Abstract: A bottle cap for use with moulded plastics bottles which have an integral flanged seal over the aperture of a threaded neck, a frangible membrane joining the seal to the neck, the cap having a complementary screw-thread to that of the neck and at least two inwardly projecting resilient members located above the screw-thread such that, when the cap is screwed onto the bottle, the members pass around the seal with resilient deformation and, on unscrewing of the cap, engage the flanged seal in a lifting action, is characterized in that at least one, preferably 2, and ideally 6, of the inwardly projecting members comprises an upwardly directed blade, adapted to engage an underface of the seal so as to cut the seal, allowing its easier removal, a wall being preferably provided on the blade to reinforce the blade by acting against a side of the seal.

Abstract: The present invention provides plastics ampoules made by the blow-fill-seal method which substantially overcome the problems of vacuum formation and touch contamination, during use, by providing one or more grooves in the neck of the ampoule to allow replacement of displaced liquid with air and/or a head sealed to the mouth of the opening by a frangible membrane and tapering up towards a grip away from the opening, and optionally a funnel leading to the neck, this funnel also assisting docking of the head of a syringe.