Abstract: A valve for dispensing the fluid contents of a container such that external contaminants such as dust, air or microbes cannot enter the container even after repeated dispensing cycles. The valve comprises a plug-type valve and an elastomeric sheath type valve such as a flapper valve, slit valve, or duck bill valve. All are one-way devices. The plug is provided with a mechanism for resetting it to the closed position at the end of each delivery cycle such that the plug is a one-way device also. The mechanism can be an elastomeric tether, gravity, or the deformation of a valve part. The plug can be provided with channels or other cut or shaped features, e.g. grooves, to facilitate fluid flow. The container used with this invention must be volumetrically reducible and thereby maintain its own internal pressure at the end of a delivery cycle. Alternatively, the valve of the present invention can be made without the outlet valve i.e., the flapper, slit, or duck bill valve.

Abstract: A modular cap delivery system comprising an elastomeric seal and conformably engaging seat can be affixed to or integrated in the neck of a container such as a bottle, flexible bag, tube, or any container having a neck and holding a quantity of a flowable medium. The configuration of the seal and seat eliminate the influx of air, airborne pathogens, or any contaminant into the container of flowable medium to which the delivery device is attached, thereby maintaining the integrity and sterility of a flowable material, even when challenged by direct contact through immersion in suspensions of bacteria or viruses. The delivery device is highly scalable in size, can work for viscous fluids that are difficult to flow, and enables a flowable material to be reformulated without preservatives or antioxidants. This provides the advantage of an enhanced therapeutic effect for many medications, particularly eye care solutions.

Abstract: A system is provided for contamination free delivery and control of a flowable medium contained in an enclosed flow path or a container. The system is highly scalable in size and works even with viscous fluids which are difficult to flow. The device enables a flowable material to be formulated without anti-oxidants, preservatives or anti microbial agents. This provides the advantage of an enhanced therapeutic effect for many medications, especially those which are considered labile. The device also preserves the integrity and sterility of a flowable material contained in an enclosed flow path such as blood plasma, and is effective against microbial as well as viral challenges. The device can be used to maintain the carbonation of a carbonated flowable medium. The system provides a seat and reversibly deformable seal disposed in the flow path; wherein the seal and seat are moveable between a closed and open state upon the deformation of the seal.