Abstract: A dialysis service box for centralized control and plumbing arrangement of a dialysis machine is disclosed. The dialysis service box includes a plumbing arrangement having a supply inlet for supplying a fluid to the dialysis machine, a backflow preventer for preventing retrograde flow through the plumbing arrangement, a trap primer for maintaining a trap seal designed to prevent waste gases from flowing into the dialysis service box and a waste connection for allowing waste from the dialysis machine to exit. The dialysis service box can be universally installed to operate, control and adjust any dialysis machine that requires supply connection, waste connection, backflow preventer and trap primer, or any combination of the foregoing.