Abstract: The present disclosure relates to methods and compositions utilizing upper-airway microbiota for diagnosing individuals at risk for asthma exacerbations. Further provided herein are probiotic compositions and methods for treating asthma by administering microorganisms that are associated with decreased risk of asthma exacerbations.
Type:
Application
Filed:
December 14, 2021
Publication date:
June 30, 2022
Applicants:
The Jackson Laboratory, Washinton University
Inventors:
Yanjiao Zhou, Avraham Beigelman, Leonard Bacharier, George Weinstock
Abstract: A non-invasive method for the determination of oxidative stress in a patient by urinalysis is disclosed. The method comprises quantifying the level of o,o'-dityrosine in a sample of the urine of said patient and comparing with the corresponding level of said compound in a normal or control sample, whereby a substantially elevated level of said o,o'-dityrosine is indicative of oxidative stress in said patient.