Patents Assigned to Washington University in St. Louis
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Patent number: 11858956Abstract: The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds.Type: GrantFiled: December 17, 2021Date of Patent: January 2, 2024Assignees: Southern Research Institute, Oregon Health & Science University, Washington University in St. Louis, Board of Regents, The University of Texas SystemInventors: Omar Moukha-Chafiq, Ashish Kumar Pathak, Shuklendu D. Karyakarte, Larry D. Bratton, Corinne E. Augelli-Szafran, Michael Diamond, Pei Yong Shi, Alec Jay Hirsch, Jessica Lee Smith, Daniel Streblow, Nicole Haese, Baoling Ying
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Patent number: 11717519Abstract: Methods of using small molecule inhibitors of fatty acid oxidation (FAO) as antimicrobials against intracellular Mycobacteria are disclosed. FAO inhibitors including etomoxir, trimetazidine, oxfenicine perhexeline and/or can be used alone, or in combination with known as antimycobacterial agents against intracellular Mycobacteria.Type: GrantFiled: March 15, 2019Date of Patent: August 8, 2023Assignees: Washington University in St. Louis, New York UniversityInventors: Jennifer A. Philips, Kathryn Moore, Pallavi Chandra, Mireille Ouimet
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Patent number: 11597917Abstract: The present invention is related to a dual promoter lentiviral vector and methods of use for the treatment of diseases and disorders, specifically lysosomal storage disorders.Type: GrantFiled: June 6, 2018Date of Patent: March 7, 2023Assignees: The Medical College of Wisconsin, Inc., University Health Network, Washington University in St. LouisInventors: Jeffrey A. Medin, John F. Dipersio, Murtaza S. Nagree
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Patent number: 11154201Abstract: Provided are implantable biomedical devices and related methods for interfacing with a target tissue. The devices comprise a substrate, an electronic device supported by the substrate and a freely positionable injectable needle electronically connected to the electronic device by a deformable interconnect, where the injectable needle has one or more optical sources provided on a distal tip end. The injectable needle may further comprise a photodetector.Type: GrantFiled: March 31, 2017Date of Patent: October 26, 2021Assignees: The Board of Trustees of the University of Illinois, Washington University in St. LouisInventors: John A. Rogers, Gunchul Shin, Anthony R. Banks, Michael Bruchas, Robert Gereau
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Patent number: 11129816Abstract: Described is a composition that includes: (i) a drug against tuberculosis inhibiting the cytochrome b subunit of the bc1 complex, said cytochrome b subunit being encoded by the gene qcrB, in Mycobacterium tuberculosis, or a pharmaceutically acceptable salt thereof, and (ii) a compound of Formula II, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: October 5, 2018Date of Patent: September 28, 2021Assignees: Quretech Bio AB, Washington University in St. LouisInventors: Christina Leigh Stallings, Gregory Alexander Harrison, Fredrik Almqvist, Souvik Sarkar
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Patent number: 11085933Abstract: The present disclosure is generally related to neurofibromatosis type 1. More particularly, disclosed herein are methods for detecting behavioral disorders, methods for detecting cognitive impairment, and methods for detecting brain neurofibromin-dependent dopaminergic signaling associated with neurofibromatosis type 1.Type: GrantFiled: October 4, 2019Date of Patent: August 10, 2021Assignee: Washington University in St. LouisInventors: David H. Gutmann, Corina Anastasaki
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Publication number: 20210000471Abstract: An arteriovenous graft and methods of reducing the risk of graft thrombosis and extending patency of the arteriovenous graft are provided herein. The arteriovenous graft is operable for attaching to a vein at a venous anastomosis. In some aspects, the arteriovenous graft includes a plurality of grooves at a venous anastomosis end of the arteriovenous graft and the venous anastomoses may be arranged such that the arteriovenous graft and the vein meet at an angle of 30° or less.Type: ApplicationFiled: July 2, 2020Publication date: January 7, 2021Applicant: Washington University, St. Louis, MOInventors: Mohamed Zayed, Dillon Williams, Guy Genin, Eric Leuthardt
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Patent number: 10813941Abstract: A pharmaceutical composition includes a small molecule and a pharmaceutically acceptable excipient. The small molecule interacts with a deoxyxylulose phosphate reductoisomerase (Dxr). A method for treating or preventing a microbial infection in a subject in need thereof includes administering the pharmaceutical composition. A method for inhibiting the growth of a eukaryotic pathogen includes contacting the eukaryotic pathogen with an effective amount of the pharmaceutical composition.Type: GrantFiled: January 23, 2017Date of Patent: October 27, 2020Assignees: The George Washington University, A Congressionally Chartered Not-For-Profit Corporation, Washington University in St. LouisInventors: Cynthia Dowd, Audrey Odom, Rachel Edwards, Robert Brothers
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Publication number: 20200140469Abstract: The present disclosure relates to novel compounds, pharmaceutical compositions, and methods for treating or preventing microbial infection caused by parasites or bacteria, such as Plasmodium falciparum or related Plasmodium parasite species and Mycobacterium tuberculosis or related Mycobacterium bacteria species. The compounds are ?,?-unsaturated analogs of fosmidomycin and can inhibit deoxyxylulose phosphate reductoisomerase (Dxr) in many microbes, such as P. falciparum.Type: ApplicationFiled: June 27, 2018Publication date: May 7, 2020Applicants: The George Washington University, Washington University in St. Louis, George Mason University, Saint Louis UniversityInventors: Cynthia Dowd, Xu WANG, Robert Carl BROTHERS, Audrey Ragan Odom JOHN, Rachel EDWARDS, Marvin MEYERS, Stacy ARNETT, Robin COUCH, Kenneth HEIDEL
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Publication number: 20190090801Abstract: Provided are implantable, injectable and/or surface mounted biomedical devices and related methods for interfacing with a target tissue. The devices have a substrate, one or more microfluidic channels embedded in or supported by the substrate and a fluid actuator in operational communication with one or more reservoirs and responsive to a wireless control signal. The components of the device are specially configured and packaged to be ultra-thin and mechanically compliant. In some embodiments, the devices are self-powered and fully implantable. The devices can be shaped to provide injection in a minimally invasive manner, thereby avoiding unnecessary tissue damage and providing a platform for long-term implantation for interfacing with biological tissue.Type: ApplicationFiled: July 1, 2016Publication date: March 28, 2019Applicants: WASHINGTON UNIVERSITY IN ST. LOUIS, The Board of Trustee of the University of IllinoisInventors: John A. ROGERS, Michael Raymond BRUCHAS, Jaewoong JEONG, Jordan Gary MCCALL
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Patent number: 10241110Abstract: Plasmonic nanotransducers, methods of preparing plasmonic nanotransducers, and methods for label-free detection of target molecules are disclosed. The plasmonic nanotransducers include hollow nanostructure cores and artificial antibodies. The plasmonic nanotransducers are exposed to a biological sample that can contain the specific target molecules. The plasmonic nanotransducers can be analyzed with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the target molecule in the sample.Type: GrantFiled: October 17, 2014Date of Patent: March 26, 2019Assignee: Washington University in St. LouisInventors: Srikanth Singamaneni, Limei Tian, Keng-Ku Liu, Abdennour Abbas, Jeremiah J. Morrissey, Evan D. Kharasch
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Publication number: 20190030056Abstract: A pharmaceutical composition includes a small molecule and a pharmaceutically acceptable excipient. The small molecule interacts with a deoxyxylulose phosphate reductoisomerase (Dxr). A method for treating or preventing a microbial infection in a subject in need thereof includes administering the pharmaceutical composition. A method for inhibiting the growth of a eukaryotic pathogen includes contacting the eukaryotic pathogen with an effective amount of the pharmaceutical composition.Type: ApplicationFiled: January 23, 2017Publication date: January 31, 2019Applicants: THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALL A CONGRESSIOY CHARTERED NOT-FOR-PROFIT CORPORATIO, WASHINGTON UNIVERSITY IN ST. LOUISInventors: Cynthia DOWD, Audrey ODOM, Rachel Edwards, Robert BROTHERS
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Patent number: 9980660Abstract: A non-transitory computer readable medium stores instructions that, when executed by at least one processor, cause the at least one processor to perform a method that includes computing a transfer matrix representing a relative influence that each respective electrode location for measuring electrical potentials on a patient's body has on an estimation of electrical potentials for locations on a surface of interest prior to the measuring of electrical potentials at the respective electrode locations and receiving electrical potential measurements measured via a plurality of electrodes at respective electrode locations on the patient's body. The method also includes computing the estimation of electrical potentials for the locations on the surface of interest based at least in part on the received electrical potential measurements and the computed transfer matrix and generating image data representing the estimation of electrical potentials.Type: GrantFiled: January 7, 2016Date of Patent: May 29, 2018Assignee: Washington University in St. LouisInventors: Yoram Rudy, Yong Wang
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Patent number: 9410949Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.Type: GrantFiled: December 2, 2011Date of Patent: August 9, 2016Assignee: Washington University in St. LouisInventors: Srikanth Singamaneni, Evan Kharasch, Jeremiah J. Morrissey, Chang Hee Lee
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Patent number: 9259166Abstract: A computer-implemented method for electrocardiographic imaging (ECGI) is provided. The method includes computing a transfer matrix, measuring a plurality of electrical potentials, and computing an estimation of electrical potentials on a surface of interest based at least in part on the measured potentials and the computed transfer matrix. The transfer matrix computing step is performed prior to the measuring step.Type: GrantFiled: August 10, 2009Date of Patent: February 16, 2016Assignee: Washington University in St. LouisInventors: Yoram Rudy, Yong Wang
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Patent number: 9095601Abstract: A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2?-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.Type: GrantFiled: December 5, 2012Date of Patent: August 4, 2015Assignee: WASHINGTON UNIVERSITY IN ST. LOUISInventors: Matthew L. Becker, Huafeng Fang, Xiaoxu Li, Dipanjan Pan, Raffaella Rossin, Xiankai Sun, John Stephen Taylor, Jeffrey L. Turner, Michael John Welch, Karen L. Wooley
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Publication number: 20150185187Abstract: A probe for use with an imaging system, including a scanning device configured to receive a first light beam from a light source, a beam-divider configured to split the first light beam into a plurality of second light beams, and a focusing device configured to focus each of the second light beams on respective locations in an object of interest is disclosed.Type: ApplicationFiled: March 5, 2015Publication date: July 2, 2015Applicant: WASHINGTON UNIVERSITY IN ST. LOUISInventors: Lihong Wang, Liang Song, Konstantin Maslov, Bin Rao
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Publication number: 20150141767Abstract: Provided are devices and methods capable of interfacing with biological tissues, such as organs like the heart, in real-time and using techniques which provide the ability to monitor and control complex physical, chemical, biochemical and thermal properties of the tissues as a function of time. The described devices and methods utilize micro scale sensors and actuators to spatially monitor and control a variety of physical, chemical and biological tissue parameters, such as temperature, pH, spatial position, force, pressure, electrophysiology and to spatially provide a variety of stimuli, such as heat, light, voltage and current.Type: ApplicationFiled: October 2, 2014Publication date: May 21, 2015Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, WASHINGTON UNIVERSITY IN ST. LOUISInventors: John A. ROGERS, Igor EFIMOV, Sarah GUTBROD, Lizhi XU, Andrew BONIFAS, Richard Chad WEBB, Ahyeon KOH
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Patent number: 8889378Abstract: The invention provides methods for identifying a compound that inhibits cytochrome c synthesis. This invention further provides a method for the high throughput screening of compounds that inhibit cytochrome c synthesis.Type: GrantFiled: July 7, 2010Date of Patent: November 18, 2014Assignee: Washington University in St. LouisInventor: Robert Kranz
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Publication number: 20140234841Abstract: In one aspect, the disclosure provides isolated nucleic acids, polypeptides, primers, and probes for the detection of mutations in a nucleic acid sequence for a DICER1 polypeptide.Type: ApplicationFiled: April 30, 2014Publication date: August 21, 2014Applicants: Children's Hospital and Clinics of Minnesota, The Washington University in St. LouisInventors: Ashley D. Hill, Paul Goodfellow, John R. Priest, Yoav Messinger