Abstract: Novel end fitting assemblies of particular advantage for use on liquid chromatographic columns, and novel chromatographic columns comprising these novel end fittings. The end-fittings are characterized by (a) very low dead space; (b) economical and convenient replacement of wearing parts; with minimal disturbing of the packed column, or other functional end-fitting components such as cones, filters, etc. A particular advantage is the design whereby the connector portions of the fitting assembly are not normally wetted by process fluids during operation of the column. Thus, the connector portions of the assemblies can be selected from a wide variety of mechanically-desirable materials selected for their wearing characteristics. Moreover, the fittings can be tightened for high-pressure operation without damage to the structure of the column of which they are used.