Abstract: The invention relates to a method for treating overactive bladders and a device for storing and administering non-occluded oxybutynin topical compositions.
Type:
Grant
Filed:
October 22, 2013
Date of Patent:
February 16, 2016
Assignee:
Watson Pharmaceuticals, Inc.
Inventors:
Scott Gochnour, Venkatesh Subramanyan, Michael W. Kimball
Abstract: The present disclosure provides mucoadhesive aqueous-based gel formulations of metronidazole useful for a variety of purposes, including intravaginal application as a therapeutic approach towards the treatment of individuals suffering from and/or diagnosed with bacterial vaginosis.
Type:
Grant
Filed:
August 23, 2012
Date of Patent:
December 1, 2015
Assignee:
Watson Pharmaceuticals, Inc.
Inventors:
Michael T. Nordsiek, Kodumudi S. Balaji
Abstract: A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a thiazolidinedione derivative is herein disclosed and described.
Type:
Grant
Filed:
June 2, 2011
Date of Patent:
June 25, 2013
Assignee:
Watson Pharmaceuticals, Inc.
Inventors:
Unchalee Kositprapa, Robert I. Goldfarb, John R. Cardinal, Avinash Nangia
Abstract: A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a thiazolidinedione derivative is herein disclosed and described.
Type:
Grant
Filed:
July 14, 2010
Date of Patent:
November 13, 2012
Assignee:
Watson Pharmaceuticals, Inc.
Inventors:
Unchalee Kositprapa, Avinash Nangia, John Cardinal, Robert I. Goldfarb
Abstract: The present invention relates to a novel controlled release dosage form that releases therapeutic amounts of a sedative or hypnotic agent rapidly after administration and maintains therapeutic levels for about eight hours after administration.
Abstract: It has been discovered that silodosin is effective in treating patients having symptoms associated with prostatitis with silodosin or a pharmaceutically acceptable salt thereof. In a preferred embodiment, patients are treated with 4 mg once daily.
Type:
Application
Filed:
February 23, 2011
Publication date:
July 19, 2012
Applicant:
WATSON PHARMACEUTICALS, INC.
Inventors:
Gary HOEL, Lawrence HILL, Kim CARAMELLI
Abstract: A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a thiazolidinedione derivative and a disintegrating agent is herein disclosed and described. The dosage formulation exhibits a significant increase in bioavailability of the thiazolidinedione derivative component compared to conventional immediate release dosage forms containing only a thiazolidinedione derivative.
Abstract: A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a thiazolidinedione derivative is herein disclosed and described.
Type:
Application
Filed:
June 2, 2011
Publication date:
October 27, 2011
Applicant:
WATSON PHARMACEUTICALS, INC.
Inventors:
Unchalee Kositprapa, Robert I. Goldfarb, John R. Cardinal, Avinash Nangia
Abstract: A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a thiazolidinedione derivative is herein disclosed and described.
Type:
Grant
Filed:
February 12, 2004
Date of Patent:
June 14, 2011
Assignee:
Watson Pharmaceuticals, Inc.
Inventors:
Unchalee Kositprapa, Robert I. Goldfarb, John R. Cardinal, Avinash Nangia
Abstract: A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a thiazolidinedione derivative is herein disclosed and described.
Type:
Grant
Filed:
September 19, 2003
Date of Patent:
August 31, 2010
Assignee:
Watson Pharmaceuticals, Inc.
Inventors:
Unchalee Kositprapa, Robert I. Goldfarb, John Cardinal, Avinash Nangia
Abstract: The present invention concerns an extended release formulation having an accelerating erosion and/or dissolution rate of the surface of the formulation. The formulation comprises a drug having low solubility in water dispersed or dissolved in at least one erasable hydrophilic polymeric matrix.
Abstract: The present invention provides compositions, methods, and kits for improving health in a woman having elevated SHBG levels, or who is receiving oral estrogen supplementation, by non-orally administering an effective amount of an androgenic steroid. Further, the present invention provides compositions, methods, and kits for coadministering an effective amount of an orally administered estrogen and an effective amount of a non-orally administered androgenic steroid for women in need of estrogen supplementation.
Type:
Grant
Filed:
October 22, 2002
Date of Patent:
March 6, 2007
Assignee:
Watson Pharmaceuticals, Inc.
Inventors:
Theresa Rosario-Jansen, Norman A. Mazer
Abstract: The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder. In some aspects, the composition may be presented in the form of an unoccluded or free form topically administered gel.
Abstract: Oral progesterone unit dosage forms comprising micronized progesterone and a solid polymeric carrier are provided. The dosage forms, upon oral administration, provide a therapeutically effective blood level of progesterone to a subject. The therapeutically effective blood level of progesterone may range from about 0.1 ng/ml to about 400 ng/ml. The dosage forms can be prepared for immediate as well as sustained release. The oral progesterone dosage form can be combined with an estrogen dosage form to provide combination hormone therapy.
Type:
Grant
Filed:
February 24, 2003
Date of Patent:
March 15, 2005
Assignee:
Watson Pharmaceuticals, Inc.
Inventors:
David Chung Hsia, Thomas Chun Ho, Domingo Yap Tan, Fredric B. Weihmuller
Abstract: The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder.
Abstract: Transdermal systems for providing sustained delivery of a drug over a lengthy duration are disclosed and described. In certain aspects, such systems may take the form of a transdermal patch that includes, in addition to traditional components such as a backing member and a peelable release liner, a polymeric storage layer, a polymeric delivery layer, and a rate controlling member disposed therebetween.
Abstract: Methods for the prevention or amelioration of urinary incontinence are disclosed and described. One method includes the coadministration of an anticholinergic agent with either an SSRI, or an SNRI, or both.