling, Robert B. Pinter