Abstract: A novel function phospholipase A2, referred to herein as calcium-independent phospholipase A2? (iPLA2?) having SEQ ID NO: 1 and SEQ ID NO: 2, and nucleic acid sequences (SEQ ID NO: 3 and SEQ ID NO: 4) encoding and expressing iPLA2? is disclosed. This novel enzyme has been isolated and characterized and is involved in the catalysis and hydrolysis of lipids cycling in a living cell biosystem. In an embodiment, the iPLA2? polypeptide is encoded and expressed by an isolated nucleic acid molecule comprising a set of iPLA2? polynucleotides. In one aspect, an isolated and characterized gene comprises a polynucleotide having a sequence shown in SEQ ID NO: 3 and SEQ ID NO: 4.

Abstract: A process for resolution of racemic BEL into its individual enantiomeric constituents by chiral HPLC. A method for determining the role of specific isoforms of iPLA2 in biologic processes.

Abstract: A method for aiding in the determination of whether a living or deceased human is afflicted with or will likely have atherosclerosis respectfully, the method comprising determining the level of SPRR3 protein in a intimae or body fluid sample by using molecular localization analysis technique comparing the determined level of SPRR3 protein in the biological sample obtained from said individual with a range of SPRR3 levels previously defined as characteristic for humans having atherosclerosis, concluding from the comparison that the person is likely suffering from atherosclerosis when a SPRR3 level is in the range previously defined as characteristic for the presence of atherosclerosis as an indication that the individual is suffering from or has suffered from atherosclerosis.

Abstract: A patient's image data and associated metadata describing the image data and characteristics of the patient are received and stored in a memory area. Information that describes one or more imaging analysis services and associated service criteria is accessed and compared to the metadata. Based on matches between the image metadata and service criteria, services are selected and executed, producing an output. Iterative rounds of service matching based on the metadata and the output of previous services and service execution proceed. The output of the services is associated with the image data and metadata, stored in the memory area, and made available to the user. A data repository, including the original images, metadata, and service output is accessible via the services for use in comparative analyses. Such services can utilize the repository to dynamically update indices and algorithms used in the comparative analyses.

Abstract: A novel function phospholipase A2, referred to herein as calcium-independent phospholipase A2? (iPLA2?) having SEQ ID NO: 1 and SEQ ID NO: 2, and nucleic acid sequences (SEQ ID NO: 3 and SEQ ID NO: 4) encoding and expressing iPLA2? is disclosed. This novel enzyme has been isolated and characterized and is involved in the catalysis and hydrolysis of lipids cycling in a living cell biosystem. In an embodiment, the iPLA2? polypeptide is encoded and expressed by an isolated nucleic acid molecule comprising a set of iPLA2? polynucleotides. In one aspect, an isolated and characterized gene comprises a polynucleotide having a sequence shown in SEQ ID NO: 3 and SEQ ID NO: 4.

Abstract: A method for obtaining data while facilitating keeping a minimum amount of state is provided. The method includes receiving at a first device an Internet Protocol (IP) frame sent from a second device to a third device wherein the first device is in a flow path between the second and third devices, the first device including at least one of an Application Specific Integrated Circuit (ASIC) and a Field Programmable Gate Array FPGA. The method also includes removing an embedded stream-oriented protocol frame including a header and a data packet from the received IP frame with at least one of the ASIC and the FPGA, and determining a validity of a checksum of the removed steam-oriented protocol header.

Abstract: A system, method, and device for imaging a sample. In embodiments, a light from a low-coherence source or a wavelength-swept source is used to illuminate the sample. Pathlength-resolved intensity profiles of the light reemitted from the sample are recorded and measurements are taken. A reconstruction algorithm is used to invert the pathlength-resolved measurements to form an image.

Abstract: The invention generally relates to the use of archaea to modulate nutrient harvesting in a subject. In particular, the invention provides methods that use archaea to modulate the nutrient harvesting functions of the microbiota in the subject's gastrointestinal tract.

Abstract: A device and method for providing stimulation to an inferior nodal extension of a heart. The method includes providing a lead comprising an electrode, positioning the electrode proximate an inferior nodal extension of a heart, and effecting at least one of activation, deactivation, or modulation of the electrode to provide stimulation to the inferior nodal extension.

Abstract: Methods of enhancing cellular responses to interferons are disclosed. These methods comprise administering to a subject a vector comprising a Stat1-CC transgene, such as an AAV5 vector comprising a reporter operably linked to a nucleic acid sequence encoding a Stat1-CC polypeptide. The methods can be used in the treatment of diseases that involve interferon responses, such as multiple sclerosis, amyotrophic lateral sclerosis, and lupus; viral infections such as infection by hepatitis C virus, influenza A virus, cowpox virus, Sendai virus or Encephalomyocarditis virus; respiratory disorders; and cancers.

Abstract: An apparatus for measuring particle size distribution includes a charging device and a precipitator. The charging device includes a corona that generates charged ions in response to a first applied voltage, and a charger body that generates a low energy electrical field in response to a second applied voltage in order to channel the charged ions out of the charging device. The corona tip and the charger body are arranged relative to each other to direct a flow of particles through the low energy electrical field in a direction parallel to a direction in which the charged ions are channeled out of the charging device. The precipitator receives the plurality of particles from the charging device, and includes a disk having a top surface and an opposite bottom surface, wherein a predetermined voltage is applied to the top surface and the bottom surface to precipitate the plurality of particles.

Abstract: A method for utilizing an optical system for mapping brain function includes determining a time series of light intensity measurements for spatially distributed source and detector pairs, receiving light measurements over a period of time, and producing at least one map of a respective strength of each of a plurality of temporal correlations, wherein the temporal correlations are based on the time series of the spatially distributed source and detector pairs and the light measurements.

Abstract: The present invention relates to methods of inhibiting seizure in a subject. In particular, the invention provides methods of increasing brain leptin levels in a subject.

Abstract: The invention encompasses biomarkers for AD, a method for detecting AD, a method of monitoring AD, and a kit for quantifying biomarkers for AD.

Abstract: The invention provides methods of delaying the onset, slowing the progression, preventing, or treating Alzheimers disease in a subject. In particular, the invention provides methods of modulating transport of A? across the blood brain barrier of the subject.

Abstract: A method and a related composition for treating gastrointestinal radiation sensitivity in a subject are disclosed. The method comprises administering to the subject an agent that increases either the amount of or the activity of a fasting-induced adipose factor (Fiaf) protein in a subject. The composition comprises a first agent that increases either the amount of or the activity of a fasting-induced adipose factor (Fiaf) protein in a subject and a second agent that ameliorates at least one symptom of gastrointestinal radiosensitivity in a subject.

Abstract: The invention generally relates to substrates and surfaces having substrates. Generally speaking, the substrates may be thinly layered substrates, and the surfaces may comprise thinly layered substrates. Additionally, the substrates may comprise a multifunctional water soluble polymer and a lipoprotein and the surfaces may comprise a multifunctional water soluble polymer and a lipoprotein.

Abstract: The present invention encompasses methods for treating neurofibromatosis and methods for screening for modulators of the neurofibromin pathway.

Abstract: Determining an index for assessing cardiac function. In an embodiment, a method includes receiving ventricular pressure data during an invasive cardiac procedure, wherein the received pressure data includes a diastatic ventricular pressure value, a minimum ventricular pressure value, and a predefined fiducial marker pressure value. An index value is calculated by comparing a first pressure difference to a second pressure difference. The first pressure difference represents the difference between the received diastatic ventricular pressure value and the received minimum ventricular pressure value. The second pressure difference represents the difference between the received fiducial marker pressure value and the received minimum ventricular pressure value. The index value is provided to a health care provider to assess early diastolic cardiac function.

Abstract: The present invention provides the identification of human Ras palmitoyl acyl transfersase complexes, and nucleic acids coding therefor. In addition, methods of screening for modulators of human Ras palmitoyl acyl transfersase, including high throughput yeast screens, are also provided.