Abstract: Provided are ibrutinib polymorphs, e.g., crystalline ibrutinib Forms III, IV, V, VI, VII, VIII and Form IX and processes for producing these crystalline forms, stable amorphous ibrutinib and processes for preparing stable amorphous ibrutinib, pharmaceutical compositions comprising these forms and methods of using these crystalline and amorphous forms.
Type:
Grant
Filed:
December 22, 2017
Date of Patent:
May 7, 2019
Assignee:
WAVELENGTH ENTERPRISES LTD
Inventors:
Itai Adin, Sonia Krivonos, Yevgeny Rozenblat, Alex Weisman, Ana Fernandez Casares, Gloria Ten Figas, Revital Ben-Daniel
Abstract: Provided are ibrutinib polymorphs, e.g., crystalline ibrutinib Forms III, IV, V, VI, VII, VIII and Form IX and processes for producing these crystalline forms, stable amorphous ibrutinib and processes for preparing stable amorphous ibrutinib, pharmaceutical compositions comprising these forms and methods of using these crystalline and amorphous forms.
Type:
Application
Filed:
December 22, 2017
Publication date:
September 6, 2018
Applicant:
WAVELENGTH ENTERPRISES LTD.
Inventors:
Itai ADIN, Sonia KRIVONOS, Yevgeny ROZENBLAT, Alex WEISMAN, Ana FERNANDEZ CASARES, Gloria TEN FIGAS, Revital BEN-DANIEL